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CLEC2B

{{Short description|Protein-coding gene in humans}}

{{Infobox_gene}}

C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene.{{cite journal | vauthors = Hamann J, Montgomery KT, Lau S, Kucherlapati R, van Lier RA | title = AICL: a new activation-induced antigen encoded by the human NK gene complex | journal = Immunogenetics | volume = 45 | issue = 5 | pages = 295–300 |date=Mar 1997 | pmid = 9038101 | doi =10.1007/s002510050208 | s2cid = 34214844 | url = http://dare.uva.nl/personal/pure/en/publications/aicl-a-new-activation-induced-antigen-encoded-by-the-human-nk-gene-complex(46585181-0595-4246-ab3e-0e846cf2e05f).html }}{{cite web | title = Entrez Gene: CLEC2B C-type lectin domain family 2, member B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9976}}

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) protein superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length nucleotide sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

References

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External links

  • {{UCSC gene info|CLEC2B}}

Further reading

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  • {{cite journal | author=Drickamer K |title=C-type lectin-like domains |journal=Curr. Opin. Struct. Biol. |volume=9 |issue= 5 |pages= 585–90 |year= 1999 |pmid= 10508765 |doi=10.1016/S0959-440X(99)00009-3 }}
  • {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | vauthors=Ebner S, Sharon N, Ben-Tal N |title=Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily |journal=Proteins |volume=53 |issue= 1 |pages= 44–55 |year= 2003 |pmid= 12945048 |doi= 10.1002/prot.10440 |s2cid=30955198 }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Renedo M |title=A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2 |journal=Genomics |volume=65 |issue= 2 |pages= 129–36 |year= 2000 |pmid= 10783260 |doi= 10.1006/geno.2000.6163 |name-list-style=vanc| author2=Arce I | author3=Montgomery K | display-authors=3 | last4=Roda-Navarro | first4=Pedro | last5=Lee | first5=Eunice | last6=Kucherlapati | first6=Raju | last7=Fernández-Ruiz | first7=Elena }}
  • {{cite journal | vauthors=Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S |title=Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank |journal=Gene |volume=228 |issue= 1–2 |pages= 161–7 |year= 1999 |pmid= 10072769 |doi=10.1016/S0378-1119(99)00004-9 }}
  • {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}

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