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CTDSPL

{{Short description|Protein-coding gene in the species Homo sapiens}}

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CTD small phosphatase-like protein is an enzyme that in humans is encoded by the CTDSPL gene.{{cite journal | vauthors = Ishikawa S, Kai M, Tamari M, Takei Y, Takeuchi K, Bandou H, Yamane Y, Ogawa M, Nakamura Y | title = Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line | journal = DNA Res | volume = 4 | issue = 1 | pages = 35–43 |date=Aug 1997 | pmid = 9179494 | doi =10.1093/dnares/4.1.35 | doi-access = free }}{{cite journal | vauthors = Protopopov A, Kashuba V, Zabarovska VI, Muravenko OV, Lerman MI, Klein G, Zabarovsky ER | title = An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies | journal = Cancer Res | volume = 63 | issue = 2 | pages = 404–12 |date=Jan 2003 | pmid = 12543795 }}{{cite web | title = Entrez Gene: CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10217}}

Interactions

CTDSPL has been shown to interact with SNAI1.{{cite journal |last=Wu |first=Yadi |author2=Evers B Mark |author3=Zhou Binhua P |date=Jan 2009 |title=Small C-terminal domain phosphatase enhances snail activity through dephosphorylation |journal=J. Biol. Chem. |volume=284 |issue=1 |pages=640–8 |location = United States| issn = 0021-9258| pmid = 19004823 |doi = 10.1074/jbc.M806916200 |pmc=2610500 |doi-access=free }}

References

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Further reading

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  • {{cite journal | vauthors=O'Keeffe B, Fong Y, Chen D |title=Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 279–87 |year= 2000 |pmid= 10617616 |doi=10.1074/jbc.275.1.279 |display-authors=etal|doi-access= free}}
  • {{cite journal | vauthors=Kim JB, Sharp PA |title=Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 12317–23 |year= 2001 |pmid= 11145967 |doi= 10.1074/jbc.M010908200 |doi-access= free }}
  • {{cite journal | vauthors=Ramanathan Y, Rajpara SM, Reza SM |title=Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences. |journal=J. Biol. Chem. |volume=276 |issue= 14 |pages= 10913–20 |year= 2001 |pmid= 11278802 |doi= 10.1074/jbc.M010975200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Zhou M, Nekhai S, Bharucha DC |title=TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44633–40 |year= 2002 |pmid= 11572868 |doi= 10.1074/jbc.M107466200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Lin X, Taube R, Fujinaga K, Peterlin BM |title=P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16873–8 |year= 2002 |pmid= 11884399 |doi= 10.1074/jbc.M200117200 |doi-access=free }}
  • {{cite journal | vauthors=Kim YK, Bourgeois CF, Isel C |title=Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4622–37 |year= 2002 |pmid= 12052871 |doi=10.1128/MCB.22.13.4622-4637.2002 | pmc=133925 |display-authors=etal}}
  • {{cite journal | vauthors=Yeo M, Lin PS, Dahmus ME, Gill GN |title=A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 26078–85 |year= 2003 |pmid= 12721286 |doi= 10.1074/jbc.M301791200 |doi-access= free }}
  • {{cite journal | vauthors=Pinhero R, Liaw P, Bertens K, Yankulov K |title=Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II. |journal=Eur. J. Biochem. |volume=271 |issue= 5 |pages= 1004–14 |year= 2004 |pmid= 15009212 |doi=10.1111/j.1432-1033.2004.04002.x |doi-access=free }}
  • {{cite journal | vauthors=Kashuba VI, Li J, Wang F |title=RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 14 |pages= 4906–11 |year= 2004 |pmid= 15051889 |doi= 10.1073/pnas.0401238101 | pmc=387347 |display-authors=etal|bibcode=2004PNAS..101.4906K |doi-access=free }}

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External links

  • {{UCSC genome browser|CTDSPL}}
  • {{UCSC gene details|CTDSPL}}

{{PDB Gallery|geneid=10217}}

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