CPNE8
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Copine-8 is a protein that in humans is encoded by the CPNE8 gene.{{cite journal | vauthors = Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B | title = Cloning, molecular characterization, and expression analysis of Copine 8 | journal = Biochem Biophys Res Commun | volume = 303 | issue = 3 | pages = 842–847 |date=Apr 2003 | pmid = 12670487 | doi =10.1016/S0006-291X(03)00445-5 | url = https://zenodo.org/record/1259535 }}{{cite web | title = Entrez Gene: CPNE8 copine VIII| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=144402}}
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus.
References
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Further reading
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- {{cite journal | author=Creutz CE |title=The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1393–1402 |year= 1998 |pmid= 9430674 |doi=10.1074/jbc.273.3.1393 |name-list-style=vanc| author2=Tomsig JL | author3=Snyder SL | display-authors=3 | last4=Gautier | first4=MC | last5=Skouri | first5=F | last6=Beisson | first6=J | last7=Cohen | first7=J | doi-access=free }}
- {{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–1795 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
- {{cite journal | vauthors=Tomsig JL, Creutz CE |title=Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein |journal=Biochemistry |volume=39 |issue= 51 |pages= 16163–16175 |year= 2001 |pmid= 11123945 |doi=10.1021/bi0019949 }}
- {{cite journal | author=Wiemann S |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–435 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |name-list-style=vanc| author2=Weil B | author3=Wellenreuther R | display-authors=3 | last4=Gassenhuber | first4=J | last5=Glassl | first5=S | last6=Ansorge | first6=W | last7=Böcher | first7=M | last8=Blöcker | first8=H | last9=Bauersachs | first9=S }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Ramsey H |title=Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation |journal=Leukemia |volume=17 |issue= 8 |pages= 1665–1666 |year= 2003 |pmid= 12886257 |doi= 10.1038/sj.leu.2403048 |name-list-style=vanc| author2=Zhang DE | author3=Richkind K | display-authors=3 | last4=Burcoglu-o'Ral | first4=A | last5=Hromas | first5=R |doi-access=free }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Wiemann S |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–2144 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |name-list-style=vanc| author2=Arlt D | author3=Huber W | display-authors=3 | last4=Wellenreuther | first4=R | last5=Schleeger | first5=S | last6=Mehrle | first6=A | last7=Bechtel | first7=S | last8=Sauermann | first8=M | last9=Korf | first9=U }}
- {{cite journal | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–D418 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |name-list-style=vanc| author2=Rosenfelder H | author3=Schupp I | display-authors=3 | last4=Del Val | first4=C | last5=Arlt | first5=D | last6=Hahne | first6=F | last7=Bechtel | first7=S | last8=Simpson | first8=J | last9=Hofmann | first9=O }}
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External links
- {{UCSC gene info|CPNE8}}
{{gene-12-stub}}