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CLEC4M

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene.{{cite journal | vauthors = Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S | title = Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank | journal = Gene | volume = 228 | issue = 1–2 | pages = 161–7 |date=Apr 1999 | pmid = 10072769 | doi =10.1016/S0378-1119(99)00004-9 }} CLEC4M has also been designated as CD299 (cluster of differentiation 299).

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.{{cite web | title = Entrez Gene: CLEC4M C-type lectin domain family 4, member M| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10332}}

References

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Further reading

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  • {{cite journal | vauthors=Baribaud F, Doms RW, Pöhlmann S |title=The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination? |journal=Expert Opin. Ther. Targets |volume=6 |issue= 4 |pages= 423–31 |year= 2006 |pmid= 12223058 |doi= 10.1517/14728222.6.4.423 |s2cid=21541850 }}
  • {{cite journal | author=Becker Y |title=HIV-1 gp120 binding to dendritic cell receptors mobilize the virus to the lymph nodes, but the induced IL-4 synthesis by FcepsilonRI+ hematopoietic cells damages the adaptive immunity--a review, hypothesis, and implications. |journal=Virus Genes |volume=29 |issue= 1 |pages= 147–65 |year= 2004 |pmid= 15215692 |doi= 10.1023/B:VIRU.0000032797.43537.d3 |s2cid=5666009 |doi-access=free }}
  • {{cite journal | vauthors=Lalor PF, Lai WK, Curbishley SM |title=Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo. |journal=World J. Gastroenterol. |volume=12 |issue= 34 |pages= 5429–39 |year= 2006 |pmid= 17006978 |pmc=4088223 |doi= 10.3748/wjg.v12.i34.5429|display-authors=etal |doi-access=free }}
  • {{cite journal | vauthors=Curtis BM, Scharnowske S, Watson AJ |title=Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 17 |pages= 8356–60 |year= 1992 |pmid= 1518869 |doi=10.1073/pnas.89.17.8356 | pmc=49917 |bibcode=1992PNAS...89.8356C |doi-access=free }}
  • {{cite journal | vauthors=Gattegno L, Ramdani A, Jouault T |title=Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1). |journal=AIDS Res. Hum. Retroviruses |volume=8 |issue= 1 |pages= 27–37 |year= 1992 |pmid= 1736938 |doi=10.1089/aid.1992.8.27 |display-authors=etal}}
  • {{cite journal | vauthors=Soilleux EJ, Barten R, Trowsdale J |title=DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. |journal=J. Immunol. |volume=165 |issue= 6 |pages= 2937–42 |year= 2000 |pmid= 10975799 |doi= 10.4049/jimmunol.165.6.2937|doi-access=free }}
  • {{cite journal | vauthors=Pöhlmann S, Soilleux EJ, Baribaud F |title=DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 5 |pages= 2670–5 |year= 2001 |pmid= 11226297 |doi= 10.1073/pnas.051631398 | pmc=30196 |bibcode=2001PNAS...98.2670P |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Bashirova AA, Geijtenbeek TB, van Duijnhoven GC |title=A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. |journal=J. Exp. Med. |volume=193 |issue= 6 |pages= 671–8 |year= 2001 |pmid= 11257134 |doi=10.1084/jem.193.6.671 | pmc=2193415 |display-authors=etal}}
  • {{cite journal | vauthors=Mummidi S, Catano G, Lam L |title=Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 33196–212 |year= 2001 |pmid= 11337487 |doi=10.1074/jbc.M009807200 |display-authors=etal|doi-access= free}}
  • {{cite journal | vauthors=Mitchell DA, Fadden AJ, Drickamer K |title=A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28939–45 |year= 2001 |pmid= 11384997 |doi=10.1074/jbc.M104565200 |doi-access=free }}
  • {{cite journal | vauthors=Feinberg H, Mitchell DA, Drickamer K, Weis WI |title=Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR. |journal=Science |volume=294 |issue= 5549 |pages= 2163–6 |year= 2002 |pmid= 11739956 |doi= 10.1126/science.1066371 |s2cid=25046581 }}
  • {{cite journal | vauthors=Alvarez CP, Lasala F, Carrillo J |title=C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. |journal=J. Virol. |volume=76 |issue= 13 |pages= 6841–4 |year= 2002 |pmid= 12050398 |doi=10.1128/JVI.76.13.6841-6844.2002 | pmc=136246 |display-authors=etal}}
  • {{cite journal | vauthors=Soilleux EJ, Morris LS, Rushbrook S |title=Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity. |journal=Hum. Pathol. |volume=33 |issue= 6 |pages= 652–9 |year= 2002 |pmid= 12152166 |doi=10.1053/hupa.2002.124036 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Lin G, Simmons G, Pöhlmann S |title=Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR. |journal=J. Virol. |volume=77 |issue= 2 |pages= 1337–46 |year= 2003 |pmid= 12502850 |doi=10.1128/JVI.77.2.1337-1346.2003 | pmc=140807 |display-authors=etal}}
  • {{cite journal | vauthors=Pöhlmann S, Zhang J, Baribaud F |title=Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. |journal=J. Virol. |volume=77 |issue= 7 |pages= 4070–80 |year= 2003 |pmid= 12634366 |doi=10.1128/JVI.77.7.4070-4080.2003 | pmc=150620 |display-authors=etal}}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Engering A, van Vliet SJ, Hebeda K |title=Dynamic populations of dendritic cell-specific ICAM-3 grabbing nonintegrin-positive immature dendritic cells and liver/lymph node-specific ICAM-3 grabbing nonintegrin-positive endothelial cells in the outer zones of the paracortex of human lymph nodes. |journal=Am. J. Pathol. |volume=164 |issue= 5 |pages= 1587–95 |year= 2004 |pmid= 15111305 |doi= 10.1016/S0002-9440(10)63717-0| pmc=1615649 |display-authors=etal}}

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{{PDB Gallery|geneid=10332}}

External links

  • {{MeshName|CLEC4M+protein,+human}}
  • {{UCSC genome browser|CLEC4M}}
  • {{UCSC gene details|CLEC4M}}

{{NLM content}}

{{Clusters of differentiation}}

Category:Clusters of differentiation

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