CLEC1B
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
C-type lectin domain family 1 member B (i.e., CLEC-1b), also termed C-type lectin-like receptor 2 (i.e., CLEC-2),{{cite journal | vauthors = Meng D, Luo M, Liu B | title = The Role of CLEC-2 and Its Ligands in Thromboinflammation | journal = Frontiers in Immunology | volume = 12 | issue = | pages = 688643 | date = 2021 | pmid = 34177942 | pmc = 8220156 | doi = 10.3389/fimmu.2021.688643 | doi-access = free | url = }} is a protein that in humans is encoded by the CLEC1B gene.{{cite journal | vauthors = Colonna M, Samaridis J, Angman L | title = Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells | journal = Eur J Immunol | volume = 30 | issue = 2 | pages = 697–704 |date=Mar 2000 | pmid = 10671229 | doi = 10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M | doi-access = free }}{{cite journal | vauthors = Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E | title = A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex | journal = Eur J Immunol | volume = 31 | issue = 12 | pages = 3493–503 |date=Dec 2001 | pmid = 11745369 | doi =10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9 | s2cid = 42415487 }}{{cite web | title = Entrez Gene: CLEC1B C-type lectin domain family 1, member B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51266}}
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM]
References
{{reflist}}
External links
- {{UCSC gene info|CLEC1B}}
- {{UCSC gene info|CLEC2B}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Suzuki-Inoue K, Fuller GL, García A |title=A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2 |journal=Blood |volume=107 |issue= 2 |pages= 542–9 |year= 2006 |pmid= 16174766 |doi= 10.1182/blood-2005-05-1994 |s2cid=168505 |display-authors=etal|doi-access= }}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
- {{cite journal | vauthors=Watson AA, O'Callaghan CA |title=Crystallization and X-ray diffraction analysis of human CLEC-2 |journal=Acta Crystallographica Section F |volume=61 |issue= Pt 12 |pages= 1094–6 |year= 2006 |pmid= 16511244 |doi= 10.1107/S1744309105037991 | pmc=1978148 }}
- {{cite journal | vauthors=Scherer SE, Muzny DM, Buhay CJ |title=The finished DNA sequence of human chromosome 12 |journal=Nature |volume=440 |issue= 7082 |pages= 346–51 |year= 2006 |pmid= 16541075 |doi= 10.1038/nature04569 |bibcode=2006Natur.440..346S |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Chaipan C, Soilleux EJ, Simpson P |title=DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets |journal=J. Virol. |volume=80 |issue= 18 |pages= 8951–60 |year= 2006 |pmid= 16940507 |doi= 10.1128/JVI.00136-06 | pmc=1563896 |display-authors=etal}}
- {{cite journal | vauthors=Watson AA, Brown J, Harlos K |title=The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2 |journal=J. Biol. Chem. |volume=282 |issue= 5 |pages= 3165–72 |year= 2007 |pmid= 17132623 |doi= 10.1074/jbc.M610383200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Suzuki-Inoue K, Kato Y, Inoue O |title=Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells |journal=J. Biol. Chem. |volume=282 |issue= 36 |pages= 25993–6001 |year= 2007 |pmid= 17616532 |doi= 10.1074/jbc.M702327200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Watson AA, Eble JA, O'Callaghan CA |title=Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2|journal=Protein Science |volume=17|issue= 9|pages= 1611–6|year= 2008 |pmid= 18583525 |doi= 10.1110/ps.035568.108 | pmc=2525532}}
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{{PDB Gallery|geneid=51266}}
Category:Genes on human chromosome 12
{{gene-12-stub}}