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CPLX2

{{Short description|Protein-coding gene in humans}}

{{Infobox_gene}}

Complexin-2 is a protein that in humans is encoded by the CPLX2 gene.{{cite journal | vauthors = McMahon HT, Missler M, Li C, Sudhof TC | title = Complexins: cytosolic proteins that regulate SNAP receptor function | journal = Cell | volume = 83 | issue = 1 | pages = 111–9 |date=Nov 1995 | pmid = 7553862 | doi =10.1016/0092-8674(95)90239-2 | s2cid = 675343 | doi-access = free }}{{cite journal | vauthors = Raevskaya NM, Dergunova LV, Vladychenskaya IP, Stavchansky VV, Oborina MV, Poltaraus AB, Limborska SA | title = Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity | journal = Gene | volume = 359 | pages = 127–37 |date=Sep 2005 | pmid = 16162394 | doi = 10.1016/j.gene.2005.07.005 }}{{cite web | title = Entrez Gene: CPLX2 complexin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10814}}

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.

References

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External links

  • {{UCSC gene info|CPLX2}}

Further reading

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  • {{cite journal | author=Abe T |title=[The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 7 |pages= 794–800 |year= 2002 |pmid= 12058476 }}
  • {{cite journal | vauthors=Christensen VL, Johnston NP |title=Effect of time of day of insemination and the position of the egg in the oviduct on the fertility of turkeys |journal=Poult. Sci. |volume=56 |issue= 2 |pages= 458–62 |year= 1978 |pmid= 605033 |doi= 10.3382/ps.0560458|doi-access=free }}
  • {{cite journal | author=Morgans CW |title=A SNARE complex containing syntaxin 3 is present in ribbon synapses of the retina |journal=J. Neurosci. |volume=16 |issue= 21 |pages= 6713–21 |year= 1996 |pmid= 8824312 |doi= 10.1523/JNEUROSCI.16-21-06713.1996|name-list-style=vanc| author2=Brandstätter JH | author3=Kellerman J | display-authors=3 | last4=Betz | first4=H | last5=Wässle | first5=H |pmc=6579260 |doi-access=free}}
  • {{cite journal | vauthors=Harrison PJ, Eastwood SL |title=Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia |journal=Lancet |volume=352 |issue= 9141 |pages= 1669–73 |year= 1998 |pmid= 9853440 |doi=10.1016/S0140-6736(98)03341-8 |s2cid=45239545 }}
  • {{cite journal | author=Ishizuka T |title=Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex |journal=Neuroscience |volume=88 |issue= 1 |pages= 295–306 |year= 1999 |pmid= 10051208 |doi=10.1016/S0306-4522(98)00223-1 |name-list-style=vanc| author2=Saisu H | author3=Odani S | display-authors=3 | last4=Kumanishi | first4=T | last5=Abe | first5=T |s2cid=46636775 }}
  • {{cite journal | author=Yamada M |title=Immunohistochemical distribution of the two isoforms of synaphin/complexin involved in neurotransmitter release: localization at the distinct central nervous system regions and synaptic types |journal=Neuroscience |volume=93 |issue= 1 |pages= 7–18 |year= 1999 |pmid= 10430466 |doi=10.1016/S0306-4522(99)00104-9 |name-list-style=vanc| author2=Saisu H | author3=Ishizuka T | display-authors=3 | last4=Takahashi | first4=H | last5=Abe | first5=T |s2cid=21532356 }}
  • {{cite journal | author=Pabst S |title=Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19808–18 |year= 2000 |pmid= 10777504 |doi= 10.1074/jbc.M002571200 |name-list-style=vanc| author2=Hazzard JW | author3=Antonin W | display-authors=3 | last4=Südhof | first4=TC | last5=Jahn | first5=R | last6=Rizo | first6=J | last7=Fasshauer | first7=D | doi-access=free }}
  • {{cite journal | vauthors=Eastwood SL, Cotter D, Harrison PJ |title=Cerebellar synaptic protein expression in schizophrenia |journal=Neuroscience |volume=105 |issue= 1 |pages= 219–29 |year= 2001 |pmid= 11483314 |doi=10.1016/S0306-4522(01)00141-5 |s2cid=34257327 }}
  • {{cite journal | vauthors=Eastwood SL, Harrison PJ |title=Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins |journal=Brain Res. Bull. |volume=55 |issue= 5 |pages= 569–78 |year= 2001 |pmid= 11576753 |doi=10.1016/S0361-9230(01)00530-5 |s2cid=23012653 }}
  • {{cite journal | author=Pabst S |title=Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7838–48 |year= 2002 |pmid= 11751907 |doi= 10.1074/jbc.M109507200 |name-list-style=vanc| author2=Margittai M | author3=Vainius D | display-authors=3 | last4=Langen | first4=R | last5=Jahn | first5=R | last6=Fasshauer | first6=D | doi-access=free| hdl=11858/00-001M-0000-0012-F415-9| hdl-access=free}}
  • {{cite journal | author=Sawada K |title=Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness |journal=Mol. Psychiatry |volume=7 |issue= 5 |pages= 484–92 |year= 2002 |pmid= 12082566 |doi= 10.1038/sj.mp.4000978 |name-list-style=vanc| author2=Young CE | author3=Barr AM | display-authors=3 | last4=Longworth | first4=K | last5=Takahashi | first5=S | last6=Arango | first6=V | last7=Mann | first7=J J | last8=Dwork | first8=A J | last9=Falkai | first9=P | doi-access=free }}
  • {{cite journal | vauthors=Hu K, Carroll J, Rickman C, Davletov B |title=Action of complexin on SNARE complex |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 41652–6 |year= 2003 |pmid= 12200427 |doi= 10.1074/jbc.M205044200 |doi-access= free }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Edwardson JM |title=Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 30849–53 |year= 2003 |pmid= 12807877 |doi= 10.1074/jbc.M304615200 |name-list-style=vanc| author2=Wang CT | author3=Gong B | display-authors=3 | last4=Wyttenbach | first4=A | last5=Bai | first5=J | last6=Jackson | first6=MB | last7=Chapman | first7=ER | last8=Morton | first8=AJ | doi-access=free }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | vauthors=Eastwood SL, Harrison PJ |title=Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons |journal=Schizophr. Res. |volume=73 |issue= 2–3 |pages= 159–72 |year= 2005 |pmid= 15653259 |doi= 10.1016/j.schres.2004.05.010 |s2cid=2335413 }}
  • {{cite journal | author=DiProspero NA |title=Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements |journal=J. Neurocytol. |volume=33 |issue= 5 |pages= 517–33 |year= 2005 |pmid= 15906159 |doi= 10.1007/s11068-004-0514-8 |name-list-style=vanc| author2=Chen EY | author3=Charles V | display-authors=3 | last4=Plomann | first4=Markus | last5=Kordower | first5=Jeffrey H. | last6=Tagle | first6=Danilo A. |s2cid=20082165 |url=https://zenodo.org/record/1232828 }}

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