CNOT4

The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]. Diseases associated with CNOT4 include Adenoiditis.{{Cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=CNOT4|website=www.genecards.org|access-date=2019-06-21|title=CNOT4 Gene - GeneCards | CNOT4 Protein | CNOT4 Antibody}}

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• {{cite journal | vauthors = Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M | title = Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells | journal = FASEB Journal | volume = 26 | issue = 3 | pages = 1239–50 | date = March 2012 | pmid = 22159038 | doi = 10.1096/fj.11-195875 | doi-access = free | s2cid = 25618632 }}
• {{cite journal | vauthors = Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT | title = An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair | journal = Journal of Molecular Biology | volume = 337 | issue = 1 | pages = 157–65 | date = March 2004 | pmid = 15001359 | doi = 10.1016/j.jmb.2004.01.031 }}
• {{cite journal | vauthors = Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT | title = Human Ccr4-Not complexes contain variable deadenylase subunits | journal = The Biochemical Journal | volume = 422 | issue = 3 | pages = 443–53 | date = September 2009 | pmid = 19558367 | doi = 10.1042/BJ20090500 | url = https://hal.archives-ouvertes.fr/hal-00479183/file/PEER_stage2_10.1042%252FBJ20090500.pdf }}
• {{cite journal | vauthors = Albert TK, Hanzawa H, Legtenberg YI, de Ruwe MJ, van den Heuvel FA, Collart MA, Boelens R, Timmers HT | title = Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex | journal = The EMBO Journal | volume = 21 | issue = 3 | pages = 355–64 | date = February 2002 | pmid = 11823428 | pmc = 125831 | doi = 10.1093/emboj/21.3.355 }}
• {{cite journal | vauthors = Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R | title = Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches | journal = Structure | volume = 12 | issue = 4 | pages = 633–44 | date = April 2004 | pmid = 15062086 | doi = 10.1016/j.str.2004.03.004 | doi-access = free }}
• {{cite journal | vauthors = Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K | title = Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants | journal = Molecular Vision | volume = 8 | pages = 205–20 | date = June 2002 | pmid = 12107410 }}
• {{cite journal | vauthors = Mersman DP, Du HN, Fingerman IM, South PF, Briggs SD | title = Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression | journal = Genes & Development | volume = 23 | issue = 8 | pages = 951–62 | date = April 2009 | pmid = 19346402 | pmc = 2675863 | doi = 10.1101/gad.1769209 }}
• {{cite journal | vauthors = Hanzawa H, de Ruwe MJ, Albert TK, van Der Vliet PC, Timmers HT, Boelens R | title = The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers | journal = The Journal of Biological Chemistry | volume = 276 | issue = 13 | pages = 10185–90 | date = March 2001 | pmid = 11087754 | doi = 10.1074/jbc.M009298200 | doi-access = free }}
• {{cite journal | vauthors = Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT | title = Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits | journal = Nucleic Acids Research | volume = 28 | issue = 3 | pages = 809–17 | date = February 2000 | pmid = 10637334 | pmc = 102560 | doi = 10.1093/nar/28.3.809 }}

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Category:Genes

Category:Human proteins

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