CHRNA2

Knockout of this gene in mice potentiates nicotine-modulated behaviors.{{cite journal | vauthors = Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J | title = Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors | journal = J. Neurosci. | volume = 33 | issue = 18 | pages = 7728–41 |date=May 2013 | pmid = 23637165 | doi = 10.1523/JNEUROSCI.4731-12.2013 | pmc=3831006}}

Using two different genetically modified mutant mouse lines (Chrna2L9'S/L9'S and Chrna2KO), findings highlight that α2* nAChRs influence hippocampus-dependent learning and memory and CA1 synaptic plasticity in adolescent mice. {{cite journal | vauthors = Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J | title = α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice. | journal = Learn Mem | volume = 24 | issue = 6 | pages = 231–244 |date=May 2017 | pmid = 28507032 | doi = 10.1101/lm.045369.117 | pmc=5435881}}

• Nicotinic acetylcholine receptor

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• {{cite journal | vauthors=Wood S, Schertzer M, Yaremko ML |title=Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA |journal=Somat. Cell Mol. Genet. |volume=21 |issue= 2 |pages= 147–50 |year= 1995 |pmid= 7570187 |doi=10.1007/BF02255790 |s2cid=28611125 }}
• {{cite journal | vauthors=García-Colunga J, Miledi R |title=Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 7 |pages= 2919–23 |year= 1995 |pmid= 7708749 |doi=10.1073/pnas.92.7.2919 | pmc=42330 |bibcode=1995PNAS...92.2919G |doi-access=free }}
• {{cite journal | vauthors=Elliott KJ, Ellis SB, Berckhan KJ |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217–28 |year= 1997 |pmid= 8906617 |doi=10.1007/BF02736842 |s2cid=45737923 |display-authors=etal}}
• {{cite journal | vauthors=Chavez-Noriega LE, Crona JH, Washburn MS |title=Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes |journal=J. Pharmacol. Exp. Ther. |volume=280 |issue= 1 |pages= 346–56 |year= 1997 |pmid= 8996215 |display-authors=etal}}
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• {{cite journal | vauthors=Sato KZ, Fujii T, Watanabe Y |title=Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines |journal=Neurosci. Lett. |volume=266 |issue= 1 |pages= 17–20 |year= 1999 |pmid= 10336173 |doi=10.1016/S0304-3940(99)00259-1 |s2cid=43548155 |display-authors=etal}}
• {{cite journal | vauthors=Bertrand D, Picard F, Le Hellard S |title=How mutations in the nAChRs can cause ADNFLE epilepsy |journal=Epilepsia |volume=43 |pages= 112–22 |year= 2002 |issue=Suppl 5 |pmid= 12121305 |doi=10.1046/j.1528-1157.43.s.5.16.x |s2cid=32858402 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Jin P, Fu GK, Wilson AD |title=PCR isolation and cloning of novel splice variant mRNAs from known drug target genes |journal=Genomics |volume=83 |issue= 4 |pages= 566–71 |year= 2004 |pmid= 15028279 |doi= 10.1016/j.ygeno.2003.09.023 |display-authors=etal}}
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• {{cite journal | vauthors=Nusbaum C, Mikkelsen TS, Zody MC |title=DNA sequence and analysis of human chromosome 8 |journal=Nature |volume=439 |issue= 7074 |pages= 331–5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 |bibcode=2006Natur.439..331N |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Aridon P, Marini C, Di Resta C |title=Increased Sensitivity of the Neuronal Nicotinic Receptor α2 Subunit Causes Familial Epilepsy with Nocturnal Wandering and Ictal Fear |journal=Am. J. Hum. Genet. |volume=79 |issue= 2 |pages= 342–50 |year= 2006 |pmid= 16826524 |doi= 10.1086/506459 | pmc=1559502 |display-authors=etal}}

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• {{MeshName|CHRNA2+protein,+human}}
• {{UCSC gene info|CHRNA2}}

{{NLM content}}

{{Ligand-gated ion channels}}

Category:Nicotinic acetylcholine receptors

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