CRYBB3

{{Short description|Protein-coding gene in the species Homo sapiens}}

Beta-crystallin B3 is a protein that in humans is encoded by the CRYBB3 gene.{{cite journal | vauthors = Lampi KJ, Ma Z, Shih M, Shearer TR, Smith JB, Smith DL, David LL | title = Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens | journal = J Biol Chem | volume = 272 | issue = 4 | pages = 2268–75 |date=Feb 1997 | pmid = 8999933 | doi =10.1074/jbc.272.4.2268 | doi-access = free }}{{cite web | title = Entrez Gene: CRYBB3 crystallin, beta B3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1417}}

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins.

Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions.

Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2.

References

External links

{{UCSC gene info|CRYBB3}}

{{cite journal | author=Aarts HJ |title=Different evolution rates within the lens-specific beta-crystallin gene family |journal=J. Mol. Evol. |volume=28 |issue= 4 |pages= 313–21 |year= 1989 |pmid= 2499686 |doi=10.1007/BF02103427 |name-list-style=vanc| author2=Jacobs EH | author3=van Willigen G | display-authors=3 | last4=Lubsen | first4=Nicolette H. | last5=Schoenmakers | first5=John G. G. |bibcode=1989JMolE..28..313A |s2cid=40148208 }}
{{cite journal | author=Kramer P |title=A second gene for cerulean cataracts maps to the beta crystallin region on chromosome 22 |journal=Genomics |volume=35 |issue= 3 |pages= 539–42 |year= 1996 |pmid= 8812489 |doi= 10.1006/geno.1996.0395 |name-list-style=vanc| author2=Yount J | author3=Mitchell T | display-authors=3 | last4=Lamorticella | first4=Dante | last5=Carrero-Valenzuela | first5=Roque | last6=Lovrien | first6=Everett | last7=Maumenee | first7=Irene | last8=Litt | first8=Michael | doi-access=free }}
{{cite journal | author=Kimoto Y |title=A possibility of all mRNA expression in a human single lymphocyte |journal=Hum. Cell |volume=9 |issue= 4 |pages= 367–70 |year= 1997 |pmid= 9183670 }}
{{cite journal | author=Dunham I |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |name-list-style=vanc| author2=Shimizu N | author3=Roe BA | display-authors=3 | last4=Bruskiewich | first4=R. | last5=Beare | first5=D. M. | last6=Clamp | first6=M. | last7=Smink | first7=L. J. | last8=Ainscough | first8=R. | last9=Almeida | first9=J. P. |bibcode=1999Natur.402..489D | doi-access=free }}
{{cite journal | author=MacCoss MJ |title=Shotgun identification of protein modifications from protein complexes and lens tissue |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 7900–5 |year= 2002 |pmid= 12060738 |doi= 10.1073/pnas.122231399 | pmc=122992 |name-list-style=vanc| author2=McDonald WH | author3=Saraf A | display-authors=3 | last4=Sadygov | first4=R | last5=Clark | first5=JM | last6=Tasto | first6=JJ | last7=Gould | first7=KL | last8=Wolters | first8=D | last9=Washburn | first9=M |bibcode=2002PNAS...99.7900M |doi-access=free }}
{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal | author=Collins JE |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |name-list-style=vanc| author2=Wright CL | author3=Edwards CA | display-authors=3 | last4=Davis | first4=Matthew P | last5=Grinham | first5=James A | last6=Cole | first6=Charlotte G | last7=Goward | first7=Melanie E | last8=Aguado | first8=Begoña | last9=Mallya | first9=Meera |doi-access=free }}
{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
{{cite journal | author=Riazuddin SA |title=Mutations in betaB3-crystallin associated with autosomal recessive cataract in two Pakistani families |journal=Invest. Ophthalmol. Vis. Sci. |volume=46 |issue= 6 |pages= 2100–6 |year= 2005 |pmid= 15914629 |doi= 10.1167/iovs.04-1481 |name-list-style=vanc| author2=Yasmeen A | author3=Yao W | display-authors=3 | last4=Sergeev | first4=YV | last5=Zhang | first5=Q | last6=Zulfiqar | first6=F | last7=Riaz | first7=A | last8=Riazuddin | first8=S | last9=Hejtmancik | first9=JF | doi-access= }}

CRYBB3

References

External links

Further reading