Calx-beta motif

{{Short description|Protein motif}}

{{Infobox protein family

| Symbol = Calx-beta

| Name = Calx-beta

| image = PDB 2fws EBI.jpg

| width =

| caption = first ca2+ binding domain of the na,ca-exchanger (ncx1)

| Pfam = PF03160

| Pfam_clan =

| InterPro = IPR003644

| SMART =

| PROSITE =

| MEROPS =

| SCOP =

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD =

}}

In molecular biology, the calx-beta motif is a protein motif which is present as a tandem repeat in the cytoplasmic domains of Calx sodium-calcium exchangers, which are used to expel calcium from cells. This motif overlaps domains used for calcium binding and regulation. The calx-beta motif is also present in the cytoplasmic tail of mammalian integrin-beta4, which mediates the bi-directional transfer of signals across the plasma membrane, as well as in some cyanobacterial proteins. This motif contains a series of beta-strands and turns that form a self-contained beta-sheet.{{cite journal | vauthors = Schwarz EM, Benzer S | title = Calx, a Na-Ca exchanger gene of Drosophila melanogaster | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 19 | pages = 10249–54 | date = September 1997 | pmid = 9294196 | pmc = 23348 | doi = 10.1073/pnas.94.19.10249 | bibcode = 1997PNAS...9410249S | doi-access = free }}{{cite journal | vauthors = Schwarz E, Benzer S | title = The recently reported NIbeta domain is already known as the Calx-beta motif | journal = Trends in Biochemical Sciences | volume = 24 | issue = 7 | pages = 260 | date = July 1999 | pmid = 10390612 | doi = 10.1016/S0968-0004(99)01422-X | doi-access = free }}