COPB2

The Golgi coatomer complex (see MIM 601924) constitutes the coat of non-clathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM]

COPB2 has been shown to interact with:

• COPB1,{{cite journal | vauthors = Eugster A, Frigerio G, Dale M, Duden R | title = COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP | journal = EMBO J. | volume = 19 | issue = 15 | pages = 3905–17 | date = August 2000 | pmid = 10921873 | pmc = 306616 | doi = 10.1093/emboj/19.15.3905 }}{{cite journal | vauthors = Lowe M, Kreis TE | title = In vivo assembly of coatomer, the COP-I coat precursor | journal = J. Biol. Chem. | volume = 271 | issue = 48 | pages = 30725–30 | date = November 1996 | pmid = 8940050 | doi = 10.1074/jbc.271.48.30725| doi-access = free }}
• PRKCE,{{cite journal | vauthors = England K, Ashford D, Kidd D, Rumsby M | title = PKC epsilon is associated with myosin IIA and actin in fibroblasts | journal = Cell. Signal. | volume = 14 | issue = 6 | pages = 529–36 | date = June 2002 | pmid = 11897493 | doi = 10.1016/s0898-6568(01)00277-7}} and
• RGS4.{{cite journal | vauthors = Sullivan BM, Harrison-Lavoie KJ, Marshansky V, Lin HY, Kehrl JH, Ausiello DA, Brown D, Druey KM | title = RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport | journal = Mol. Biol. Cell | volume = 11 | issue = 9 | pages = 3155–68 | date = September 2000 | pmid = 10982407 | pmc = 14982 | doi = 10.1091/mbc.11.9.3155}}

{{reflist}}

• {{UCSC gene info|COPB2}}
• {{PDBe-KB2|O55029|Mouse Coatomer subunit beta'}}

{{refbegin | 2}}

• {{cite journal | vauthors = Pelham HR, Rothman JE | title = The debate about transport in the Golgi--two sides of the same coin? | journal = Cell | volume = 102 | issue = 6 | pages = 713–9 | year = 2000 | pmid = 11030615 | doi = 10.1016/S0092-8674(00)00060-X | s2cid = 18044044 | doi-access = free }}
• {{cite journal | vauthors = Stenbeck G, Harter C, Brecht A, Herrmann D, Lottspeich F, Orci L, Wieland FT | title = beta'-COP, a novel subunit of coatomer | journal = EMBO J. | volume = 12 | issue = 7 | pages = 2841–5 | year = 1993 | pmid = 8334999 | pmc = 413534 | doi = 10.1002/j.1460-2075.1993.tb05945.x}}
• {{cite journal | vauthors = Harrison-Lavoie KJ, Lewis VA, Hynes GM, Collison KS, Nutland E, Willison KR | title = A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins | journal = EMBO J. | volume = 12 | issue = 7 | pages = 2847–53 | year = 1993 | pmid = 8335000 | pmc = 413536 | doi = 10.1002/j.1460-2075.1993.tb05946.x}}
• {{cite journal | vauthors = Lowe M, Kreis TE | title = In vitro assembly and disassembly of coatomer | journal = J. Biol. Chem. | volume = 270 | issue = 52 | pages = 31364–71 | year = 1996 | pmid = 8537409 | doi = 10.1074/jbc.270.52.31364 | doi-access = free }}
• {{cite journal | vauthors = Lowe M, Kreis TE | title = In vivo assembly of coatomer, the COP-I coat precursor | journal = J. Biol. Chem. | volume = 271 | issue = 48 | pages = 30725–30 | year = 1997 | pmid = 8940050 | doi = 10.1074/jbc.271.48.30725 | doi-access = free }}
• {{cite journal | vauthors = Csukai M, Chen CH, De Matteis MA, Mochly-Rosen D | title = The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon | journal = J. Biol. Chem. | volume = 272 | issue = 46 | pages = 29200–6 | year = 1997 | pmid = 9360998 | doi = 10.1074/jbc.272.46.29200 | doi-access = free }}
• {{cite journal | vauthors = Eugster A, Frigerio G, Dale M, Duden R | title = COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP | journal = EMBO J. | volume = 19 | issue = 15 | pages = 3905–17 | year = 2000 | pmid = 10921873 | pmc = 306616 | doi = 10.1093/emboj/19.15.3905 }}
• {{cite journal | vauthors = Sullivan BM, Harrison-Lavoie KJ, Marshansky V, Lin HY, Kehrl JH, Ausiello DA, Brown D, Druey KM | title = RGS4 and RGS2 Bind Coatomer and Inhibit COPI Association with Golgi Membranes and Intracellular Transport | journal = Mol. Biol. Cell | volume = 11 | issue = 9 | pages = 3155–68 | year = 2000 | pmid = 10982407 | pmc = 14982 | doi = 10.1091/mbc.11.9.3155 }}
• {{cite journal | vauthors = Zhang T, Hong W | title = Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport | journal = J. Biol. Chem. | volume = 276 | issue = 29 | pages = 27480–7 | year = 2001 | pmid = 11323436 | doi = 10.1074/jbc.M102786200 | doi-access = free }}
• {{cite journal | vauthors = Xu Y, Martin S, James DE, Hong W | title = GS15 Forms a SNARE Complex with Syntaxin 5, GS28, and Ykt6 and Is Implicated in Traffic in the Early Cisternae of the Golgi Apparatus | journal = Mol. Biol. Cell | volume = 13 | issue = 10 | pages = 3493–507 | year = 2003 | pmid = 12388752 | pmc = 129961 | doi = 10.1091/mbc.E02-01-0004 | url = http://espace.library.uq.edu.au/view/UQ:110331/UQ110331_OA.pdf }}
• {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2004 | pmid = 12665801 | doi = 10.1038/nbt810 | s2cid = 23783563 }}
• {{cite journal | vauthors = Rohde HM, Cheong FY, Konrad G, Paiha K, Mayinger P, Boehmelt G | title = The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex | journal = J. Biol. Chem. | volume = 278 | issue = 52 | pages = 52689–99 | year = 2004 | pmid = 14527956 | doi = 10.1074/jbc.M307983200 | doi-access = free }}
• {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 | s2cid = 11683986 }}
• {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
• {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
• {{cite journal | vauthors = Tu LC, Yan X, Hood L, Lin B | title = Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells | journal = Mol. Cell. Proteomics | volume = 6 | issue = 4 | pages = 575–88 | year = 2007 | pmid = 17220478 | doi = 10.1074/mcp.M600249-MCP200 | s2cid = 7203032 | doi-access = free}}

{{refend}}

{{Vesicular transport proteins}}

{{gene-3-stub}}