CRL

• Chalk River Laboratories, a Canadian nuclear research center
• Charles River Laboratories, an American biomedical company
• Computational Research Laboratories, an Indian computer company
• CRL infrared sky survey

• Canada Rugby League, the governing body for rugby league football in Canada
• Championship Racing League, a co-sanctioning arrangement between CART and USAC for the 1980 CART PPG Indy Car World Series
• Country Rugby League, governing body for rugby league football in rural New South Wales, Australia

• Canons Regular of the Lateran, a Catholic religious order
• Center for Research Libraries, a consortium of North American universities, colleges, and independent research libraries
• Co-operative Retail Logistics, part of the Co-operative Group
• Corsair International, formerly Corsairfly (ICAO airline designator)
• CRL Group, a British video game company

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• Certificate revocation list, in computing, a list of revoked certificates
• Chemistry Research Laboratory, University of Oxford, the main chemistry building at Oxford University
• Complete Response Letter, the official FDA response to a New Drug Application
• Crown-rump length, the ultrasound measurement of a foetus

• Brussels South Charleroi Airport (IATA code CRL)
• Chicago Rail Link, a shortline railroad in Chicago
• City Rail Link, an under-construction rail project in Auckland, New Zealand
• Cross Island MRT line, a planned mass transit line for Singapore

• East Cree language (ISO 639-3 code crl)
• Certified Registered Locksmith, as awarded by the Associated Locksmiths of America

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