Calphostin

{{Short description|Class of fungi}}

The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides.{{Cite journal | journal = Journal of Antibiotics | year = 1989 | volume = 42 | pages = 1470–1474 | author1 = Kobayashi, E | author2 = Ando, K | author3 = Nakano, H | author4 = Iida, T | author5 = Ohno, H | author6 = Morimoto, M | author7 = Tamaoki, T | pmid = 2478514 | title = Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities | issue = 10 | doi=10.7164/antibiotics.42.1470| doi-access = free }}{{cite journal | journal = Journal of Antibiotics | year = 1989 | volume = 42 | pages = 1475–1481 | author1 = Iida, T | author2 = Kobayashi, E | author3 = Yoshida, M | author4 = Sano, H | pmid = 2478515 | title = Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures | issue = 10 | doi=10.7164/antibiotics.42.1475| doi-access = free }} The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity.{{cite web |url=https://www.biomol.com/products/chemicals/biochemicals/calphostin-c-cay15383-100?fs=4064629640 |title=Calphostin C |publisher=Biomol GmbH |access-date=11 October 2024 }}