CXorf36

The CXorf36 gene is located at Xp11.3.File:Genelocation2.png It can be transcribed into 8 different transcript variants, which in turn can produce 6 different isoforms of the protein.{{cite web | title = NCBI AceView: CXorf36| url = https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&org=9606&l=79742| access-date = 2011-04-28}}

The genomic DNA is 52,529 base pairs long, while the longest mRNA that it produces is 4,735 bases long.

CXorf36 is closely surrounded by the following genes on chromosome X:

• DUSP21
• KDM6A
• MIR222
• TBX20

CXorf36 is also surrounded by two other genes on chromosome X that have been implicated in X-linked mental retardation.{{cite journal |vauthors=Tarpey PS, Smith R, Pleasance E, Whibley A, Edkins S, Hardy C, O'Meara S, Latimer C, Dicks E, Menzies A, Stephens P, Blow M, Greenman C, Xue Y, Tyler-Smith C, Thompson D, Gray K, Andrews J, Barthorpe S, Buck G, Cole J, Dunmore R, Jones D, Maddison M, Mironenko T, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Teague J, Butler A, Jenkinson A, Jia M, Richardson D, Shepherd R, Wooster R, Tejada MI, Martinez F, Carvill G, Goliath R, de Brouwer AP, van Bokhoven H, Van Esch H, Chelly J, Raynaud M, Ropers HH, Abidi FE, Srivastava AK, Cox J, Luo Y, Mallya U, Moon J, Parnau J, Mohammed S, Tolmie JL, Shoubridge C, Corbett M, Gardner A, Haan E, Rujirabanjerd S, Shaw M, Vandeleur L, Fullston T, Easton DF, Boyle J, Partington M, Hackett A, Field M, Skinner C, Stevenson RE, Bobrow M, Turner G, Schwartz CE, Gecz J, Raymond FL, Futreal PA, Stratton MR | title = A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation| journal = Nat. Genet. | volume = 41 | issue = 5 | pages = 535–43 |date=May 2009 | pmid = 19377476 | doi = 10.1038/ng.367| pmc=2872007}}

• Synaptophysin
• CASK

The longest protein isoform that is produced by the CXorf36 gene is termed hypothetical protein LOC79742 isoform 1 and is 433 amino acids long.{{cite web | title =NCBI Protein: hypothetical protein LOC79742 isoform 1| url = https://www.ncbi.nlm.nih.gov/protein/NP_789789.2| access-date = May 10, 2011}} The protein has a predicated molecular weight of 48.6 kDa and isoelectric point of 8.11.{{cite web|title=SDSC Biology Workbench |url=http://seqtool.sdsc.edu/CGI/BW.cgi#! |access-date=May 10, 2011 }}{{dead link|date=November 2016 |bot=InternetArchiveBot |fix-attempted=yes }}

The CXorf36 gene protein product contains a region of low complexity from position 16 to position 40.{{cite web | title =MyHits Dotlet| url = http://myhits.isb-sib.ch/cgi-bin/dotlet| access-date = May 10, 2011}}

The CXorf36 protein is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout the structure.{{cite web | title =DTU Center for Biological Sciences, NetPhos| url = http://www.cbs.dtu.dk/services/NetPhos/| access-date = May 10, 2011}} However, many of these sites are predicted at serines. There is also a predicted N-linked glycosylation site at position 100 on the protein product.{{cite web | title =DTU Center for Biological Sciences, NetNGlyc| url = http://www.cbs.dtu.dk/services/NetNGlyc/| access-date = May 10, 2011}}

CXorf36 is shown to be expressed ubiquitously at low levels in various tissues throughout the body. It is expressed highly in the ciliary ganglion, ovary, and uterus corpus. However, highest expression is seen in the trigeminal ganglion tissue.{{cite web | title =NCBI GEO Profiles: CXorf36| url = https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS596:219652_s_at | access-date = May 10, 2011}}

CXorf36 has one paralog in humans known as C3orf58.{{cite web | title = KEGG: C3orf58| url = http://www.genome.jp/dbget-bin/www_bget?hsa:205428| access-date = May 10, 2011}} Orthologs have been found in all mammals and through numerous eukaryotes.{{cite web | title = NCBI BLAST| url = http://blast.ncbi.nlm.nih.gov/Blast.cgi| access-date = May 9, 2011}} However, conservation of the full gene halts past this, most likely a result of duplication from the ancestral gene into CXorf36 and C3orf58. The full list of organisms in which orthologs have been found is given below.

{{div col|colwidth=20em}}

• Pongo abelii
• Macaca mulatta
• Callithrix jacchus
• Canis familiaris
• Ailuropoda melanoleuca
• Equus caballus
• Oryctolagus cuniculus
• Mus musculus
• Rattus norvegicus
• Monodelphis domestica
• Ornithorhynchus anatinus
• Taeniopygia guttata
• Gallus gallus
• Danio rerio
• Bos taurus

{{div col end}}

{{reflist}}

• {{UCSC gene info|CXorf36}}

{{refbegin | 2}}

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{{DEFAULTSORT:Cxorf36}}

Category:Human proteins

Category:Uncharacterized proteins

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