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CTTNBP2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox_gene}}

Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene.{{cite journal | vauthors = Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW | title = Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31 | journal = Genomics | volume = 78 | issue = 1–2 | pages = 7–11 | date = Nov 2001 | pmid = 11707066 | doi = 10.1006/geno.2001.6651 }}{{cite web | title = Entrez Gene: CTTNBP2 cortactin binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83992}}

Function

This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.

Interactions

CTTNBP2 has been shown to interact with:

  • MOBKL3,
  • PPP2CA,
  • RP6-213H19.1,{{cite journal | vauthors = Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC | title = A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein | journal = Mol. Cell. Proteomics | volume = 8 | issue = 1 | pages = 157–71 | date = Jan 2009 | pmid = 18782753 | pmc = 2621004 | doi = 10.1074/mcp.M800266-MCP200 | doi-access = free }}
  • STRN3, and
  • STRN.

References

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External links

  • {{UCSC gene info|CTTNBP2}}

Further reading

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  • {{cite journal | vauthors = Ohoka Y, Takai Y | title = Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90 | journal = Genes Cells | volume = 3 | issue = 9 | pages = 603–12 | year = 1998 | pmid = 9813110 | doi = 10.1046/j.1365-2443.1998.00216.x | s2cid = 22413036 | doi-access = free }}
  • {{cite journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 6 | pages = 347–55 | year = 2000 | pmid = 11214970 | doi = 10.1093/dnares/7.6.347 | doi-access = free }}
  • {{cite journal | vauthors = Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C, Alt F, Luther K, Braz C, Sadoni N, Rosenecker J, Schindelhauer D | title = Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei | journal = J. Cell Biol. | volume = 166 | issue = 6 | pages = 815–25 | year = 2004 | pmid = 15364959 | pmc = 2172106 | doi = 10.1083/jcb.200404107 }}

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