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CHL1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

{{about|the cell adhesion molecule|NRT 1.1, a dual-affinity plant nitrate transporter formally known as CHL1{{cite book | last1=Pandey | first1=G. | last2=Kanwar | first2=P. | last3=Pandey | first3 =A. | title=Global Comparative Analysis of CBL-CIPK Gene Families in Plants | publisher=Springer International Publishing | year=2014 | isbn=978-3-319-09078-8 | url=https://books.google.com/books?id=P71ABAAAQBAJ&pg=PA52 | page=52}}|major facilitator superfamily}}

Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene.{{cite journal | vauthors = Wei MH, Karavanova I, Ivanov SV, Popescu NC, Keck CL, Pack S, Eisen JA, Lerman MI | title = In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules | journal = Hum. Genet. | volume = 103 | issue = 3 | pages = 355–64 |date=September 1998 | pmid = 9799093 | doi = 10.1007/s004390050829| s2cid = 3177127 }}

CHL1 is a cell adhesion molecule closely related to the L1. In melanocytic cells CHL1 gene expression may be regulated by MITF,{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x | s2cid = 24698373 |display-authors=etal| doi-access = free }} and can act as a helicase protein during the interphase stage of mitosis.

The protein, however, has dynamic localisation, meaning that it has not only multiple roles in the cell, but also various locations.

References

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Further reading

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  • {{cite journal |vauthors=Chen QY, Chen Q, Feng GY |title=Case-control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population. |journal=Schizophr. Res. |volume=73 |issue= 2–3 |pages= 269–74 |year= 2005 |pmid= 15653271 |doi= 10.1016/j.schres.2004.06.001 |s2cid=40310550 |display-authors=etal}}
  • {{cite journal |vauthors=Manderson EN, Birch AH, Shen Z |title=Molecular genetic analysis of a cell adhesion molecule with homology to L1CAM, contactin 6, and contactin 4 candidate chromosome 3p26pter tumor suppressor genes in ovarian cancer. |journal=Int. J. Gynecol. Cancer |volume=19 |issue= 4 |pages= 513–25 |year= 2009 |pmid= 19509545 |doi= 10.1111/IGC.0b013e3181a3cd38 |s2cid=27315616 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Rose JE, Behm FM, Drgon T |title=Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. |journal=Mol. Med. |volume=16 |issue= 7–8 |pages= 247–53 |year= 2010|pmid= 20379614 |pmc=2896464 |doi= 10.2119/molmed.2009.00159 |display-authors=etal}}
  • {{cite journal |vauthors=Tam GW, van de Lagemaat LN, Redon R |s2cid=31716113 |title=Confirmed rare copy number variants implicate novel genes in schizophrenia. |journal=Biochem. Soc. Trans. |volume=38 |issue= 2 |pages= 445–51 |year= 2010 |pmid= 20298200 |doi= 10.1042/BST0380445 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |pmc=528928 |doi= 10.1101/gr.2596504 |display-authors=etal}}
  • {{cite journal |vauthors=Gast D, Riedle S, Riedle S |title=L1 augments cell migration and tumor growth but not beta3 integrin expression in ovarian carcinomas. |journal=Int. J. Cancer |volume=115 |issue= 4 |pages= 658–65 |year= 2005 |pmid= 15704102 |doi= 10.1002/ijc.20869 |s2cid=44309818 |display-authors=etal}}
  • {{cite journal |vauthors=Lim SD, Stallcup W, Lefkove B |title=Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma: are angiomyolipomas neoplasms of stem cells? |journal=Mol. Med. |volume=13 |issue= 3–4 |pages= 160–5 |year= 2007|pmid= 17592550 |pmc=1892760 |doi= 10.2119/2006-00070.Lim |display-authors=etal}}
  • {{cite journal |vauthors=Palmieri RT, Wilson MA, Iversen ES |title=Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=17 |issue= 12 |pages= 3567–72 |year= 2008 |pmid= 19064572 |pmc=2664299 |doi= 10.1158/1055-9965.EPI-08-0548 |display-authors=etal}}
  • {{cite journal |vauthors=Sakurai K, Migita O, Toru M, Arinami T |title=An association between a missense polymorphism in the close homologue of L1 (CHL1, CALL) gene and schizophrenia. |journal=Mol. Psychiatry |volume=7 |issue= 4 |pages= 412–5 |year= 2002 |pmid= 11986985 |doi= 10.1038/sj.mp.4000973 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2005|pmid= 16335952 |pmc=1850943 |doi= 10.1021/pr0502065 |display-authors=etal}}
  • {{cite journal |vauthors=Whittard JD, Sakurai T, Cassella MR |title=MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin binding site regulates neuronal growth. |journal=Mol. Biol. Cell |volume=17 |issue= 6 |pages= 2696–706 |year= 2006 |pmid= 16597699 |pmc=1474804 |doi= 10.1091/mbc.E06-01-0090 |display-authors=etal}}
  • {{cite journal |vauthors=Angeloni D, Lindor NM, Pack S |title=CALL gene is haploinsufficient in a 3p- syndrome patient. |journal=Am. J. Med. Genet. |volume=86 |issue= 5 |pages= 482–5 |year= 1999 |pmid= 10508992 |doi=10.1002/(SICI)1096-8628(19991029)86:5<482::AID-AJMG15>3.0.CO;2-L |hdl=11382/301711 |display-authors=etal|url=https://www.iris.sssup.it/bitstream/11382/301711/1/1999%20Angeloni%20et%20al%20AJMG.pdf |hdl-access=free }}

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External links

  • {{MeshName|CHL1+protein,+human}}
  • {{UCSC gene info|CHL1}}

{{Cell adhesion molecules}}

{{membrane-protein-stub}}