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CRYZ

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Quinone oxidoreductase is an enzyme that in humans is encoded by the CRYZ gene.{{cite web | title = Entrez Gene: CRYZ crystallin, zeta (quinone reductase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1429}}

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. One pseudogene is known to exist.

References

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External links

  • {{UCSC gene info|CRYZ}}

Further reading

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  • {{cite journal | vauthors=Heinzmann C, Kojis TL, Gonzalez P |title=Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms |journal=Genomics |volume=23 |issue= 2 |pages= 403–7 |year= 1995 |pmid= 7835889 |doi= 10.1006/geno.1994.1516 |display-authors=etal}}
  • {{cite journal | vauthors=Gonzalez P, Rao PV, Zigler JS |title=Organization of the human zeta-crystallin/quinone reductase gene (CRYZ) |journal=Genomics |volume=21 |issue= 2 |pages= 317–24 |year= 1994 |pmid= 8088825 |doi= 10.1006/geno.1994.1272 |url=https://zenodo.org/record/1229634 }}
  • {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors=Gonzalez P, Rao PV, Zigler JS |title=Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver |journal=Biochem. Biophys. Res. Commun. |volume=191 |issue= 3 |pages= 902–7 |year= 1993 |pmid= 8466529 |doi= 10.1006/bbrc.1993.1302 |url= https://zenodo.org/record/1229410 }}
  • {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
  • {{cite journal | vauthors=Wang W, Liu LQ, Higuchi CM, Chen H |title=Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells |journal=Biochem. Pharmacol. |volume=56 |issue= 2 |pages= 189–95 |year= 1998 |pmid= 9698072 |doi=10.1016/S0006-2952(98)00141-5 }}
  • {{cite journal | vauthors=Goenka S, Raman B, Ramakrishna T, Rao CM |title=Unfolding and refolding of a quinone oxidoreductase: alpha-crystallin, a molecular chaperone, assists its reactivation |journal=Biochem. J. |volume=359 |issue= Pt 3 |pages= 547–56 |year= 2001 |pmid= 11672428 |doi=10.1042/0264-6021:3590547 | pmc=1222175 }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Bianco NR, Perry G, Smith MA |title=Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage |journal=Mol. Endocrinol. |volume=17 |issue= 7 |pages= 1344–55 |year= 2004 |pmid= 12714703 |doi= 10.1210/me.2002-0382 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}

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{{PDB Gallery|geneid=1429}}

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