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CXCL7

{{Short description|Mammalian protein found in Homo sapiens}}

{{cs1 config|name-list-style=vanc}}

{{Infobox_gene}}

Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene.{{cite web | title = Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5473}}

The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP).{{cite journal |vauthors=Hristov M, Zernecke A, Bidzhekov K |title=Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury |journal=Circ. Res. |volume=100 |issue=4 |pages=590–7 |date=March 2007 |pmid=17272812 |doi=10.1161/01.RES.0000259043.42571.68 |display-authors=etal|doi-access=free }}

It is a protein that is released in large amounts from platelets following their activation.{{cite journal |vauthors=Majumdar S, Gonder D, Koutsis B, Poncz M |title=Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4 |journal=J Biol Chem |volume=266 |issue=9 |pages=5785–9 |year=1991 |doi=10.1016/S0021-9258(19)67665-9 |pmid=1826003|doi-access=free }} It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.{{cite journal |vauthors=Castor C, Miller J, Walz D |title=Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor |journal=Proc Natl Acad Sci USA |volume=80 |issue=3 |pages=765–9 |year=1983 |pmid=6572368 |doi=10.1073/pnas.80.3.765 |pmc=393460|bibcode=1983PNAS...80..765C |doi-access=free }}{{cite journal |vauthors=Castor C, Furlong A, Carter-Su C |title=Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III |journal=Biochemistry |volume=24 |issue=7 |pages=1762–7 |year=1985 |pmid=4005226 |doi=10.1021/bi00328a029}}

