CNOT6L
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
CCR4-NOT transcription complex subunit 6 like is a protein that in humans is encoded by the CNOT6L gene.
{{cite web
| title = Entrez Gene: CCR4-NOT transcription complex subunit 6 like
| url = http://www.ncbi.nlm.nih.gov/gene/246175
| access-date = 2020-04-15
}} It is a paralog of CNOT6 and therefore a potential subunit of the CCR4-Not deadenylase complex.
References
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Further reading
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- {{cite journal |vauthors=Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T |title=Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth |journal=Mol. Cell. Biol. |volume=27 |issue=13 |pages=4980–90 |date=July 2007 |pmid=17452450 |pmc=1951489 |doi=10.1128/MCB.02304-06 }}
- {{cite journal |vauthors=Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR |title=Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score |journal=Mol. Med. |volume=16 |issue=7–8 |pages=247–53 |date=2010 |pmid=20379614 |pmc=2896464 |doi=10.2119/molmed.2009.00159 }}
- {{cite journal |vauthors=Wang H, Morita M, Yang X, Suzuki T, Yang W, Wang J, Ito K, Wang Q, Zhao C, Bartlam M, Yamamoto T, Rao Z |title=Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity |journal=EMBO J. |volume=29 |issue=15 |pages=2566–76 |date=August 2010 |pmid=20628353 |pmc=2928688 |doi=10.1038/emboj.2010.152 }}
- {{cite journal |vauthors=Naylor MG, Weiss ST, Lange C |title=A Bayesian approach to genetic association studies with family-based designs |journal=Genet. Epidemiol. |volume=34 |issue=6 |pages=569–74 |date=September 2010 |pmid=20818722 |pmc=3349938 |doi=10.1002/gepi.20513 }}
- {{cite journal |vauthors=Mittal S, Aslam A, Doidge R, Medica R, Winkler GS |title=The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence |journal=Mol. Biol. Cell |volume=22 |issue=6 |pages=748–58 |date=March 2011 |pmid=21233283 |pmc=3057700 |doi=10.1091/mbc.E10-11-0898 }}
- {{cite journal |vauthors=Zhou W, Thiery JP |title=Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1 |journal=J. Cell Sci. |volume=126 |issue=Pt 12 |pages=2740–6 |date=June 2013 |pmid=23591815 |doi=10.1242/jcs.126367 |doi-access=free }}
- {{cite journal |vauthors=Polesskaya A, Pinna G, Sassi Y, Vandamme M, Bigot A, Mouly V, Morozova N, Harel-Bellan A, Degerny C |title=Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation |journal=Biochim. Biophys. Acta |volume=1863 |issue=2 |pages=263–70 |date=February 2016 |pmid=26608607 |doi=10.1016/j.bbamcr.2015.11.018 |doi-access=free }}
- {{cite journal |vauthors=Zhang Q, Yan D, Guo E, Ding B, Yang W, Liu R, Yamamoto T, Bartlam M |title=Structural basis for inhibition of the deadenylase activity of human CNOT6L |journal=FEBS Lett. |volume=590 |issue=8 |pages=1270–9 |date=April 2016 |pmid=27013054 |doi=10.1002/1873-3468.12160 |doi-access=free }}
- {{cite journal |vauthors=Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N |title=Hepatic posttranscriptional network {{sic|comprised |hide=y|of}} CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=116 |issue=16 |pages=7973–7981 |date=April 2019 |pmid=30926667 |pmc=6475422 |doi=10.1073/pnas.1816023116 |doi-access=free }}
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