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CLCA1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.{{cite journal | vauthors = Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU | title = Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl− channel proteins | journal = Genomics | volume = 54 | issue = 2 | pages = 200–14 |date=Jan 1999 | pmid = 9828122 | doi = 10.1006/geno.1998.5562 | doi-access = free }}

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.{{cite web | title = Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1179}} Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.{{cite journal | vauthors=Pawłowski K, Lepistö M, Meinander N |title=Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels |journal=Proteins |volume=63 |issue= 3 |pages= 424–39 |year= 2006 |pmid= 16470849|doi= 10.1002/prot.20887|s2cid=40041491 |display-authors=etal}}

See also

References

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Further reading

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  • {{cite journal | vauthors=Hume JR, Duan D, Collier ML |title=Anion transport in heart |journal=Physiol. Rev. |volume=80 |issue= 1 |pages= 31–81 |year= 2000 |doi=10.1152/physrev.2000.80.1.31 |pmid= 10617765 |s2cid=15954128 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Pauli BU, Abdel-Ghany M, Cheng HC |title=Molecular characteristics and functional diversity of CLCA family members |journal=Clin. Exp. Pharmacol. Physiol. |volume=27 |issue= 11 |pages= 901–5 |year= 2001 |pmid= 11071307 |doi=10.1046/j.1440-1681.2000.03358.x |s2cid=28762005 |display-authors=etal}}
  • {{cite journal | vauthors=Agnel M, Vermat T, Culouscou JM |title=Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea |journal=FEBS Lett. |volume=455 |issue= 3 |pages= 295–301 |year= 1999 |pmid= 10437792 |doi=10.1016/S0014-5793(99)00891-1 |s2cid=82094058 |doi-access=free }}
  • {{cite journal | vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 |bibcode=2000PNAS...97.3491D |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Liu QH, Williams DA, McManus C |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832–7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697 | pmc=18318 |bibcode=2000PNAS...97.4832L |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Toda M, Tulic MK, Levitt RC, Hamid Q |title=A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma |journal=J. Allergy Clin. Immunol. |volume=109 |issue= 2 |pages= 246–50 |year= 2002 |pmid= 11842292 |doi=10.1067/mai.2002.121555 |doi-access=free }}
  • {{cite journal | vauthors=Greenwood IA, Miller LJ, Ohya S, Horowitz B |title=The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1 |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22119–22 |year= 2002 |pmid= 11994272 |doi= 10.1074/jbc.C200215200 |doi-access= free }}
  • {{cite journal | vauthors=Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU |title=Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34391–400 |year= 2002 |pmid= 12110680 |doi= 10.1074/jbc.M205307200 |doi-access= free }}
  • {{cite journal | vauthors=Loewen ME, Bekar LK, Gabriel SE |title=pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 4 |pages= 531–6 |year= 2002 |pmid= 12408984 |doi=10.1016/S0006-291X(02)02498-1 |display-authors=etal}}
  • {{cite book | vauthors=Zhou Y, Shapiro M, Dong Q |title=Mucus Hypersecretion in Respiratory Disease |chapter=A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction |series=Novartis Foundation Symposia |volume=248 |pages= 150–65; discussion 165–70, 277–82 |year= 2003 |pmid= 12568493 |doi=10.1002/0470860790.ch10 |isbn=9780470844786 |display-authors=etal}}
  • {{cite journal | vauthors=Abdel-Ghany M, Cheng HC, Elble RC |title=The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49406–16 |year= 2004 |pmid= 14512419 |doi= 10.1074/jbc.M309086200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Hegab AE, Sakamoto T, Uchida Y |title=CLCA1 gene polymorphisms in chronic obstructive pulmonary disease |journal=J. Med. Genet. |volume=41 |issue= 3 |pages= 27e–27 |year= 2004 |pmid= 14985398 |doi=10.1136/jmg.2003.012484 | pmc=1735703 |display-authors=etal}}
  • {{cite journal | vauthors=Kamada F, Suzuki Y, Shao C |title=Association of the hCLCA1 gene with childhood and adult asthma |journal=Genes Immun. |volume=5 |issue= 7 |pages= 540–7 |year= 2005 |pmid= 15318163 |doi= 10.1038/sj.gene.6364124 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ritzka M, Stanke F, Jansen S |title=The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis |journal=Hum. Genet. |volume=115 |issue= 6 |pages= 483–91 |year= 2005 |pmid= 15490240 |doi= 10.1007/s00439-004-1190-y |s2cid=12935280 |display-authors=etal}}
  • {{cite journal | vauthors=Gibson A, Lewis AP, Affleck K |title=hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels |journal=J. Biol. Chem. |volume=280 |issue= 29 |pages= 27205–12 |year= 2005 |pmid= 15919655 |doi= 10.1074/jbc.M504654200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Jeong SM, Park HK, Yoon IS |title=Cloning and expression of Ca2+-activated chloride channel from rat brain |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 2 |pages= 569–76 |year= 2005 |pmid= 16023076 |doi= 10.1016/j.bbrc.2005.06.122 |display-authors=etal}}

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External links

  • {{MeshName|CLCA1+protein,+human}}
  • {{UCSC gene info|CLCA1}}

{{NLM content}}

{{Ion channels|g4}}

Category:Chloride channels

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