CRADD

The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.

CRADD has been shown to interact with RIPK1 and Caspase 2.{{cite journal | vauthors = Tinel A, Tschopp J | title = The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress | journal = Science | volume = 304 | issue = 5672 | pages = 843–6 | date = May 2004 | pmid = 15073321 | doi = 10.1126/science.1095432 | bibcode = 2004Sci...304..843T | s2cid = 6583298 }}{{cite journal | vauthors = Droin N, Beauchemin M, Solary E, Bertrand R | title = Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade | journal = Cancer Res. | volume = 60 | issue = 24 | pages = 7039–47 | date = December 2000 | pmid = 11156409 }}

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• {{UCSC gene info|CRADD}}

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• {{cite journal | vauthors = Lennon G, Auffray C, Polymeropoulos M, Soares MB | title = The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression | journal = Genomics | volume = 33 | issue = 1 | pages = 151–2 | year = 1996 | pmid = 8617505 | doi = 10.1006/geno.1996.0177 | doi-access = free }}
• {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Res. | volume = 6 | issue = 9 | pages = 807–28 | year = 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 | doi-access = free }}
• {{cite journal | vauthors = Chou JJ, Matsuo H, Duan H, Wagner G | title = Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment | journal = Cell | volume = 94 | issue = 2 | pages = 171–80 | year = 1998 | pmid = 9695946 | doi = 10.1016/S0092-8674(00)81417-8 | s2cid = 16499945 | doi-access = free }}
• {{cite journal | vauthors = Horvat S, Medrano JF | title = A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region | journal = Genomics | volume = 54 | issue = 1 | pages = 159–64 | year = 1998 | pmid = 9806843 | doi = 10.1006/geno.1998.5540 }}
• {{cite journal | vauthors = Shearwin-Whyatt LM, Harvey NL, Kumar S | title = Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD | journal = Cell Death Differ. | volume = 7 | issue = 2 | pages = 155–65 | year = 2000 | pmid = 10713730 | doi = 10.1038/sj.cdd.4400632 | doi-access = free }}
• {{cite journal | vauthors = Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, Hood L | title = Activation of the NF-kappaB pathway by caspase 8 and its homologs | journal = Oncogene | volume = 19 | issue = 39 | pages = 4451–60 | year = 2000 | pmid = 11002417 | doi = 10.1038/sj.onc.1203812 | doi-access = free }}
• {{cite journal | vauthors = Droin N, Beauchemin M, Solary E, Bertrand R | title = Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade | journal = Cancer Res. | volume = 60 | issue = 24 | pages = 7039–47 | year = 2000 | pmid = 11156409 }}
• {{cite journal | vauthors = Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES | title = Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria | journal = J. Biol. Chem. | volume = 277 | issue = 16 | pages = 13430–7 | year = 2002 | pmid = 11832478 | doi = 10.1074/jbc.M108029200 | doi-access = free }}
• {{cite journal | vauthors = Tinel A, Tschopp J | title = The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress | journal = Science | volume = 304 | issue = 5672 | pages = 843–6 | year = 2004 | pmid = 15073321 | doi = 10.1126/science.1095432 | bibcode = 2004Sci...304..843T | s2cid = 6583298 }}
• {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
• {{cite journal | vauthors = Park HH, Wu H | title = Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly | journal = J. Mol. Biol. | volume = 357 | issue = 2 | pages = 358–64 | year = 2006 | pmid = 16434054 | pmc = 2902980 | doi = 10.1016/j.jmb.2005.12.082 }}
• {{cite journal | vauthors = Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B | title = Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage | journal = Oncogene | volume = 25 | issue = 41 | pages = 5683–92 | year = 2006 | pmid = 16652156 | doi = 10.1038/sj.onc.1209569 | doi-access = free }}
• {{cite journal | vauthors = Park HH, Wu H | title = Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD | journal = Acta Crystallographica Section F | volume = 63 | issue = Pt 3 | pages = 229–32 | year = 2007 | pmid = 17329820 | pmc = 2330181 | doi = 10.1107/S1744309107007889 }}

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