CLINT1

The CLINT1 protein binds to the terminal domain of the clathrin heavy chain and stimulates clathrin cage vesicle assembly. Clathrin coated vesicles enable neurotransmitter receptors and other proteins to be endocytosed or taken up across neuronal membranes and across the membranes of other types of cells. This enables a turnover of neuroreceptors or other proteins to be maintained and thus the numbers of receptors can be fine tuned.

The CLINT1 gene has been shown to be involved in the genetic aetiology of schizophrenia in four studies {{cite journal | vauthors = Pimm J, McQuillin A, Thirumalai S, Lawrence J, Quested D, Bass N, Lamb G, Moorey H, Datta SR, Kalsi G, Badacsonyi A, Kelly K, Morgan J, Punukollu B, Curtis D, Gurling H | title = The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia | journal = Am. J. Hum. Genet. | volume = 76 | issue = 5 | pages = 902–7 |date=May 2005 | pmid = 15793701 | pmc = 1199380 | doi = 10.1086/430095 }}{{cite journal | vauthors = Gurling H, Pimm J, McQuillin A | title = Replication of genetic association studies between markers at the Epsin 4 gene locus and schizophrenia in two Han Chinese samples | journal = Schizophr. Res. | volume = 89 | issue = 1–3 | pages = 357–9 |date=January 2007 | pmid = 17070672 | doi = 10.1016/j.schres.2006.08.024 | s2cid = 43407088 }}{{cite journal | vauthors = Tang RQ, Zhao XZ, Shi YY, Tang W, Gu NF, Feng GY, Xing YL, Zhu SM, Sang H, Liang PJ, He L | title = Family-based association study of Epsin 4 and Schizophrenia | journal = Mol. Psychiatry | volume = 11 | issue = 4 | pages = 395–9 |date=April 2006 | pmid = 16402136 | doi = 10.1038/sj.mp.4001780 | doi-access = free }}{{cite journal | vauthors = Liou YJ, Lai IC, Wang YC, Bai YM, Lin CC, Lin CY, Chen TT, Chen JY | title = Genetic analysis of the human ENTH (Epsin 4) gene and schizophrenia | journal = Schizophr. Res. | volume = 84 | issue = 2–3 | pages = 236–43 |date=June 2006 | pmid = 16616458 | doi = 10.1016/j.schres.2006.02.021 | s2cid = 23934037 }}{{cite journal | vauthors = Escamilla M, Lee BD, Ontiveros A, Raventos H, Nicolini H, Mendoza R, Jerez A, Munoz R, Medina R, Figueroa A, Walss-Bass C, Armas R, Contreras S, Ramirez ME, Dassori A | title = The epsin 4 gene is associated with psychotic disorders in families of Latin American origin | journal = Schizophr. Res. | volume = 106 | issue = 2–3 | pages = 253–7 |date=December 2008 | pmid = 18929466 | doi = 10.1016/j.schres.2008.09.005 | s2cid = 24978042 }} It is known that the antipsychotic drugs chlorpromazine and clozapine stabilise clathrin coated vesicles{{cite journal | vauthors = Phonphok Y, Rosenthal KS | title = Stabilization of clathrin coated vesicles by amantadine, tromantadine and other hydrophobic amines | journal = FEBS Lett. | volume = 281 | issue = 1–2 | pages = 188–90 |date=April 1991 | pmid = 1901801 | doi = 10.1016/0014-5793(91)80390-O | s2cid = 8197032 | doi-access = free }}{{cite journal | vauthors = Claing A, Perry SJ, Achiriloaie M, Walker JK, Albanesi JP, Lefkowitz RJ, Premont RT| title = Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 3 | pages = 1119–24 |date=February 2000 | pmid = 10655494 | pmc = 15541 | doi = 10.1073/pnas.97.3.1119| bibcode = 2000PNAS...97.1119C | doi-access = free }} and this may be one reason why antipsychotic drugs are effective in treating delusions, auditory hallucinations and many of the other symptoms of schizophrenia.

CLINT1 has been shown to interact with GGA2.

{{Reflist|2}}

• {{UCSC gene info|CLINT1}}

{{refbegin | 2}}

• {{cite journal | vauthors=Nagase T, Seki N, Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=3 |issue= 1 |pages= 17–24 |year= 1996 |pmid= 8724849 |doi=10.1093/dnares/3.1.17 |display-authors=etal|doi-access=free }}
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• {{cite journal | vauthors=Wasiak S, Legendre-Guillemin V, Puertollano R |title=Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. |journal=J. Cell Biol. |volume=158 |issue= 5 |pages= 855–62 |year= 2002 |pmid= 12213833 |doi= 10.1083/jcb.200205078 | pmc=2173151 |display-authors=etal}}
• {{cite journal | vauthors=Kalthoff C, Groos S, Kohl R |title=Clint: a novel clathrin-binding ENTH-domain protein at the Golgi. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4060–73 |year= 2003 |pmid= 12429846 |doi= 10.1091/mbc.E02-03-0171 | pmc=133614 |display-authors=etal}}
• {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Mills IG, Praefcke GJ, Vallis Y |title=EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. |journal=J. Cell Biol. |volume=160 |issue= 2 |pages= 213–22 |year= 2003 |pmid= 12538641 |doi= 10.1083/jcb.200208023 | pmc=2172650 |display-authors=etal}}
• {{cite journal | vauthors=Hirst J, Motley A, Harasaki K |title=EpsinR: an ENTH domain-containing protein that interacts with AP-1. |journal=Mol. Biol. Cell |volume=14 |issue= 2 |pages= 625–41 |year= 2003 |pmid= 12589059 |doi= 10.1091/mbc.E02-09-0552 | pmc=149997 |display-authors=etal}}
• {{cite journal | vauthors=Wasiak S, Denisov AY, Han Z |title=Characterization of a gamma-adaptin ear-binding motif in enthoprotin. |journal=FEBS Lett. |volume=555 |issue= 3 |pages= 437–42 |year= 2004 |pmid= 14675752 |doi=10.1016/S0014-5793(03)01299-7 |s2cid=84390010 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Saint-Pol A, Yélamos B, Amessou M |title=Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes. |journal=Dev. Cell |volume=6 |issue= 4 |pages= 525–38 |year= 2004 |pmid= 15068792 |doi=10.1016/S1534-5807(04)00100-5 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |display-authors=etal|doi-access=free |bibcode=2004CBio...14.1436J }}
• {{cite journal | vauthors=Hirst J, Miller SE, Taylor MJ |title=EpsinR is an adaptor for the SNARE protein Vti1b. |journal=Mol. Biol. Cell |volume=15 |issue= 12 |pages= 5593–602 |year= 2005 |pmid= 15371541 |doi= 10.1091/mbc.E04-06-0468 | pmc=532037 |display-authors=etal}}
• {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
• {{cite journal | vauthors=Pimm J, McQuillin A, Thirumalai S |title=The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia. |journal=Am. J. Hum. Genet. |volume=76 |issue= 5 |pages= 902–7 |year= 2005 |pmid= 15793701 |doi= 10.1086/430095 | pmc=1199380 |display-authors=etal}}
• {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
• {{cite journal | vauthors=Tang RQ, Zhao XZ, Shi YY |title=Family-based association study of Epsin 4 and Schizophrenia. |journal=Mol. Psychiatry |volume=11 |issue= 4 |pages= 395–9 |year= 2006 |pmid= 16402136 |doi= 10.1038/sj.mp.4001780 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }}

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{{PDB Gallery|geneid=9685}}