CORO1B

{{infobox protein

| Name = coronin, actin binding protein, 1B

| caption =

| image =

| width =

| HGNCid = 2253

| Symbol = CORO1B

| AltSymbols =

| EntrezGene = 57175

| OMIM = 609849

| RefSeq = NM_020441

| UniProt = Q9BR76

| PDB =

| ECnumber =

| Chromosome = 11

| Arm = q

| Band = 13.1

| LocusSupplementaryData =

}}

Coronin, actin binding protein, 1B also known as CORO1B is a protein which in humans is encoded by the CORO1B gene.{{cite journal | vauthors = Okumura M, Kung C, Wong S, Rodgers M, Thomas ML | title = Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein | journal = DNA Cell Biol. | volume = 17 | issue = 9 | pages = 779–87 |date=September 1998 | pmid = 9778037 | doi = 10.1089/dna.1998.17.779}} Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility.{{cite journal | vauthors = Cai L, Holoweckyj N, Schaller MD, Bear JE | title = Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility | journal = J. Biol. Chem. | volume = 280 | issue = 36 | pages = 31913–23 |date=September 2005 | pmid = 16027158 | doi = 10.1074/jbc.M504146200 | doi-access = free }}

Function

A mammalian coronin enriches at the leading edge of migrating cells.{{cite web | title = Entrez Gene: CORO1B coronin, actin binding protein, 1B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57175}} Studies related to this protein are as follows:

Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.{{cite journal | vauthors = Cai L, Makhov AM, Schafer DA, Bear JE | title = Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia | journal = Cell | volume = 134 | issue = 5 | pages = 828–42 |date=September 2008 | pmid = 18775315 | doi = 10.1016/j.cell.2008.06.054 | pmc = 2570342 }}
F-actin binding is essential for coronin 1B function in vivo.{{cite journal | vauthors = Cai L, Makhov AM, Bear JE | title = F-actin binding is essential for coronin 1B function in vivo | journal = J. Cell Sci. | volume = 120 | issue = Pt 10 | pages = 1779–90 |date=May 2007 | pmid = 17456547 | doi = 10.1242/jcs.007641 | doi-access = free }}
Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.{{cite journal | vauthors = Cai L, Marshall TW, Uetrecht AC, Schafer DA, Bear JE | title = Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge | journal = Cell | volume = 128 | issue = 5 | pages = 915–29 |date=March 2007 | pmid = 17350576 | pmc = 2630706 | doi = 10.1016/j.cell.2007.01.031 }}
Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury.{{cite journal | vauthors = Di Giovanni S, De Biase A, Yakovlev A, Finn T, Beers J, Hoffman EP, Faden AI | title = In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury | journal = J. Biol. Chem. | volume = 280 | issue = 3 | pages = 2084–91 |date=January 2005 | pmid = 15522871 | doi = 10.1074/jbc.M411975200 | doi-access = free }}
Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway.{{cite journal | vauthors = Parente JA, Chen X, Zhou C, Petropoulos AC, Chew CS | title = Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway | journal = J. Biol. Chem. | volume = 274 | issue = 5 | pages = 3017–25 |date=January 1999 | pmid = 9915840 | doi = 10.1074/jbc.274.5.3017| url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=9915840 | doi-access = free }}

CORO1B

Function

References