Canadian Reference Materials

File:NIMS-1 NRC certified reference material.jpg | year = 2013 | volume = 85 | pages = 1047–1078 | issue = 5|display-authors=etal| doi-access = free | hdl = 11858/00-001M-0000-0013-7A21-3 | hdl-access = free }}]]

NRC produces certified reference materials of biological tissues, isotopic standards, natural waters, sediments, supplements, and natural health products. With the exception of the ORMS, the river water CRM with elevated mercury, all materials contain natural levels of analytes in their native matrix.

• Biological tissues
• DOLT, dogfish liver for trace metals
• DORM, fish protein for trace metals
• LUTS, non-defatted lobster hepatopancreas for trace metals
• TORT, lobster hepatopancreas for trace metals
• Isotopic materials
• NIMS, natural inorganic mercury standard
• EMMS, isotopic methylmercury standard
• Natural waters
• CASS, near-shore seawater for trace metals
• MOOS, seawater for nutrients
• NASS, seawater for trace metals
• ORMS, river water for mercury
• SLEW, estuarine water for trace metals
• SLRS, river water for trace metals
• Sediments
• HISS and MESS, marine sediment for trace metals and major constituents
• PACS and SOPH, marine sediment for trace metals and major constituents
• Supplements and natural health products
• CACB, calcium carbonate for lead and cadmium
• FEBS, otolith for trace metals
• SELM, selenium-enriched yeast for selenium

In 1977, Edmonds et al. reported the identification, isolation, and synthesis of major arsenic-containing substance in sea organisms, the arsenobetaine.{{cite journal|author1=John S. Edmonds |author2=Kevin A. Francesconi |author3=Jack R. Cannon |author4=Colin L. Raston|authorlink4=Colin Raston |author5=Brian W. Skelton |author6=Allan H. White |journal= Tetrahedron Letters|year=1977| title= Isolation, crystal structure and synthesis of arsenobetaine, the arsenical constituent of the western rock lobster panulirus longipes Cygnus Roger| volume=18|issue=18 |pages= 1543–1546|doi= 10.1016/S0040-4039(01)93098-9}} In 1999, NRC certified arsenobetaine in the dogfish muscle material DORM-2, which became the first matrix reference material certified for arsenobetaine. Before DORM-2, DORM-1 (issued in 1986) served as the reference material for which the concentration of arsenobetaine was widely reported in scientific literature.{{cite journal |author1=Walter Goessler |author2=Doris Kuehnelt |author3=Claudia Schlagenhaufen |author4=Zdenka Slejkovec |author5=Kurt J. Irgolic |title= Arsenobetaine and other arsenic compounds in the National Research Council of Canada Certified Reference Materials DORM 1 and DORM 2|journal= Journal of Analytical Atomic Spectrometry |year=1998|volume= 13|issue=3 |pages=183–187 |doi=10.1039/A705634F }} Besides arsenobetaine, NRC currently offers matrix reference materials certified for methylmercury (TORT-3), dibutyltin, and tributyltin (PACS-3).

• Biological tissues and sediments
• CARP, fish for dioxins, furans, and PCBs
• DOLT, dogfish liver for methylmercury
• DORM, fish protein for methylmercury
• TORT, lobster hepatopancreas for methylmercury and arsenobetaine
• PACS and SOPH, marine sediment for dibutyltin and tributyltin
• SELM, selenium-enriched yeast for methionine and selenomethionine

File:Domoic acid skeletal formula.svg

In 1987 Canada witnessed a crisis in the seafood industry. Shellfish toxins present in PEI mussels caused amnesic shellfish poisoning taking several lives.{{cite book |last=Wright |first=Jeffrey L.C. |editor-first=Cynthia |editor-last= Lamson |title= The Sea Has Many Voices: Oceans Policy for a Complex World|publisher=McGill-Queen's University Press |year=1994 |pages=247–262 |chapter=Chapter 13: Toxic-Shellfish Crisis: 1987 and Beyond |isbn=978-0-7735-1112-5}} In response, shellfish toxin research was initiated at NRC Canada. Today, NRC remains the premier producer of biotoxin CRMs in the world and is recognized for its expertise.{{cite web|url=http://theanalyticalscientist.com/the-power-list-2013/michael-quilliam/|title=The Analytical Scientist Power List 2013: Michael Quilliam|year=2013|access-date=2014-01-13|archive-url=https://web.archive.org/web/20140115051035/http://theanalyticalscientist.com/the-power-list-2013/michael-quilliam/|archive-date=2014-01-15|url-status=dead}}

• Amnesic shellfish poisoning toxins
• ASP-Mus-d, mussel tissue for domoic acid and its isomers
• DA-f, domoic acid standard
• Diarrhetic shellfish poisoning and other lipophilic toxins
• AZA, azaspiracid standards
• DSP-Mus, mussel tissue for okadaic acid
• OA, okadaic acid standard
• DTX, dinophysistoxin standards
• GYM, gymnodimine standards
• YTX and {{Proper name|hYTX}}, yessotoxin standards
• PTX, pectenotoxin-2 standard
• SPX, 13-desmethyl spirolide C standard
• Microcystins
• {{Proper name|dmMCLR}} and MCLR, microcystin-LR standards
• MCRR, microcystin-RR standard
• NODR, nodularin-R standard
• Paralytic shellfish poisoning toxins
• C1&2, N-sulfocarbamoyl-gonyautoxin standard
• {{Proper name|dcGTX}} and GTX, decarbamoyl-gonyautoxin and gonyautoxin standards
• {{Proper name|dcNEO}} and NEO, decarbamoyl-neosaxitoxin and neosaxitoxin standards
• {{Proper name|dcSTX}} and STX, decarbamoyl-saxitoxin and saxitoxin standards
• Cyanobacterial toxins
• ATX, anatoxin-a standard
• CYN, cylindrospermopsin standard

• Certified reference materials

{{reflist|30em}}

• {{Official website|http://www.nrc-cnrc.gc.ca/eng/solutions/advisory/crm_index.html}}
• [https://nrc-digital-repository.canada.ca/eng/home/collection/Canadian%20Reference%20Materials%20and%20Methods/ Canadian Reference Materials and Methods (National Science Library, Digital Repository)]

Category:Analytical chemistry

Category:Measurement

Category:Standards of Canada

Category:Biochemistry