CIDEB
{{Short description|Protein-coding gene in humans}}
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Cell death-inducing DFFA-like effector b, also known as CIDEB, is a human gene.{{cite web | title = Entrez Gene: CIDEB cell death-inducing DFFA-like effector b| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27141}}{{cite journal | last1 = Ye | first1 = Jing | last2 = Zhong Li | first2 = John | last3 = Liu | first3 = Yang | last4 = Li | first4 = Xuanhe | last5 = Yang | first5 = Tianshu | last6 = Ma | first6 = Xiaodong | last7 = Li | first7 = Qing | last8 = Yao | first8 = Zemin | last9 = Li | first9 = Peng | year = 2009 | title = Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B. | journal = Cell Metabolism | volume = 9 | issue = 2| pages = 177–190 | doi=10.1016/j.cmet.2008.12.013 | pmid=19187774| doi-access = free }}{{cite journal | last1 = Li | first1 = JZ | last2 = Lei | first2 = Y | last3 = Wang | first3 = Y | last4 = Zhang | first4 = Y | last5 = Ye | first5 = J | last6 = Xia | first6 = X | last7 = Pan | first7 = X | last8 = Li | first8 = P | date = May 2010 | title = Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb | journal = Biochim Biophys Acta | volume = 1801 | issue = 5| pages = 577–86 | doi=10.1016/j.bbalip.2010.01.012 | pmid=20123130}}
In humans, individuals carrying rare loss of function mutations in the CIDEB gene are protected against different aetiologies of liver disease.{{Cite journal |last1=Verweij |first1=Niek |last2=Haas |first2=Mary E. |last3=Nielsen |first3=Jonas B. |last4=Sosina |first4=Olukayode A. |last5=Kim |first5=Minhee |last6=Akbari |first6=Parsa |last7=De |first7=Tanima |last8=Hindy |first8=George |last9=Bovijn |first9=Jonas |last10=Persaud |first10=Trikaldarshi |last11=Miloscio |first11=Lawrence |last12=Germino |first12=Mary |last13=Panagis |first13=Lampros |last14=Watanabe |first14=Kyoko |last15=Mbatchou |first15=Joelle |date=2022-07-28 |title=Germline Mutations in CIDEB and Protection against Liver Disease |journal=New England Journal of Medicine |volume=387 |issue=4 |pages=332–344 |doi=10.1056/NEJMoa2117872 |issn=0028-4793 |pmid=35939579|s2cid=251143047 |doi-access=free }} CIDEB knockout mice have been generated by homolog recombination technique. The CIDE null mice show decreased lipogenesis. The CIDEB knockout mice are resistant to high fat diet induced obesity and liver steatosis. In addition, the CIDEB null mice also have improved insulin sensitivity and enhanced hepatic fatty acid oxidation and whole body metabolism.{{cite journal | last1 = Zhong Li | first1 = John | last2 = Ye | first2 = Jing | last3 = Xue | first3 = Bofu | last4 = Qi | first4 = Jingzong | last5 = Zhang | first5 = Jing | last6 = Zhou | first6 = Zhihong | last7 = Li | first7 = Qing | last8 = Wen | first8 = Zilong | last9 = Li | first9 = Peng | year = 2007 | title = Cideb regulates diet-induced obesity, liver steatosis and insulin sensitivity by controlling lipogeneis and fatty acid oxidation | url = http://diabetes.diabetesjournals.org/cgi/content/short/56/10/2523 | journal = Diabetes | volume = 56 | issue = 10| pages = 2523–2532 | doi=10.2337/db07-0040 | pmid=17646209| doi-access = free }} CIDEB plays a key role in determining lipid droplet size: overexpression of CIDEB in vitro results in fat accumulation by inducing larger lipid droplets, while CIDEB knock-out experiments results in accumulation of smaller lipid droplets.{{Cite journal |last1=Xu |first1=Wenyi |last2=Wu |first2=Lizhen |last3=Yu |first3=Miao |last4=Chen |first4=Feng-Jung |last5=Arshad |first5=Muhammad |last6=Xia |first6=Xiayu |last7=Ren |first7=Hao |last8=Yu |first8=Jinhai |last9=Xu |first9=Li |last10=Xu |first10=Dijin |last11=Li |first11=John Zhong |last12=Li |first12=Peng |last13=Zhou |first13=Linkang |date=2016-02-26 |title=Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes |journal=The Journal of Biological Chemistry |volume=291 |issue=9 |pages=4282–4293 |doi=10.1074/jbc.M115.701094 |issn=1083-351X |pmc=4813457 |pmid=26733203|doi-access=free }}
References
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Further reading
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- {{cite journal | vauthors=Inohara N, Koseki T, Chen S |title=CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. |journal=EMBO J. |volume=17 |issue= 9 |pages= 2526–33 |year= 1998 |pmid= 9564035 |doi= 10.1093/emboj/17.9.2526 | pmc=1170594 |display-authors=etal}}
- {{cite journal | vauthors=Lugovskoy AA, Zhou P, Chou JJ |title=Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. |journal=Cell |volume=99 |issue= 7 |pages= 747–55 |year= 2000 |pmid= 10619428 |doi=10.1016/S0092-8674(00)81672-4 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Chen Z, Guo K, Toh SY |title=Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22619–22 |year= 2000 |pmid= 10837461 |doi= 10.1074/jbc.C000207200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Liang L, Zhao M, Xu Z |title=Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family. |journal=Biochem. J. |volume=370 |issue= Pt 1 |pages= 195–203 |year= 2003 |pmid= 12429024 |doi= 10.1042/BJ20020656 | pmc=1223158 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Erdtmann L, Franck N, Lerat H |title=The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18256–64 |year= 2003 |pmid= 12595532 |doi= 10.1074/jbc.M209732200 |display-authors=etal|doi-access=free |url=https://hal.archives-ouvertes.fr/hal-02239686/file/PIIS0021925819549250.pdf }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Da L, Li D, Yokoyama KK |title=Dual promoters control the cell-specific expression of the human cell death-inducing DFF45-like effector B gene. |journal=Biochem. J. |volume=393 |issue= Pt 3 |pages= 779–88 |year= 2006 |pmid= 16248853 |doi= 10.1042/BJ20051027 | pmc=1360731 |display-authors=etal}}
- {{cite journal | vauthors=Li JZ, Lei Y, Wang Y, Zhang Y, Ye J, Xia X, Pan X, Li P |title=Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb |journal=Biochim Biophys Acta |volume=1801 |issue= Pt 5 |pages= 577–586 |year= 2010 |pmid= 20123130 |doi= 10.1016/j.bbalip.2010.01.012|display-authors=etal}}
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