COMPASS complex
{{Short description|Protein complex}}
Complex Proteins Associated with Set1, also known as COMPASS, is a conserved protein complex playing a major role as a H3K4me3 methylase in eukaryotes.{{Cite journal|title=The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis|first=Ali|last=Shilatifard|date=December 10, 2012|journal=Annual Review of Biochemistry|volume=81|issue=1|pages=65–95|doi=10.1146/annurev-biochem-051710-134100|pmid=22663077|pmc=4010150}} Since it was first identified in 2001,{{Cite journal|title=COMPASS: A complex of proteins associated with a trithorax-related SET domain protein|first1=Trissa|last1=Miller|first2=Nevan J.|last2=Krogan|first3=Jim|last3=Dover|first4=H.|last4=Erdjument-Bromage|first5=Paul|last5=Tempst|first6=Mark|last6=Johnston|first7=Jack F.|last7=Greenblatt|first8=Ali|last8=Shilatifard|date=November 6, 2001|journal=Proceedings of the National Academy of Sciences|volume=98|issue=23|pages=12902–12907|doi=10.1073/pnas.231473398|pmid=11687631|pmc=60797|bibcode=2001PNAS...9812902M|doi-access=free}} other members of the COMPASS family of methylases with different functions have been discovered, in particular in humans.
The COMPASS complex, or similar protein complexes, have been identified in species ranging from single-celled fungi to humans.{{Cite journal |last1=Takahashi |first1=Yoh-hei |last2=Westfield |first2=Gerwin H. |last3=Oleskie |first3=Austin N. |last4=Trievel |first4=Raymond C. |last5=Shilatifard |first5=Ali |last6=Skiniotis |first6=Georgios |date=2011-12-20 |title=Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human |journal=Proceedings of the National Academy of Sciences |language=en |volume=108 |issue=51 |pages=20526–20531 |doi=10.1073/pnas.1109360108 |issn=0027-8424 |pmc=3251153 |pmid=22158900|doi-access=free |bibcode=2011PNAS..10820526T }} They play an important regulatory role in many essential biological processes including DNA repair, the progression of the cell cycle, and transcription through the methylenation of histone lysines.
The COMPASS complex is an example of a trithorax-group protein. The MLL1/SET domain associated with the COMPASS complex have crystal structure. The gene Cps50 coordinates the construction of COMPASS.{{Cite journal |last1=Qu |first1=Qianhui |last2=Takahashi |first2=Yoh-hei |last3=Yang |first3=Yidai |last4=Hu |first4=Hongli |last5=Zhang |first5=Yan |last6=Brunzelle |first6=Joseph S. |last7=Couture |first7=Jean-Francois |last8=Shilatifard |first8=Ali |last9=Skiniotis |first9=Georgios |date=2018-08-23 |title=Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex |journal=Cell |language=en |volume=174 |issue=5 |pages=1117–1126.e12 |doi=10.1016/j.cell.2018.07.020 |pmid=30100186 |pmc=6108936 |issn=0092-8674}}