CLDN9
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{cs1 config|name-list-style=vanc}}{{Infobox_gene}}
Claudin-9 is a protein that in humans is encoded by the CLDN9 gene.{{cite journal | vauthors = Peacock RE, Keen TJ, Inglehearn CF | title = Analysis of a human gene homologous to rat ventral prostate.1 protein | journal = Genomics | volume = 46 | issue = 3 | pages = 443–9 |date=Mar 1998 | pmid = 9441748 | doi = 10.1006/geno.1997.5033 }}{{cite journal | vauthors = Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T | title = The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus | journal = J Virol | volume = 82 | issue = 7 | pages = 3555–60 |date=Mar 2008 | pmid = 18234789 | pmc = 2268462 | doi = 10.1128/JVI.01977-07 }}{{cite web | title = Entrez Gene: CLDN9 claudin 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9080}} It belongs to the group of claudins.
This gene is expressed in the inner ear, olfactory epithelium, and anterior pituitary gland {{cite journal | vauthors = Higashi AY, Higashi T, Furuse K, Ozeki K, Furuse M, Chiba H | title = Claudin-9 constitutes tight junctions of folliclo-stellate cells in the anterior pituitary gland. | journal = Scientific Reports | volume = 11 | pages = 21642 |date=Nov 2021 | issue = 1 | pmid = 34737342 | doi = 10.1038/s41598-021-01004-z | pmc = 8568902 | bibcode = 2021NatSR..1121642H }} and is involved in hearing.[http://www.physorg.com/news170065521.html Gene discovery reveals a critical protein's function in hearing]{{cite journal | vauthors = Nakano Y, Kim SH, Kim HM, Sanneman JD, Zhang Y, Smith RJ, Marcus DC, Wangemann P, Nessler RA, Bánfi B | title = A claudin-9-based ion permeability barrier is essential for hearing. | journal = PLOS Genetics | volume = 5 | issue = 8 | pages = e1000610 |date=Aug 2009 | pmid = 19696885 | pmc=2720454| doi = 10.1371/journal.pgen.1000610 | doi-access = free }}{{cite journal | vauthors = Sineni CJ, Yildirim-Baylan M, Guo S, Camarena V, Wang G, Tokgoz-Yilmaz S, Duman D, Bademci G, Tekin M | title = A truncating CLDN9 variant if associated with autosomal recessive nonsyndromic hearing loss. | journal = Human Genetics | volume = 138 | issue = 10 | pages = 1071–1075 |date=Oct 2019 | pmid = 31175426 | doi = 10.1007/s00439-019-02037-1| pmc=6745279 }}
References
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External links
- {{UCSC gene info|CLDN9}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Kniesel U, Wolburg H |title=Tight junctions of the blood–brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57–76 |year= 2000 |pmid= 10690502 |doi=10.1023/A:1006995910836 |s2cid=26473781 |pmc=11537529 }}
- {{cite journal | vauthors=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93–8 |year= 2001 |pmid= 11247307 |doi=10.1034/j.1600-0854.2001.020203.x |doi-access= |s2cid=12132159 }}
- {{cite journal | vauthors=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285–93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 |s2cid=36524601 }}
- {{cite journal | vauthors=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531–6 |year= 2003 |pmid= 12231346 |doi=10.1016/S0955-0674(02)00362-9 }}
- {{cite journal | vauthors=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1–44 |year= 2003 |pmid= 12475568 |doi=10.1016/S0079-6107(02)00037-8 |doi-access= }}
- {{cite journal | vauthors=Yi X, Wang Y, Yu FS |title=Corneal epithelial tight junctions and their response to lipopolysaccharide challenge. |journal=Invest. Ophthalmol. Vis. Sci. |volume=41 |issue= 13 |pages= 4093–100 |year= 2000 |pmid= 11095601 }}
- {{cite journal | vauthors=Kiuchi-Saishin Y, Gotoh S, Furuse M |title=Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments. |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 4 |pages= 875–86 |year= 2002 |doi=10.1681/ASN.V134875 |pmid= 11912246 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Katoh M, Katoh M |title=CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 683–9 |year= 2004 |pmid= 12736707 |doi= 10.3892/ijmm.11.6.683}}
- {{cite journal | vauthors=Ban Y, Dota A, Cooper LJ |title=Tight junction-related protein expression and distribution in human corneal epithelium. |journal=Exp. Eye Res. |volume=76 |issue= 6 |pages= 663–9 |year= 2003 |pmid= 12742348 |doi=10.1016/S0014-4835(03)00054-X |display-authors=etal}}
- {{cite journal | vauthors=Kitajiri SI, Furuse M, Morita K |title=Expression patterns of claudins, tight junction adhesion molecules, in the inner ear. |journal=Hear. Res. |volume=187 |issue= 1–2 |pages= 25–34 |year= 2004 |pmid= 14698084 |doi=10.1016/S0378-5955(03)00338-1 |s2cid=31183039 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Zheng A, Yuan F, Li Y |title=Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus. |journal=J. Virol. |volume=81 |issue= 22 |pages= 12465–71 |year= 2007 |pmid= 17804490 |doi= 10.1128/JVI.01457-07 | pmc=2169001 |display-authors=etal}}
- {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | volume = 15 | issue = 2 | pages = 339–359 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 | pmc = 4777318 }}
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