CLDN1

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.{{cite web | title = Entrez Gene: CLDN1 claudin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9076}}

CLDN1 has been shown to interact with CLDN5{{cite journal | vauthors = Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG | title = Role of claudin interactions in airway tight junctional permeability | journal = Am. J. Physiol. Lung Cell Mol. Physiol. | volume = 285 | issue = 5 | pages = L1166-78 | date = Nov 2003 | pmid = 12909588 | doi = 10.1152/ajplung.00182.2003 }} and CLDN3.

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• {{UCSC gene info|CLDN1}}

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• {{cite journal | vauthors = Kniesel U, Wolburg H | title = Tight junctions of the blood-brain barrier | journal = Cell. Mol. Neurobiol. | volume = 20 | issue = 1 | pages = 57–76 | year = 2000 | pmid = 10690502 | doi = 10.1023/A:1006995910836 | s2cid = 26473781 | pmc = 11537529 }}
• {{cite journal | vauthors = Heiskala M, Peterson PA, Yang Y | title = The roles of claudin superfamily proteins in paracellular transport | journal = Traffic | volume = 2 | issue = 2 | pages = 93–8 | year = 2001 | pmid = 11247307 | doi = 10.1034/j.1600-0854.2001.020203.x | s2cid = 12132159 | doi-access = }}
• {{cite journal | vauthors = Tsukita S, Furuse M, Itoh M | title = Multifunctional strands in tight junctions | journal = Nat. Rev. Mol. Cell Biol. | volume = 2 | issue = 4 | pages = 285–93 | year = 2001 | pmid = 11283726 | doi = 10.1038/35067088 | s2cid = 36524601 }}
• {{cite journal | vauthors = Tsukita S, Furuse M | title = Claudin-based barrier in simple and stratified cellular sheets | journal = Curr. Opin. Cell Biol. | volume = 14 | issue = 5 | pages = 531–6 | year = 2002 | pmid = 12231346 | doi = 10.1016/S0955-0674(02)00362-9 }}
• {{cite journal | vauthors = González-Mariscal L, Betanzos A, Nava P, Jaramillo BE | title = Tight junction proteins | journal = Prog. Biophys. Mol. Biol. | volume = 81 | issue = 1 | pages = 1–44 | year = 2003 | pmid = 12475568 | doi = 10.1016/S0079-6107(02)00037-8 | doi-access = }}
• {{cite journal | vauthors = Swisshelm K, Macek R, Kubbies M | title = Role of claudins in tumorigenesis | journal = Adv. Drug Deliv. Rev. | volume = 57 | issue = 6 | pages = 919–28 | year = 2005 | pmid = 15820559 | doi = 10.1016/j.addr.2005.01.006 }}
• {{cite journal | vauthors = King JE, Eugenin EA, Buckner CM, Berman JW | title = HIV tat and neurotoxicity | journal = Microbes Infect. | volume = 8 | issue = 5 | pages = 1347–57 | year = 2006 | pmid = 16697675 | doi = 10.1016/j.micinf.2005.11.014 | doi-access = free }}
• {{cite journal | vauthors = Ye J | title = Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus | journal = PLOS Pathog. | volume = 3 | issue = 8 | pages = e108 | year = 2007 | pmid = 17784784 | pmc = 1959368 | doi = 10.1371/journal.ppat.0030108 | doi-access = free }}
• {{cite journal | vauthors = Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S | title = Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin | journal = J. Cell Biol. | volume = 141 | issue = 7 | pages = 1539–50 | year = 1998 | pmid = 9647647 | pmc = 2132999 | doi = 10.1083/jcb.141.7.1539 }}
• {{cite journal | vauthors = Swisshelm K, Machl A, Planitzer S, Robertson R, Kubbies M, Hosier S | title = SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily | journal = Gene | volume = 226 | issue = 2 | pages = 285–95 | year = 1999 | pmid = 9931503 | doi = 10.1016/S0378-1119(98)00553-8 }}
• {{cite journal | vauthors = Furuse M, Sasaki H, Tsukita S | title = Manner of interaction of heterogeneous claudin species within and between tight junction strands | journal = J. Cell Biol. | volume = 147 | issue = 4 | pages = 891–903 | year = 1999 | pmid = 10562289 | pmc = 2156154 | doi = 10.1083/jcb.147.4.891 }}
• {{cite journal | vauthors = Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S | title = Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1351–63 | year = 1999 | pmid = 10601346 | pmc = 2168087 | doi = 10.1083/jcb.147.6.1351 }}
• {{cite journal | vauthors = Krämer F, White K, Kubbies M, Swisshelm K, Weber BH | title = Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer | journal = Hum. Genet. | volume = 107 | issue = 3 | pages = 249–56 | year = 2000 | pmid = 11071387 | doi = 10.1007/s004390000375 | s2cid = 24898101 }}
• {{cite journal | vauthors = Miyamori H, Takino T, Kobayashi Y, Tokai H, Itoh Y, Seiki M, Sato H | title = Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases | journal = J. Biol. Chem. | volume = 276 | issue = 30 | pages = 28204–11 | year = 2001 | pmid = 11382769 | doi = 10.1074/jbc.M103083200 | doi-access = free | hdl = 2297/15688 | hdl-access = free }}
• {{cite journal | vauthors = Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S | title = Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule | journal = J. Biol. Chem. | volume = 277 | issue = 1 | pages = 455–61 | year = 2002 | pmid = 11689568 | doi = 10.1074/jbc.M109005200 | doi-access = free | hdl = 2433/148697 | hdl-access = free }}
• {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | volume = 15 | issue = 2 | pages = 339–359 | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 | pmc = 4777318 }}

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