CNOT9

This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-Not deadenylation complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012].

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• {{cite journal |vauthors=Hiroi N, Ito T, Yamamoto H, Ochiya T, Jinno S, Okayama H |title=Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation |journal=EMBO J. |volume=21 |issue=19 |pages=5235–44 |date=October 2002 |pmid=12356739 |pmc=129043 |doi=10.1093/emboj/cdf521 }}
• {{cite journal |vauthors=Garapaty S, Mahajan MA, Samuels HH |title=Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1 |journal=J. Biol. Chem. |volume=283 |issue=11 |pages=6806–16 |date=March 2008 |pmid=18180299 |doi=10.1074/jbc.M706986200 |doi-access=free }}
• {{cite journal |vauthors=Ajiro M, Katagiri T, Ueda K, Nakagawa H, Fukukawa C, Lin ML, Park JH, Nishidate T, Daigo Y, Nakamura Y |title=Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells |journal=Int. J. Oncol. |volume=35 |issue=4 |pages=673–81 |date=October 2009 |pmid=19724902 }}
• {{cite journal |vauthors=Ajiro M, Nishidate T, Katagiri T, Nakamura Y |title=Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis |journal=Int. J. Oncol. |volume=37 |issue=5 |pages=1085–93 |date=November 2010 |pmid=20878056 |doi=10.3892/ijo_00000760 |doi-access=free }}
• {{cite journal |vauthors=Mathys H, Basquin J, Ozgur S, Czarnocki-Cieciura M, Bonneau F, Aartse A, Dziembowski A, Nowotny M, Conti E, Filipowicz W |title=Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression |journal=Mol. Cell |volume=54 |issue=5 |pages=751–65 |date=June 2014 |pmid=24768538 |doi=10.1016/j.molcel.2014.03.036 |doi-access=free }}
• {{cite journal |vauthors=Chen Y, Boland A, Kuzuoğlu-Öztürk D, Bawankar P, Loh B, Chang CT, Weichenrieder O, Izaurralde E |title=A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing |journal=Mol. Cell |volume=54 |issue=5 |pages=737–50 |date=June 2014 |pmid=24768540 |doi=10.1016/j.molcel.2014.03.034 |doi-access=free }}
• {{cite journal |vauthors=Wong SQ, Behren A, Mar VJ, Woods K, Li J, Martin C, Sheppard KE, Wolfe R, Kelly J, Cebon J, Dobrovic A, McArthur GA |title=Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma |journal=Oncotarget |volume=6 |issue=2 |pages=1115–27 |date=January 2015 |pmid=25544760 |pmc=4359221 |doi=10.18632/oncotarget.2747 }}
• {{cite journal |vauthors=Bulbrook D, Brazier H, Mahajan P, Kliszczak M, Fedorov O, Marchese FP, Aubareda A, Chalk R, Picaud S, Strain-Damerell C, Filippakopoulos P, Gileadi O, Clark AR, Yue WW, Burgess-Brown NA, ((Dean JLE)) |title=Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment |journal=J. Mol. Biol. |volume=430 |issue=5 |pages=722–736 |date=March 2018 |pmid=29291391 |doi=10.1016/j.jmb.2017.12.018 |url=http://pure-oai.bham.ac.uk/ws/files/47305708/Bulbrook_et_al_Tryptophan_mediated_interactions_JMB_2017.pdf}}
• {{cite journal |vauthors=Han J, Yu J, Dai Y, Li J, Guo M, Song J, Zhou X |title=Overexpression of miR-361-5p in triple-negative breast cancer (TNBC) inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway |journal=Bosn J Basic Med Sci |volume=19 |issue=1 |pages=52–59 |date=February 2019 |pmid=29924958 |pmc=6387672 |doi=10.17305/bjbms.2018.3399 }}

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