CXCL13
{{Short description|Mammalian protein found in Homo sapiens}}
{{Infobox_gene}}
Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene.{{cite journal | vauthors = Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B | title = B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5 | journal = J. Exp. Med. | volume = 187 | issue = 4 | pages = 655–60 |date=February 1998 | pmid = 9463416 | pmc = 2212150 | doi = 10.1084/jem.187.4.655}}{{cite journal | vauthors = Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT | title = A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1 | journal = Nature | volume = 391 | issue = 6669 | pages = 799–803 |date=February 1998 | pmid = 9486651 | doi = 10.1038/35876 | bibcode = 1998Natur.391..799G | s2cid = 4373691 }}
Function
CXCL13 is a small chemokine belonging to the CXC chemokine family. As its other names suggest, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5.{{cite journal | vauthors = Ansel KM, Harris RB, Cyster JG | title = CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity | journal = Immunity | volume = 16 | issue = 1 | pages = 67–76 |date=January 2002 | pmid = 11825566 | doi = 10.1016/S1074-7613(01)00257-6| doi-access = free }} CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues{{cite journal | vauthors = Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG | title = A chemokine-driven positive feedback loop organizes lymphoid follicles | journal = Nature | volume = 406 | issue = 6793 | pages = 309–14 |date=July 2000 | pmid = 10917533 | doi = 10.1038/35018581 | s2cid = 4369622 }} and is expressed highly in the liver, spleen, lymph nodes, and gut of humans. The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines.
In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or TFH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as angioimmunoblastic T-cell lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.{{cite journal | vauthors = de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P | title = The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells | journal = Blood | volume = 109 | issue = 11 | pages = 4952–63 |date=June 2007 | pmid = 17284527 | doi = 10.1182/blood-2006-10-055145 | doi-access = free }}
References
{{Reflist}}
External links
- {{UCSC gene info|CXCL13}}
- {{PDBe-KB2|O43927|C-X-C motif chemokine 13}}
{{Chemokines}}
{{Chemokine receptor modulators}}
{{gene-4-stub}}