CIZ1

Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.{{cite journal | vauthors = Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A | title = Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1 | journal = Biochemical and Biophysical Research Communications | volume = 264 | issue = 2 | pages = 457–64 | date = October 1999 | pmid = 10529385 | doi = 10.1006/bbrc.1999.1516 }}{{cite web | title = Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25792}}

Function

The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.

Clinical significance

An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.{{cite journal | vauthors = Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, Ainscough JF, Coverley D | display-authors = 6 | title = Variant Ciz1 is a circulating biomarker for early-stage lung cancer | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 45 | pages = E3128-35 | date = November 2012 | pmid = 23074256 | pmc = 3494940 | doi = 10.1073/pnas.1210107109 | doi-access = free }}

''Ciz1'' mutant mice

Aged (18-mo-old) Ciz1^-/- mice have increased neuronal DNA double-strand breaks that likely contributed to their loss of neurons and cognitive decline with age.{{cite journal | vauthors = Khan MM, Xiao J, Patel D, LeDoux MS | title = DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice | journal = Neurobiology of Aging | volume = 62 | issue = | pages = 180–190 | date = February 2018 | pmid = 29154038 | pmc = 5877805 | doi = 10.1016/j.neurobiolaging.2017.10.014 }} Embryonic fibroblasts from Ciz1^-/- mice show abnormal sensitivity to γ-irradiation with persistent DNA breaks, aberrant cell cycle progression and increased apoptosis.

Interactions

CIZ1 has been shown to interact with P21.

References

External links

{{UCSC gene info|CIZ1}}

{{cite journal | vauthors = Lukasik A, Uniewicz KA, Kulis M, Kozlowski P | title = Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog | journal = The FEBS Journal | volume = 275 | issue = 2 | pages = 332–40 | date = January 2008 | pmid = 18081865 | doi = 10.1111/j.1742-4658.2007.06203.x | s2cid = 35928583 | doi-access = free }}
{{cite journal | vauthors = Rahman F, Ainscough JF, Copeland N, Coverley D | title = Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1 | journal = Human Mutation | volume = 28 | issue = 10 | pages = 993–1004 | date = October 2007 | pmid = 17508423 | doi = 10.1002/humu.20550 | s2cid = 34590449 | doi-access = free }}
{{cite journal | vauthors = den Hollander P, Rayala SK, Coverley D, Kumar R | title = Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action | journal = Cancer Research | volume = 66 | issue = 22 | pages = 11021–9 | date = November 2006 | pmid = 17108141 | doi = 10.1158/0008-5472.CAN-06-2336 | doi-access = free }}
{{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
{{cite journal | vauthors = Coverley D, Marr J, Ainscough J | title = Ciz1 promotes mammalian DNA replication | journal = Journal of Cell Science | volume = 118 | issue = Pt 1 | pages = 101–12 | date = January 2005 | pmid = 15585571 | doi = 10.1242/jcs.01599 | doi-access = free }}
{{cite journal | vauthors = Warder DE, Keherly MJ | title = Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC | journal = Journal of Biomedical Science | volume = 10 | issue = 4 | pages = 406–17 | year = 2004 | pmid = 12824700 | doi = 10.1159/000071160 | s2cid = 202648843 }}
{{cite journal | vauthors = Gilley J, Fried M | title = Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes | journal = Human Molecular Genetics | volume = 8 | issue = 7 | pages = 1313–20 | date = July 1999 | pmid = 10369878 | doi = 10.1093/hmg/8.7.1313 | doi-access = free }}