References

{{Reflist}}

Further reading

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  • {{cite journal | vauthors=Begg GS, Pepper DS, Chesterman CN, Morgan FJ |title=Complete covalent structure of human beta-thromboglobulin. |journal=Biochemistry |volume=17 |issue= 9 |pages= 1739–44 |year= 1978 |pmid= 77677 |doi=10.1021/bi00602a024 }}
  • {{cite journal | vauthors=Kaplan KL, Broekman MJ, Chernoff A |title=Platelet alpha-granule proteins: studies on release and subcellular localization. |journal=Blood |volume=53 |issue= 4 |pages= 604–18 |year= 1979 |pmid= 426909 |doi= 10.1182/blood.V53.4.604.604|display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Tunnacliffe A, Majumdar S, Yan B, Poncz M |title=Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4. |journal=Blood |volume=79 |issue= 11 |pages= 2896–900 |year= 1992 |pmid= 1316786 |doi= 10.1182/blood.V79.11.2896.2896 |doi-access=free }}
  • {{cite journal | vauthors=Cohen AB, Stevens MD, Miller EJ |title=Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets. |journal=Am. J. Physiol. |volume=263 |issue= 2 Pt 1 |pages= L249–56 |year= 1992 |pmid= 1387511 |doi= 10.1152/ajplung.1992.263.2.L249|display-authors=etal}}
  • {{cite journal | vauthors=Morris SW, Nelson N, Valentine MB |title=Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. |journal=Genomics |volume=14 |issue= 3 |pages= 685–91 |year= 1992 |pmid= 1427896 |doi=10.1016/S0888-7543(05)80169-7 |display-authors=etal}}
  • {{cite journal | vauthors=Majumdar S, Gonder D, Koutsis B, Poncz M |title=Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. |journal=J. Biol. Chem. |volume=266 |issue= 9 |pages= 5785–9 |year= 1991 |doi=10.1016/S0021-9258(19)67665-9 |pmid= 1826003 |doi-access=free }}
  • {{cite journal | vauthors=Wenger RH, Hameister H, Clemetson KJ |title=Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily. |journal=Hum. Genet. |volume=87 |issue= 3 |pages= 367–8 |year= 1991 |pmid= 1830861 |doi=10.1007/BF00200921 |s2cid=19420329 }}
  • {{cite journal | vauthors=Hjemdahl P, Perneby C, Theodorsson E |title=A new assay for beta-thromboglobulin in urine. |journal=Thromb. Res. |volume=64 |issue= 1 |pages= 33–43 |year= 1992 |pmid= 1837963 |doi=10.1016/0049-3848(91)90203-9 |display-authors=etal}}
  • {{cite journal | vauthors=Brandt E, Van Damme J, Flad HD |title=Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived connective tissue-activating peptide III. |journal=Cytokine |volume=3 |issue= 4 |pages= 311–21 |year= 1991 |pmid= 1873479 |doi=10.1016/1043-4666(91)90499-4 }}
  • {{cite journal | vauthors=Clark-Lewis I, Moser B, Walz A |title=Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide. |journal=Biochemistry |volume=30 |issue= 12 |pages= 3128–35 |year= 1991 |pmid= 2007144 |doi=10.1021/bi00226a021 |display-authors=etal}}
  • {{cite journal | vauthors=Walz A, Baggiolini M |title=Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. |journal=J. Exp. Med. |volume=171 |issue= 2 |pages= 449–54 |year= 1990 |pmid= 2406364 |doi=10.1084/jem.171.2.449 | pmc=2187709 }}
  • {{cite journal | vauthors=Holt JC, Harris ME, Holt AM |title=Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin. |journal=Biochemistry |volume=25 |issue= 8 |pages= 1988–96 |year= 1986 |pmid= 2423119 |doi=10.1021/bi00356a023 |display-authors=etal}}
  • {{cite journal | vauthors=Walz A, Baggiolini M |title=A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils. |journal=Biochem. Biophys. Res. Commun. |volume=159 |issue= 3 |pages= 969–75 |year= 1989 |pmid= 2522778 |doi=10.1016/0006-291X(89)92203-1 }}
  • {{cite journal | vauthors=Wenger RH, Wicki AN, Walz A |title=Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library. |journal=Blood |volume=73 |issue= 6 |pages= 1498–503 |year= 1989 |pmid= 2713489 |doi= 10.1182/blood.V73.6.1498.1498|display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Castor CW, Walz DA, Ragsdale CG |title=Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets. |journal=Biochem. Biophys. Res. Commun. |volume=163 |issue= 2 |pages= 1071–8 |year= 1989 |pmid= 2783111 |doi=10.1016/0006-291X(89)92330-9 |display-authors=etal}}
  • {{cite journal | vauthors=Holt JC, Rabellino EM, Gewirtz AM |title=Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human platelets and megakaryocytes. |journal=Exp. Hematol. |volume=16 |issue= 4 |pages= 302–6 |year= 1988 |pmid= 2966071 |display-authors=etal}}
  • {{cite journal | vauthors=Castor CW, Furlong AM, Carter-Su C |title=Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III. |journal=Biochemistry |volume=24 |issue= 7 |pages= 1762–7 |year= 1985 |pmid= 4005226 |doi=10.1021/bi00328a029 }}
  • {{cite journal | vauthors=McLaren KM, Pepper DS |title=Immunological localisation of beta-thromboglobulin and platelet factor 4 in human megakaryocytes and platelets. |journal=J. Clin. Pathol. |volume=35 |issue= 11 |pages= 1227–31 |year= 1983 |pmid= 6183294 |doi=10.1136/jcp.35.11.1227 | pmc=497932 }}
  • {{cite journal | vauthors=Castor CW, Miller JW, Walz DA |title=Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=80 |issue= 3 |pages= 765–9 |year= 1983 |pmid= 6572368 |doi=10.1073/pnas.80.3.765 | pmc=393460 |bibcode=1983PNAS...80..765C |doi-access=free }}
  • {{cite journal | vauthors=Malkowski MG, Wu JY, Lazar JB |title=The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7077–87 |year= 1995 |pmid= 7706245 |doi=10.1074/jbc.270.13.7077 |display-authors=etal|doi-access=free }}

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External links

  • {{UCSC gene info|PPBP}}

{{PDB Gallery|geneid=5473}}

{{Chemokines}}

{{Chemokine receptor modulators}}

Category:Cytokines

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