CLDN17
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{infobox gene}}
Claudin-17 is a protein that in humans is encoded by the CLDN17 gene.{{cite journal | vauthors = Katoh M, Katoh M | title = CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family | journal = Int J Mol Med | volume = 11 | issue = 6 | pages = 683–9 |date=May 2003 | pmid = 12736707 | doi = 10.3892/ijmm.11.6.683}}{{cite web | title = Entrez Gene: CLDN17 claudin 17| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26285}} It belongs to the group of claudins; claudins are cell-cell junction proteins that keep that maintains cell- and tissue-barrier function.{{cite journal |last1=Adil |first1=MS |last2=Narayanan |first2=SP |last3=Somanath |first3=PR |title=Cell-cell junctions: structure and regulation in physiology and pathology. |journal=Tissue Barriers |year=2021 |volume=9 |issue=1 |page=1848212 |doi=10.1080/21688370.2020.1848212 |pmid=33300427 |pmc=7849786 |ref=5}} It forms anion-selective paracellular channels and is localized mainly in kidney proximal tubules.{{cite journal| vauthors = Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M | title = Claudin-17 forms tight junction channels with distinct anion selectivity | journal = Cell Mol Life Sci | volume = 69 | issue = 16 | pages = 2765–78 | year = 2012 |pmid=22402829 | doi= 10.1007/s00018-012-0949-x| s2cid = 18173604 | pmc = 11115135 }}{{cite journal |last1=Adil |first1=M |last2=Parvathagiri |first2=V |last3=Verma |first3=A |last4=Liu |first4=F |last5=Rudraraju |first5=M |last6=Narayanan |first6=SP |last7=Somanath |first7=PR |title=Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress |journal=Cells |year=2022 |volume=11 |issue=11 |page=1782 |doi=10.3390/cells11111782 |pmid=35681477 |pmc=9180152 |ref=4|doi-access=free }}
References
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External links
- {{UCSC gene info|CLDN17}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1–44 |year= 2003 |pmid= 12475568 |doi=10.1016/S0079-6107(02)00037-8 |doi-access= }}
- {{cite journal | vauthors=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531–6 |year= 2003 |pmid= 12231346 |doi=10.1016/S0955-0674(02)00362-9 }}
- {{cite journal | vauthors=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285–93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 |s2cid=36524601 }}
- {{cite journal | vauthors=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93–8 |year= 2001 |pmid= 11247307 |doi=10.1034/j.1600-0854.2001.020203.x |s2cid=12132159 |doi-access= }}
- {{cite journal | vauthors=Kniesel U, Wolburg H |title=Tight junctions of the blood–brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57–76 |year= 2000 |pmid= 10690502 |doi=10.1023/A:1006995910836 |s2cid=26473781 |pmc=11537529 }}
- {{cite journal | vauthors=Hu YH, Warnatz HJ, Vanhecke D |title=Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. |journal=BMC Genomics |volume=7|pages= 155 |year= 2006 |pmid= 16780588 |doi= 10.1186/1471-2164-7-155 | pmc=1526728 |display-authors=etal |doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Brandner JM, Kief S, Grund C |title=Organization and formation of the tight junction system in human epidermis and cultured keratinocytes. |journal=Eur. J. Cell Biol. |volume=81 |issue= 5 |pages= 253–63 |year= 2003 |pmid= 12067061 |doi=10.1078/0171-9335-00244 |display-authors=etal}}
- {{cite journal | vauthors=Hattori M, Fujiyama A, Taylor TD |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 |bibcode=2000Natur.405..311H |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | volume = 15 | issue = 2 | pages = 339–359 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 | pmc = 4777318 }}
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