CHST6
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Carbohydrate sulfotransferase 6 is an enzyme that in humans is encoded by the CHST6 gene.{{cite journal | vauthors = Vance JM, Jonasson F, Lennon F, Sarrica J, Damji KF, Stauffer J, Pericak-Vance MA, Klintworth GK | title = Linkage of a gene for macular corneal dystrophy to chromosome 16 | journal = Am J Hum Genet | volume = 58 | issue = 4 | pages = 757–62 |date=Jul 1996 | pmid = 8644739 | pmc = 1914688 }}{{cite journal | vauthors = Akama TO, Nishida K, Nakayama J, Watanabe H, Ozaki K, Nakamura T, Dota A, Kawasaki S, Inoue Y, Maeda N, Yamamoto S, Fujiwara T, Thonar EJ, Shimomura Y, Kinoshita S, Tanigami A, Fukuda MN | title = Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene | journal = Nat Genet | volume = 26 | issue = 2 | pages = 237–41 |date=Nov 2000 | pmid = 11017086 | doi = 10.1038/79987 | s2cid = 25547752 }}{{cite web | title = Entrez Gene: CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4166}}
It codes for an enzyme necessary for the production of keratan sulfate. Mutations in the gene lead to macular corneal dystrophy.
References
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External links
- {{UCSC gene info|CHST6}}
Further reading
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- {{cite journal | vauthors=Bernstein HB, Compans RW |title=Sulfation of the human immunodeficiency virus envelope glycoprotein. |journal=J. Virol. |volume=66 |issue= 12 |pages= 6953–9 |year= 1992 |pmid= 1433500 |doi= 10.1128/JVI.66.12.6953-6959.1992| pmc=240329 }}
- {{cite journal | vauthors=Shilatifard A, Merkle RK, Helland DE |title=Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine. |journal=J. Virol. |volume=67 |issue= 2 |pages= 943–52 |year= 1993 |pmid= 8419650 |doi= 10.1128/JVI.67.2.943-952.1993| pmc=237448 |display-authors=etal}}
- {{cite journal | vauthors=Uchimura K, Fasakhany F, Kadomatsu K |title=Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 2 |pages= 291–6 |year= 2000 |pmid= 10913333 |doi= 10.1006/bbrc.2000.3141 |display-authors=etal}}
- {{cite journal | vauthors=Spiro MJ, Spiro RG |title=Sulfation of the N-linked oligosaccharides of influenza virus hemagglutinin: temporal relationships and localization of sulfotransferases. |journal=Glycobiology |volume=10 |issue= 11 |pages= 1235–42 |year= 2001 |pmid= 11087716 |doi=10.1093/glycob/10.11.1235 |doi-access=free }}
- {{cite journal | vauthors=Liu NP, Dew-Knight S, Rayner M |title=Mutations in corneal carbohydrate sulfotransferase 6 gene (CHST6) cause macular corneal dystrophy in Iceland. |journal=Mol. Vis. |volume=6 |pages= 261–4 |year= 2001 |pmid= 11139648 |display-authors=etal}}
- {{cite journal | vauthors=Hemmerich S, Lee JK, Bhakta S |title=Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family. |journal=Glycobiology |volume=11 |issue= 1 |pages= 75–87 |year= 2001 |pmid= 11181564 |doi=10.1093/glycob/11.1.75 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Akama TO, Nakayama J, Nishida K |title=Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate. |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16271–8 |year= 2001 |pmid= 11278593 |doi= 10.1074/jbc.M009995200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Bartes A, Bhakta S, Hemmerich S |title=Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta). |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 4 |pages= 928–33 |year= 2001 |pmid= 11352640 |doi= 10.1006/bbrc.2001.4668 }}
- {{cite journal | vauthors=El-Ashry MF, Abd El-Aziz MM, Wilkins S |title=Identification of novel mutations in the carbohydrate sulfotransferase gene (CHST6) causing macular corneal dystrophy. |journal=Invest. Ophthalmol. Vis. Sci. |volume=43 |issue= 2 |pages= 377–82 |year= 2002 |pmid= 11818380 |display-authors=etal}}
- {{cite journal | vauthors=Akama TO, Misra AK, Hindsgaul O, Fukuda MN |title=Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42505–13 |year= 2003 |pmid= 12218059 |doi= 10.1074/jbc.M207412200 |doi-access= free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Niel F, Ellies P, Dighiero P |title=Truncating mutations in the carbohydrate sulfotransferase 6 gene (CHST6) result in macular corneal dystrophy. |journal=Invest. Ophthalmol. Vis. Sci. |volume=44 |issue= 7 |pages= 2949–53 |year= 2003 |pmid= 12824236 |doi=10.1167/iovs.02-0740 |display-authors=etal|doi-access= }}
- {{cite journal | vauthors=Iida-Hasegawa N, Furuhata A, Hayatsu H |title=Mutations in the CHST6 gene in patients with macular corneal dystrophy: immunohistochemical evidence of heterogeneity. |journal=Invest. Ophthalmol. Vis. Sci. |volume=44 |issue= 8 |pages= 3272–7 |year= 2003 |pmid= 12882769 |doi=10.1167/iovs.02-0910 |display-authors=etal|doi-access= }}
- {{cite journal | vauthors=Ha NT, Chau HM, Cung le X |title=Mutation analysis of the carbohydrate sulfotransferase gene in Vietnamese with macular corneal dystrophy. |journal=Invest. Ophthalmol. Vis. Sci. |volume=44 |issue= 8 |pages= 3310–6 |year= 2003 |pmid= 12882775 |doi=10.1167/iovs.03-0031 |display-authors=etal|doi-access= }}
- {{cite journal | vauthors=Ha NT, Chau HM, Cung le X |title=Identification of novel mutations of the CHST6 gene in Vietnamese families affected with macular corneal dystrophy in two generations. |journal=Cornea |volume=22 |issue= 6 |pages= 508–11 |year= 2003 |pmid= 12883341 |doi=10.1097/00003226-200308000-00004 |s2cid=25039164 |display-authors=etal}}
- {{cite journal | vauthors=Warren JF, Aldave AJ, Srinivasan M |title=Novel mutations in the CHST6 gene associated with macular corneal dystrophy in southern India. |journal=Arch. Ophthalmol. |volume=121 |issue= 11 |pages= 1608–12 |year= 2003 |pmid= 14609920 |doi= 10.1001/archopht.121.11.1608 |display-authors=etal|doi-access= }}
- {{cite journal | vauthors=Sultana A, Sridhar MS, Jagannathan A |title=Novel mutations of the carbohydrate sulfotransferase-6 (CHST6) gene causing macular corneal dystrophy in India. |journal=Mol. Vis. |volume=9 |pages= 730–4 |year= 2004 |pmid= 14735064 |display-authors=etal}}
- {{cite journal | vauthors=Abbruzzese C, Kuhn U, Molina F |title=Novel mutations in the CHST6 gene causing macular corneal dystrophy. |journal=Clin. Genet. |volume=65 |issue= 2 |pages= 120–5 |year= 2004 |pmid= 14984470 |doi=10.1111/j.0009-9163.2004.00191.x |s2cid=32667901 |display-authors=etal}}
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