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CXCR6

{{Short description|Mammalian protein found in Homo sapiens}}

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C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.{{cite journal | vauthors = Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM | title = STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1 | journal = The Journal of Experimental Medicine | volume = 185 | issue = 11 | pages = 2015–23 | date = June 1997 | pmid = 9166430 | pmc = 2196334 | doi = 10.1084/jem.185.11.2015 }}{{cite journal | vauthors = Deng HK, Unutmaz D, KewalRamani VN, Littman DR | title = Expression cloning of new receptors used by simian and human immunodeficiency viruses | journal = Nature | volume = 388 | issue = 6639 | pages = 296–300 | date = July 1997 | pmid = 9230441 | doi = 10.1038/40894 | bibcode = 1997Natur.388..296D | s2cid = 4369660 | doi-access = free }}{{cite web | title = Entrez Gene: CXCR6 chemokine (C-X-C motif) receptor 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10663}} CXCR6 has also recently been designated CD186 (cluster of differentiation 186).

CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.{{cite journal | vauthors = Elliott ST, Wetzel KS, Francella N, Bryan S, Romero DC, Riddick NE, Shaheen F, Vanderford T, Derdeyn CA, Silvestri G, Paiardini M, Collman RG | title = Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV | journal = Journal of Virology | volume = 89 | issue = 18 | pages = 9252–61 | date = September 2015 | pmid = 26109719 | doi = 10.1128/JVI.01236-15 | pmc=4542357}} CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.

