Canals of Hering
{{Use American English|date = February 2019}}
{{Short description|Part of the liver}}
{{Infobox anatomy
| Name = Canals of Hering
| Latin = ductulus bilifer
| Image = Hepatic structure2.svg
| Caption = The canal of Hering, not labeled, leads to the bile ductule
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The canals of Hering, or intrahepatic bile ductules, are part of the outflow system of exocrine bile product from the liver. Liver stem cells are hypothesized to inhabit the canals.{{cite journal | last=Oliva | first=Joan | last2=French | first2=Barbara A. | last3=Qing | first3=X. | last4=French | first4=Samuel W. | title=The identification of stem cells in human liver diseases and hepatocellular carcinoma | journal=Experimental and Molecular Pathology | publisher=Elsevier BV | volume=88 | issue=3 | year=2010 | issn=0014-4800 | doi=10.1016/j.yexmp.2010.01.003 | pages=331–340| pmc=3593713 }}{{cite journal | last=De Alwis | first=Nimantha | last2=Hudson | first2=Gavin | last3=Burt | first3=Alastair D. | last4=Day | first4=Christopher P. | last5=Chinnery | first5=Patrick F. | title=Human liver stem cells originate from the canals of hering | journal=Hepatology | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=50 | issue=3 | date=2009-07-07 | issn=0270-9139 | doi=10.1002/hep.23160 | pages=992–993| doi-access=free }}
Structure
They are found between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule.Ross, M.H. & Pawlina, W. 2003. Histology: A Text and Atlas, 4th Edition. Lippincott Williams & Wilkins, Philadelphia.Gartner, L.P. & Hiatt, J.L. 2000. Color Atlas of Histology, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia.
=Histology=
Histologically, the cells of the ductule are described as simple cuboidal epithelium, lined partially by cholangiocytes and hepatocytes. They may not be readily visible but can be differentially stained by cytokeratins CK19 and CK7.
Clinical relevance
The canals of Hering are destroyed early in primary biliary cholangitis and may be primary sites of scarring in methotrexate toxicity. Research has indicated the presence of intraorgan stem cells of the liver that can proliferate in disease states, so-called oval cells.Saxena, R. & Theise, N. 2004. Canals of Hering: Recent Insights and Current Knowledge, Semin Liver Dis 24: 43-48. Liver stem cells are theorized to originate in the niches of the canals.{{cite journal | last=Kordes | first=Claus | last2=Häussinger | first2=Dieter | title=Hepatic stem cell niches | journal=Journal of Clinical Investigation | publisher=American Society for Clinical Investigation | volume=123 | issue=5 | date=2013-05-01 | issn=0021-9738 | doi=10.1172/jci66027 | pages=1874–1880| pmc=3638908 }}
History
References
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