CFU-GM
{{Infobox cell
| Name = CFU-GM
| Latin =
| Image = Drzewko rozwojowe komórek macierzystych krwi.JPG
| Caption = Lineage. Captions in Polish, but "GMP" visible near bottom center.
| Image2 =
| Caption2 =
| Precursor =
| System =
| Location = Bone marrow
| Function = colony forming unit
| GivesRiseTo = Monoblasts and myeloblasts
}}
CFU-GM (Colony Forming Unit–Granulocyte–Macrophage{{efn|The "GM" can also stand for "Granulocyte-Monocyte".{{cite web|url=http://www.clt.astate.edu/wwilliam/hem_i_wbc_morphology_and_physiology.htm |title=Hem I WBC Morphology and Physiology |access-date=2008-12-30 |url-status=dead |archive-url=https://web.archive.org/web/20081225064942/http://www.clt.astate.edu/wwilliam/hem_i_wbc_morphology_and_physiology.htm |archive-date=December 25, 2008 }}}}), also known as granulocyte–macrophage progenitor (GMP), is a colony forming unit. It is derived from CFU-GEMM. It is the precursor for monoblasts and myeloblasts. Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).
Granulocytes
There is some controversy over which granulocytes derive from CFU-GM.
- There is little disagreement that neutrophils come from CFU-GM.
- Some sources state that basophils also derive from CFU-GM, but that eosinophils come from "CFU-Eos".{{cite book |author=Ganong, William F. |author2=McPhee, Stephen J. |author3=Lingappa, Vishwanath R. |title=Pathophysiology of Disease: An Introduction to Clinical Medicine (Lange) |publisher=McGraw-Hill Medical |year=2005 |pages=107 |isbn=0-07-144159-X }}
- Other sources state that basophils do not derive from CFU-GM, but from a distinct CFU, titled "CFU-Baso".{{cite book |author=Rudolph, Colin David |title=Rudolph's pediatrics |publisher=McGraw-Hill, Medical Pub. Division |location=New York |year=2003 |pages=1563 |isbn=0-8385-8285-0 }}
See also
Notes
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References
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External links
- {{MeshName|CFU-GM}}
{{Myeloid blood cells and plasma}}
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