COG5
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Conserved oligomeric Golgi complex subunit 5 is a protein that in humans is encoded by the COG5 gene.{{cite journal | vauthors = Walter DM, Paul KS, Waters MG | title = Purification and characterization of a novel 13 S hetero-oligomeric protein complex that stimulates in vitro Golgi transport | journal = J Biol Chem | volume = 273 | issue = 45 | pages = 29565–76 |date=Dec 1998 | pmid = 9792665 | doi =10.1074/jbc.273.45.29565 | doi-access = free }}{{cite journal | vauthors = Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG | title = Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function | journal = J Cell Biol | volume = 157 | issue = 3 | pages = 405–15 |date=Apr 2002 | pmid = 11980916 | pmc = 2173297 | doi = 10.1083/jcb.200202016 }}{{cite web | title = Entrez Gene: COG5 component of oligomeric golgi complex 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10466}}
Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG5 (Ungar et al., 2002).[supplied by OMIM]
Interactions
COG5 has been shown to interact with COG7{{cite journal |last=Loh |first=Eva |author2=Hong Wanjin |date=Jun 2004 |title=The binary interacting network of the conserved oligomeric Golgi tethering complex |journal=J. Biol. Chem. |volume=279 |issue=23 |pages=24640–8 |location = United States| issn = 0021-9258| pmid = 15047703 |doi = 10.1074/jbc.M400662200 |doi-access=free }} and COG4.
References
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Further reading
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- {{cite journal | vauthors=Chen X, Bykhovskaya Y, Tidow N |title=The familial mediterranean fever protein interacts and colocalizes with a putative Golgi transporter |journal=Proc. Soc. Exp. Biol. Med. |volume=224 |issue= 1 |pages= 32–40 |year= 2000 |pmid= 10782044 |doi=10.1046/j.1525-1373.2000.22362.x |display-authors=etal}}
- {{cite journal | vauthors=Loh E, Hong W |title=Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21955–61 |year= 2002 |pmid= 11929878 |doi= 10.1074/jbc.M202326200 |doi-access= free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |display-authors=etal|bibcode=2003Natur.424..157H |doi-access=free }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Loh E, Hong W |title=The binary interacting network of the conserved oligomeric Golgi tethering complex |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24640–8 |year= 2004 |pmid= 15047703 |doi= 10.1074/jbc.M400662200 |doi-access= free }}
- {{cite journal | vauthors=Oka T, Vasile E, Penman M |title=Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells |journal=J. Biol. Chem. |volume=280 |issue= 38 |pages= 32736–45 |year= 2005 |pmid= 16051600 |doi= 10.1074/jbc.M505558200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
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External links
- [https://www.ncbi.nlm.nih.gov/books/NBK1332/ GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview]
- {{UCSC gene info|COG5}}
{{gene-7-stub}}