References

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Further reading

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  • {{cite journal | vauthors = Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM | title = HIV-1 infection and chemokine receptor modulation | journal = Current HIV Research | volume = 2 | issue = 1 | pages = 39–50 | date = January 2004 | pmid = 15053339 | doi = 10.2174/1570162043484997 }}
  • {{cite journal | vauthors = Loetscher M, Amara A, Oberlin E, Brass N, Legler D, Loetscher P, D'Apuzzo M, Meese E, Rousset D, Virelizier JL, Baggiolini M, Arenzana-Seisdedos F, Moser B | title = TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function | journal = Current Biology | volume = 7 | issue = 9 | pages = 652–60 | date = September 1997 | pmid = 9285716 | doi = 10.1016/S0960-9822(06)00292-2 | doi-access = free | bibcode = 1997CBio....7..652L }}
  • {{cite journal | vauthors = Hoffman TL, Stephens EB, Narayan O, Doms RW | title = HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 19 | pages = 11360–5 | date = September 1998 | pmid = 9736741 | pmc = 21647 | doi = 10.1073/pnas.95.19.11360 | bibcode = 1998PNAS...9511360H | doi-access = free }}
  • {{cite journal | vauthors = Schramm B, Penn ML, Speck RF, Chan SY, De Clercq E, Schols D, Connor RI, Goldsmith MA | title = Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease | journal = Journal of Virology | volume = 74 | issue = 1 | pages = 184–92 | date = January 2000 | pmid = 10590105 | pmc = 111527 | doi = 10.1128/JVI.74.1.184-192.2000 }}
  • {{cite journal | vauthors = Tscherning-Casper C, Vödrös D, Menu E, Aperia K, Fredriksson R, Dolcini G, Chaouat G, Barré-Sinoussi F, Albert J, Fenyö EM | title = Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1 | journal = Journal of Acquired Immune Deficiency Syndromes | volume = 24 | issue = 1 | pages = 1–9 | date = May 2000 | pmid = 10877489 | doi = 10.1097/00126334-200005010-00001 | doi-access = free }}
  • {{cite journal | vauthors = Ignatius R, Wei Y, Beaulieu S, Gettie A, Steinman RM, Pope M, Mojsov S | title = The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells | journal = AIDS Research and Human Retroviruses | volume = 16 | issue = 11 | pages = 1055–9 | date = July 2000 | pmid = 10933620 | doi = 10.1089/08892220050075318 }}
  • {{cite journal | vauthors = Unutmaz D, Xiang W, Sunshine MJ, Campbell J, Butcher E, Littman DR | title = The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse | journal = Journal of Immunology | volume = 165 | issue = 6 | pages = 3284–92 | date = September 2000 | pmid = 10975845 | doi = 10.4049/jimmunol.165.6.3284 | s2cid = 2518260 | doi-access = }}
  • {{cite journal | vauthors = Matloubian M, David A, Engel S, Ryan JE, Cyster JG | title = A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo | journal = Nature Immunology | volume = 1 | issue = 4 | pages = 298–304 | date = October 2000 | pmid = 11017100 | doi = 10.1038/79738 | s2cid = 22773861 }}
  • {{cite journal | vauthors = Wilbanks A, Zondlo SC, Murphy K, Mak S, Soler D, Langdon P, Andrew DP, Wu L, Briskin M | title = Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines | journal = Journal of Immunology | volume = 166 | issue = 8 | pages = 5145–54 | date = April 2001 | pmid = 11290797 | doi = 10.4049/jimmunol.166.8.5145 | doi-access = free }}
  • {{cite journal | vauthors = Lee B, Leslie G, Soilleux E, O'Doherty U, Baik S, Levroney E, Flummerfelt K, Swiggard W, Coleman N, Malim M, Doms RW | title = cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor | journal = Journal of Virology | volume = 75 | issue = 24 | pages = 12028–38 | date = December 2001 | pmid = 11711593 | pmc = 116098 | doi = 10.1128/JVI.75.24.12028-12038.2001 }}
  • {{cite journal | vauthors = Calabresi PA, Yun SH, Allie R, Whartenby KA | title = Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells | journal = Journal of Neuroimmunology | volume = 127 | issue = 1–2 | pages = 96–105 | date = June 2002 | pmid = 12044980 | doi = 10.1016/S0165-5728(02)00106-6 | s2cid = 46059196 }}
  • {{cite journal | vauthors = Kim CH, Johnston B, Butcher EC | title = Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity | journal = Blood | volume = 100 | issue = 1 | pages = 11–6 | date = July 2002 | pmid = 12070001 | doi = 10.1182/blood-2001-12-0196 | s2cid = 37076470 | doi-access = free }}
  • {{cite journal | vauthors = Duggal P, An P, Beaty TH, Strathdee SA, Farzadegan H, Markham RB, Johnson L, O'Brien SJ, Vlahov D, Winkler CA | title = Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans | journal = Genes and Immunity | volume = 4 | issue = 4 | pages = 245–50 | date = June 2003 | pmid = 12761559 | doi = 10.1038/sj.gene.6363950 | s2cid = 6657058 | doi-access = }}
  • {{cite journal | vauthors = Koprak S, Matheravidathu S, Springer M, Gould S, Dumont FJ | title = Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin | journal = Cellular Immunology | volume = 223 | issue = 1 | pages = 1–12 | date = May 2003 | pmid = 12914753 | doi = 10.1016/S0008-8749(03)00130-8 }}
  • {{cite journal | vauthors = Shimaoka T, Nakayama T, Fukumoto N, Kume N, Takahashi S, Yamaguchi J, Minami M, Hayashida K, Kita T, Ohsumi J, Yoshie O, Yonehara S | title = Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells | journal = Journal of Leukocyte Biology | volume = 75 | issue = 2 | pages = 267–74 | date = February 2004 | pmid = 14634054 | doi = 10.1189/jlb.1003465 | s2cid = 18245723 }}

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External links

  • {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2873 | title = Chemokine Receptors: CXCR6 | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology }}
  • {{UCSC gene info|CXCR6}}

{{NLM content}}

{{Chemokine receptors}}

{{Clusters of differentiation}}

{{Chemokine receptor modulators}}

Category:Clusters of differentiation

Category:Chemokine receptors

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