CLIC1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{Infobox_gene}}
Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.{{cite journal | vauthors = Valenzuela SM, Martin DK, Por SB, Robbins JM, Warton K, Bootcov MR, Schofield PR, Campbell TJ, Breit SN | title = Molecular cloning and expression of a chloride ion channel of cell nuclei | journal = J Biol Chem | volume = 272 | issue = 19 | pages = 12575–82 |date=Jun 1997 | pmid = 9139710 | doi =10.1074/jbc.272.19.12575 | doi-access = free }}{{cite web | title = Entrez Gene: CLIC1 chloride intracellular channel 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1192}}
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
Interactions
CLIC1 has been shown to interact with TRAPPC2.{{cite journal |last=Fan |first=Libin |author2=Yu Wei |author3=Zhu Xueliang |date=Apr 2003 |title=Interaction of Sedlin with chloride intracellular channel proteins |journal=FEBS Lett. |volume=540 |issue=1–3 |pages=77–80 |location = Netherlands| issn = 0014-5793| pmid = 12681486 |doi=10.1016/S0014-5793(03)00228-X |s2cid=8573651 |doi-access=free |bibcode=2003FEBSL.540...77F }}
See also
References
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Further reading
{{refbegin | 2}}
- {{cite journal | author=Singh H |title=Two decades with dimorphic Chloride Intracellular Channels (CLICs) |journal=FEBS Letters|volume= 584|issue= 10|pages= 2112–21|year= 2010 |pmid= 20226783 |doi=10.1016/j.febslet.2010.03.013 |s2cid=21056278 |doi-access= |bibcode=2010FEBSL.584.2112S }}
- {{cite journal | vauthors=Okubo K, Hori N, Matoba R |title=Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression |journal=Nat. Genet. |volume=2 |issue= 3 |pages= 173–9 |year= 1994 |pmid= 1345164 |doi= 10.1038/ng1192-173 |s2cid=35309579 |display-authors=etal}}
- {{cite journal | vauthors=Frigerio JM, Berthézène P, Garrido P |title=Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing |journal=Hum. Mol. Genet. |volume=4 |issue= 1 |pages= 37–43 |year= 1995 |pmid= 7711732 |doi=10.1093/hmg/4.1.37 |display-authors=etal}}
- {{cite journal | vauthors=Singh H, Ashley RH |title=Redox Regulation of CLIC1 by Cysteine Residues Associated with the Putative Channel Pore |journal=Biophys. J.|volume=90 |issue= 5 |pages= 1628–1638 |year= 2006 |pmid= 16339885 |doi=10.1529/biophysj.105.072678 | pmc=1367314 |bibcode=2006BpJ....90.1628S }}
- {{cite journal | vauthors=Liew CC, Hwang DM, Fung YW |title=A catalogue of genes in the cardiovascular system as identified by expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 22 |pages= 10645–9 |year= 1994 |pmid= 7938007 |doi=10.1073/pnas.91.22.10645 | pmc=45078 |bibcode=1994PNAS...9110645L |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors=Heiss NS, Poustka A |title=Genomic structure of a novel chloride channel gene, CLIC2, in Xq28 |journal=Genomics |volume=45 |issue= 1 |pages= 224–8 |year= 1997 |pmid= 9339381 |doi= 10.1006/geno.1997.4922 }}
- {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal | vauthors=Tulk BM, Edwards JC |title=NCC27, a homolog of intracellular Cl− channel p64, is expressed in brush border of renal proximal tubule |journal=Am. J. Physiol. |volume=274 |issue= 6 Pt 2 |pages= F1140–9 |year= 1998 |doi=10.1152/ajprenal.1998.274.6.F1140 |pmid= 9841507 |s2cid=39652235 |doi-access=free }}
- {{cite journal | vauthors=Chuang JZ, Milner TA, Zhu M, Sung CH |title=A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons |journal=J. Neurosci. |volume=19 |issue= 8 |pages= 2919–28 |year= 1999 |pmid= 10191309 |doi=10.1523/JNEUROSCI.19-08-02919.1999|pmc=6782274 |doi-access=free }}
- {{cite journal | vauthors=Ribas G, Neville M, Wixon JL |title=Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region |journal=J. Immunol. |volume=163 |issue= 1 |pages= 278–87 |year= 1999 |doi=10.4049/jimmunol.163.1.278 |pmid= 10384126 |display-authors=etal}}
- {{cite journal | vauthors=Berryman M, Bretscher A |title=Identification of a Novel Member of the Chloride Intracellular Channel Gene Family (CLIC5) That Associates with the Actin Cytoskeleton of Placental Microvilli |journal=Mol. Biol. Cell |volume=11 |issue= 5 |pages= 1509–21 |year= 2000 |pmid= 10793131 | pmc=14863 |doi=10.1091/mbc.11.5.1509}}
- {{cite journal | vauthors=Tonini R, Ferroni A, Valenzuela SM |title=Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells |journal=FASEB J. |volume=14 |issue= 9 |pages= 1171–8 |year= 2000 |doi=10.1096/fasebj.14.9.1171 |doi-access=free |pmid= 10834939 |s2cid=30652670 |display-authors=etal}}
- {{cite journal | vauthors=Valenzuela SM, Mazzanti M, Tonini R |title=The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle |journal=J. Physiol. |volume=529 |issue= 3|pages= 541–52 |year= 2001 |pmid= 11195932 | pmc=2270212 |doi=10.1111/j.1469-7793.2000.00541.x|display-authors=etal}}
- {{cite journal | vauthors=Harrop SJ, DeMaere MZ, Fairlie WD |title=Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44993–5000 |year= 2002 |pmid= 11551966 |doi= 10.1074/jbc.M107804200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Warton K, Tonini R, Fairlie WD |title=Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1 |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26003–11 |year= 2002 |pmid= 11978800 |doi= 10.1074/jbc.M203666200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Shanks RA, Larocca MC, Berryman M |title=AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40973–80 |year= 2002 |pmid= 12163479 |doi= 10.1074/jbc.M112277200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Fan L, Yu W, Zhu X |title=Interaction of Sedlin with chloride intracellular channel proteins |journal=FEBS Lett. |volume=540 |issue= 1–3 |pages= 77–80 |year= 2003 |pmid= 12681486 |doi=10.1016/S0014-5793(03)00228-X |s2cid=8573651 |doi-access=free |bibcode=2003FEBSL.540...77F }}
- {{cite journal | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |bibcode=2003Natur.425..805M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Littler DR, Harrop SJ, Fairlie WD |title=The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 9298–305 |year= 2004 |pmid= 14613939 |doi= 10.1074/jbc.M308444200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Singh H, Cousin MA, Ashley RH |title=Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin |journal=FEBS J.|volume=274 |issue= 24 |pages= 6306–6316 |year= 2007 |pmid= 18028448 |doi=10.1111/j.1742-4658.2007.06145.x |s2cid=22494250 }}
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External links
- {{MeshName|CLIC1+protein,+human}}
- {{UCSC gene info|CLIC1}}
{{NLM content}}
{{PDB Gallery|geneid=1192}}
{{Ion channels|g4}}
{{membrane-protein-stub}}