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CSTF1

{{Short description|Protein-coding gene in humans}}

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{{Infobox_gene}}

Cleavage stimulation factor 50 kDa subunit is a protein that in humans is encoded by the CSTF1 gene.{{cite journal | vauthors = Takagaki Y, Manley JL | title = A human polyadenylation factor is a G protein beta-subunit homologue | journal = The Journal of Biological Chemistry | volume = 267 | issue = 33 | pages = 23471–4 | date = November 1992 | doi = 10.1016/S0021-9258(18)35861-7 | pmid = 1358884 | doi-access = free }}{{cite journal | vauthors = Kleiman FE, Manley JL | title = The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression | journal = Cell | volume = 104 | issue = 5 | pages = 743–53 | date = March 2001 | pmid = 11257228 | doi = 10.1016/S0092-8674(01)00270-7 | s2cid = 15022237 | doi-access = free }}

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.{{cite web | title = Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1477}}

Interactions

CSTF1 has been shown to interact with BARD1.{{cite journal | vauthors = Kleiman FE, Manley JL | title = Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 | journal = Science | volume = 285 | issue = 5433 | pages = 1576–9 | date = September 1999 | pmid = 10477523 | doi = 10.1126/science.285.5433.1576 }}

References

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External links

  • {{UCSC gene info|CSTF1}}

Further reading

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  • {{cite journal | vauthors = Takagaki Y, MacDonald CC, Shenk T, Manley JL | title = The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 4 | pages = 1403–7 | date = February 1992 | pmid = 1741396 | pmc = 48459 | doi = 10.1073/pnas.89.4.1403 | bibcode = 1992PNAS...89.1403T | doi-access = free }}
  • {{cite journal | vauthors = Murthy KG, Manley JL | title = The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation | journal = Genes & Development | volume = 9 | issue = 21 | pages = 2672–83 | date = November 1995 | pmid = 7590244 | doi = 10.1101/gad.9.21.2672 | doi-access = free }}
  • {{cite journal | vauthors = Takagaki Y, Manley JL | title = A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein | journal = Nature | volume = 372 | issue = 6505 | pages = 471–4 | date = December 1994 | pmid = 7984242 | doi = 10.1038/372471a0 | bibcode = 1994Natur.372..471T | s2cid = 4329672 }}
  • {{cite journal | vauthors = Rüegsegger U, Beyer K, Keller W | title = Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors | journal = The Journal of Biological Chemistry | volume = 271 | issue = 11 | pages = 6107–13 | date = March 1996 | pmid = 8626397 | doi = 10.1074/jbc.271.11.6107 | doi-access = free }}
  • {{cite journal | vauthors = Kleiman FE, Manley JL | title = Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 | journal = Science | volume = 285 | issue = 5433 | pages = 1576–9 | date = September 1999 | pmid = 10477523 | doi = 10.1126/science.285.5433.1576 }}
  • {{cite journal | vauthors = Takagaki Y, Manley JL | title = Complex protein interactions within the human polyadenylation machinery identify a novel component | journal = Molecular and Cellular Biology | volume = 20 | issue = 5 | pages = 1515–25 | date = March 2000 | pmid = 10669729 | pmc = 85326 | doi = 10.1128/MCB.20.5.1515-1525.2000 }}
  • {{cite journal | vauthors = Fong N, Bentley DL | title = Capping, splicing, and 3' processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD | journal = Genes & Development | volume = 15 | issue = 14 | pages = 1783–95 | date = July 2001 | pmid = 11459828 | pmc = 312735 | doi = 10.1101/gad.889101 }}
  • {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = January 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 | s2cid = 14132033 | doi-access = free | bibcode = 2002CBio...12....1A }}
  • {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = January 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }}
  • {{cite journal | vauthors = Tsuzuki M, Wu W, Nishikawa H, Hayami R, Oyake D, Yabuki Y, Fukuda M, Ohta T | title = A truncated splice variant of human BARD1 that lacks the RING finger and ankyrin repeats | journal = Cancer Letters | volume = 233 | issue = 1 | pages = 108–16 | date = February 2006 | pmid = 15878232 | doi = 10.1016/j.canlet.2005.03.012 }}

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