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CPA5

{{Short description|Protein-coding gene in humans}}

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Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene.{{cite journal | vauthors = Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD | title = Identification and characterization of three members of the human metallocarboxypeptidase gene family | journal = J Biol Chem | volume = 277 | issue = 17 | pages = 14954–64 |date=Apr 2002 | pmid = 11836249 | doi = 10.1074/jbc.M112254200 | doi-access = free }}{{cite web | title = Entrez Gene: CPA5 carboxypeptidase A5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93979}}

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002).[supplied by OMIM]

References

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External links

  • {{UCSC gene info|CPA5}}

Further reading

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  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Bentley L, Nakabayashi K, Monk D |title=The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome |journal=J. Med. Genet. |volume=40 |issue= 4 |pages= 249–56 |year= 2003 |pmid= 12676894 |doi=10.1136/jmg.40.4.249 | pmc=1735416 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Bonora E, Bacchelli E, Levy ER |title=Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region |journal=Mol. Psychiatry |volume=7 |issue= 3 |pages= 289–301 |year= 2002 |pmid= 11920156 |doi= 10.1038/sj.mp.4001004 |display-authors=etal|doi-access= |s2cid=13282515 }}
  • {{cite journal |title=A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium |journal=Hum. Mol. Genet. |volume=7 |issue= 3 |pages= 571–8 |year= 1998 |pmid= 9546821 |doi=10.1093/hmg/7.3.571 |doi-access=free |hdl=11858/00-001M-0000-0012-C9D8-C |hdl-access=free }}

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