CYP6 family

{{Short description|Group of cytochrome P450 enzymes}}

Cytochrome P450, family 6, also known as CYP6, is a cytochrome P450 family found in Insect genome. CYP6 and CYP9, another insect CYP family, belong to the same clan as mammalian CYP3 and CYP5 families.{{cite journal |last1=Nelson |first1=DR |title=Metazoan cytochrome P450 evolution. |journal=Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology |date=November 1998 |volume=121 |issue=1–3 |pages=15–22 |doi=10.1016/s0742-8413(98)10027-0 |pmid=9972448}}

The first two CYP6 subfamilies represented by CYP6A1 and CYP6B1 shared only 32.7% identity,{{cite journal |last1=Dermauw |first1=W |last2=Van Leeuwen |first2=T |last3=Feyereisen |first3=R |title=Diversity and evolution of the P450 family in arthropods. |journal=Insect Biochemistry and Molecular Biology |date=December 2020 |volume=127 |pages=103490 |doi=10.1016/j.ibmb.2020.103490 |pmid=33169702|s2cid=226297890 |doi-access=free |bibcode=2020IBMB..12703490D |hdl=1854/LU-8689608 |hdl-access=free }} less than the typical CYP subfamilies, which share at least 40% amino acid identity.{{cite book |last1=Nelson |first1=DR |title=Cytochrome P450 Protocols |chapter=Cytochrome P450 Nomenclature, 2004 |series=Methods in Molecular Biology |date=2006 |volume=320 |pages=1–10 |doi=10.1385/1-59259-998-2:1 |pmid=16719369|isbn=1-59259-998-2 }}

Many of the enzymes in this family like CYP6G1 (DDT-R) in Drosophila melanogaster{{cite journal |last1=Le Goff |first1=G |last2=Hilliou |first2=F |title=Resistance evolution in Drosophila: the case of CYP6G1. |journal=Pest Management Science |date=March 2017 |volume=73 |issue=3 |pages=493–499 |doi=10.1002/ps.4470 |pmid=27787942}} and CYP6B in Helicoverpa armigera{{cite journal |last1=Shi |first1=Y |last2=Jiang |first2=Q |last3=Yang |first3=Y |last4=Feyereisen |first4=R |last5=Wu |first5=Y |title=Pyrethroid metabolism by eleven Helicoverpa armigera P450s from the CYP6B and CYP9A subfamilies. |journal=Insect Biochemistry and Molecular Biology |date=August 2021 |volume=135 |pages=103597 |doi=10.1016/j.ibmb.2021.103597 |pmid=34089822|bibcode=2021IBMB..13503597S |s2cid=235353940 }} are related to insecticide resistance.