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CNO (gene)

{{Short description|Protein-coding gene in humans}}

{{Infobox_gene}}

Protein cappuccino homolog is a protein that in humans is encoded by the CNO gene.{{cite journal | vauthors = Ciciotte SL, Gwynn B, Moriyama K, Huizing M, Gahl WA, Bonifacino JS, Peters LL | title = Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1) | journal = Blood | volume = 101 | issue = 11 | pages = 4402–7 |date=May 2003 | pmid = 12576321 | doi = 10.1182/blood-2003-01-0020 | url = http://www.bloodjournal.org/cgi/content/abstract/101/11/4402 | doi-access = free }}{{cite journal | vauthors = Gwynn B, Ciciotte SL, Hunter SJ, Washburn LL, Smith RS, Andersen SG, Swank RT, Dell'Angelica EC, Bonifacino JS, Eicher EM, Peters LL | title = Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism | journal = Blood | volume = 96 | issue = 13 | pages = 4227–35 |date=Dec 2000 | pmid = 11110696 | doi = 10.1182/blood.V96.13.4227}}{{cite web | title = Entrez Gene: CNO cappuccino homolog (mouse)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55330}}

This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and is a model for Hermansky–Pudlak syndrome. The encoded protein may play a role in intracellular vesicular trafficking.

Interactions

CNO (gene) has been shown to interact with BLOC1S2{{cite journal |last=Starcevic |first=Marta |author2=Dell'Angelica Esteban C |date=Jul 2004 |title=Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1) |journal=J. Biol. Chem. |volume=279 |issue=27 |pages=28393–401 | issn = 0021-9258| pmid = 15102850 |doi = 10.1074/jbc.M402513200 |doi-access=free }} and PLDN.

References

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External links

  • {{UCSC gene info|BLOC1S4}}

Further reading

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  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Starcevic M, Dell'Angelica EC |title=Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28393–401 |year= 2004 |pmid= 15102850 |doi= 10.1074/jbc.M402513200 |doi-access= free }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Li W, Zhang Q, Oiso N |title=Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). |journal=Nat. Genet. |volume=35 |issue= 1 |pages= 84–9 |year= 2003 |pmid= 12923531 |doi= 10.1038/ng1229 | pmc=2860733 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Moriyama K, Bonifacino JS |title=Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles. |journal=Traffic |volume=3 |issue= 9 |pages= 666–77 |year= 2003 |pmid= 12191018 |doi=10.1034/j.1600-0854.2002.30908.x |s2cid=29888859 |doi-access=free }}

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