CIBERSORT

CIBERSORT, also called CIBERSORTx, is a bioinformatics tool used to deconvolute cell type proportions and gene expression profiles from bulk RNA sequencing datasets.{{Cite journal |last=Newman |first=Aaron M. |last2=Liu |first2=Chih Long |last3=Green |first3=Michael R. |last4=Gentles |first4=Andrew J. |last5=Feng |first5=Weiguo |last6=Xu |first6=Yue |last7=Hoang |first7=Chuong D. |last8=Diehn |first8=Maximilian |last9=Alizadeh |first9=Ash A. |date=2015 |title=Robust enumeration of cell subsets from tissue expression profiles |url=https://www.nature.com/articles/nmeth.3337 |journal=Nature Methods |language=en |volume=12 |issue=5 |pages=453–457 |doi=10.1038/nmeth.3337 |issn=1548-7105|pmc=4739640 }}{{Cite journal |last=Newman |first=Aaron M. |last2=Steen |first2=Chloé B. |last3=Liu |first3=Chih Long |last4=Gentles |first4=Andrew J. |last5=Chaudhuri |first5=Aadel A. |last6=Scherer |first6=Florian |last7=Khodadoust |first7=Michael S. |last8=Esfahani |first8=Mohammad S. |last9=Luca |first9=Bogdan A. |last10=Steiner |first10=David |last11=Diehn |first11=Maximilian |last12=Alizadeh |first12=Ash A. |date=2019 |title=Determining cell type abundance and expression from bulk tissues with digital cytometry |url=https://www.nature.com/articles/s41587-019-0114-2 |journal=Nature Biotechnology |language=en |volume=37 |issue=7 |pages=773–782 |doi=10.1038/s41587-019-0114-2 |issn=1546-1696|pmc=6610714 }}{{Citation |last=Chen |first=Binbin |title=Profiling Tumor Infiltrating Immune Cells with CIBERSORT |date=2018 |url=http://link.springer.com/10.1007/978-1-4939-7493-1_12 |work=Cancer Systems Biology |volume=1711 |pages=243–259 |editor-last=von Stechow |editor-first=Louise |place=New York, NY |publisher=Springer New York |language=en |doi=10.1007/978-1-4939-7493-1_12 |isbn=978-1-4939-7492-4 |pmc=5895181 |pmid=29344893 |access-date=2023-02-01 |last2=Khodadoust |first2=Michael S. |last3=Liu |first3=Chih Long |last4=Newman |first4=Aaron M. |last5=Alizadeh |first5=Ash A.}}{{Citation |last=Steen |first=Chloé B. |title=Profiling Cell Type Abundance and Expression in Bulk Tissues with CIBERSORTx |date=2020 |url=https://doi.org/10.1007/978-1-0716-0301-7_7 |work=Stem Cell Transcriptional Networks: Methods and Protocols |pages=135–157 |editor-last=Kidder |editor-first=Benjamin L. |place=New York, NY |publisher=Springer US |language=en |doi=10.1007/978-1-0716-0301-7_7 |isbn=978-1-0716-0301-7 |pmc=7695353 |pmid=31960376 |access-date=2023-02-08 |last2=Liu |first2=Chih Long |last3=Alizadeh |first3=Ash A. |last4=Newman |first4=Aaron M.}} It is among the fastest growing software tools in the life sciences.{{Cite journal |last=Hutson |first=Matthew |date=2023-01-12 |title=Hunting for the best bioscience software tool? Check this database |url=https://www.nature.com/articles/d41586-023-00053-w |journal=Nature |language=en |doi=10.1038/d41586-023-00053-w}}

References

Category:Biotechnology