Cancer (film)

{{short description|2015 American documentary film}}

{{use mdy dates|date=March 2015}}

{{Infobox television

| alt_name = Cancer: The Emperor of All Maladies

| image = Cancer-BluRayCover.jpg

| image_size = 150

| caption = Blu-ray cover

| genre = Documentary film

| creator =

| based_on = {{Based on|The Emperor of All Maladies: A Biography of Cancer|Siddhartha Mukherjee}}

| writer = {{Plain list|

}}

| director = Barak Goodman

| starring = Dr. Siddhartha Mukherjee

| narrated = Edward Herrmann

| composer = David Cieri

| country = United States

| language = English

| num_episodes = 3

| producer = Barak Goodman

| cinematography = {{Plain list|

  • Robert Hanna
  • Stephen McCarthy
  • Sam Russell

}}

| editor = {{Plain list|

  • Peter R. Livingston Jr.
  • Karen K. H. Sim
  • Nancy Novack

}}

| runtime = {{convert|6|hour|minute|abbr=on}}

| company = {{Plain list|

}}

| network = PBS

| released = {{Start date|2015|03|30}}

}}

Cancer: The Emperor of All Maladies is a 2015 American documentary film produced and directed by Barak Goodman and executive produced by Ken Burns.{{cite news|last=Genzlinger|first=Neil|title=Review: In 'Cancer: The Emperor of All Maladies,' Battling an Opportunistic Killer|url=https://www.nytimes.com/2015/03/28/arts/television/review-in-cancer-the-emperor-of-all-maladies-battling-an-opportunistic-killer.html |date=March 27, 2015|work=The New York Times|accessdate=March 31, 2015}}{{cite news|last=McNamara|first=Mary|title=Review: PBS' 'Cancer' documentary cuts to the heart of the matter|url=http://www.latimes.com/entertainment/la-et-st-cancer-review-20150330-column.html|date=March 30, 2015|work=Los Angeles Times|accessdate=April 1, 2015}}{{cite news|last=Szabo|first=Liz|title=Ken Burns tackles history of cancer|url=https://www.usatoday.com/story/life/tv/2015/03/29/pbs-cancer-documentary/70349126/|date=March 29, 2015|work=USA Today|accessdate=April 1, 2015}}{{cite news|last=Herper|first=Matthew|title=What I Hope Everyone Learns From PBS' Big Cancer Documentary|url=https://www.forbes.com/sites/matthewherper/2015/03/31/what-i-hope-everyone-learns-from-pbs-big-cancer-documentary/|date=March 31, 2015|work=Forbes|accessdate=April 1, 2015}} The film, in three episodes of two hours each, is based on the Pulitzer Prize–winning 2010 book The Emperor of All Maladies: A Biography of Cancer, by Siddhartha Mukherjee, and describes the history of cancer and cancer treatments, particularly in the United States.

The film is narrated by Edward Herrmann, who was himself suffering from terminal brain cancer at the time of its production. He died on December 31, 2014, three months before the film's release, making the series his final performance.{{cite news |last=Oldenburg |first=Ann |title='Gilmore Girls' actor Edward Herrmann dies |url=https://www.usatoday.com/story/life/people/2014/12/31/edward-herrmann-dies-at-age-71/21115593/ |date=January 1, 2015 |work=USA Today |access-date=August 23, 2015 }}

Episodes

class="wikitable plainrowheaders"

! style="background:#dedde2"| No.

! style="background:#dedde2"| Episode{{cite web |author=Staff |title=Cancer - Episode Guide |url=https://www.pbs.org/kenburns/cancer-emperor-of-all-maladies/about-film/episode-one/ |publisher=PBS |date=2015 |accessdate=March 31, 2015 }}

! style="background:#dedde2"| Original air date

{{ Episode list

|EpisodeNumber=1

|Title=Magic Bullets

|RTitle= (to 1970)

|OriginalAirDate={{Start date|2015|03|30}}{{cite web |author=Staff |title=Cancer - Episode 01 |url=https://www.pbs.org/kenburns/cancer-emperor-of-all-maladies/about-film/episode-one/ |publisher=PBS |date=2015 |accessdate=March 31, 2015 }}

|ShortSummary=A summary of the history of cancer is presented. Dr. Sidney Farber pioneers chemotherapy while William Halsted pioneers surgical oncology. Emil Grubbe comes up with radiation treatment.

Louis Goodman and Alfred Gilman begin targeting cancer cells with nitrogen mustard. The beginning of the "war on cancer" in the United States is presented. VAMP is discussed.

|LineColor=DEDDE2

}}

{{ Episode list

|EpisodeNumber=2

|Title=The Blind Men and the Elephant

|RTitle= (1970–2000)

|OriginalAirDate={{Start date|2015|03|31}}{{cite web |author=Staff |title=Cancer - Episode 02 |url=https://www.pbs.org/kenburns/cancer-emperor-of-all-maladies/about-film/episode-two/ |publisher=PBS |date=2015 |accessdate=March 31, 2015 }}

|ShortSummary=The basic nature of cancer cells, the role of viral and chemical carcinogens, and a relationship of cancer to genes, are described. Several successful cancer therapies are examined.

The 1950 Wynder and Graham Study is reviewed. The research of Bradford Hill and Richard Doll is covered with respect to chemical carcinogenesis.


Bruce Ames zeros in on mutagens. J. Michael Bishop and Harold Varmus study the oncogene SRC. Robert Weinberg is interviewed discussing his search for a human oncogene and his finding of Ras.

William P. Peters develops the Solid Tumor Autologous Marrow Program (STAMP) regimen.

Tamoxifen is invented in the 1970s.

It is discovered that antibodies within the human immune system can fight oncogenes. Siddhartha Mukherjee says, "You could think of antibodies as intensely, exquisitely targeted missiles made in the body to target virus, bacteria, or other cells."

Brian Druker, working with Charles Sawyers and Nicholas Lydon among others, becomes interested in a fatal blood cancer known as CML following Janet Rowley's work in the 1970s.

|LineColor=DEDDE2

}}

{{ Episode list

|EpisodeNumber=3

|Title=Finding the Achilles Heel

|RTitle= (2000–2015)

|OriginalAirDate={{Start date|2015|04|01}}{{cite web |author=Staff |title=Cancer - Episode 03 |url=https://www.pbs.org/kenburns/cancer-emperor-of-all-maladies/about-film/episode-three/ |publisher=PBS |date=2015 |accessdate=March 31, 2015 }}

|ShortSummary=Bert Vogelstein sets out to learn more about mutated cancer genes. Following the Human Genome Project, The Cancer Genome Atlas begins in 2005. The opposite of oncogenes, tumor suppressor genes, are discovered. Further complexities in the history of cancer are revealed and new immunological approaches{{cite news|last=Gallagher|first=James|title=Health - Personal cancer vaccine research 'exciting' say experts|url=https://www.bbc.com/news/health-32162799|date=April 3, 2015|publisher=BBC News|accessdate=April 3, 2015}} are considered. William Coley is a pioneer in immune therapy. Jim Allison develops Yervoy.

John Banzhaf convinces the Federal Communications Commission to rule that anti-smoking advertisements need to be aired on television to counter the tobacco company ads.

Mary-Claire King finds the BRCA1 gene on human chromosome 17.

|LineColor=DEDDE2

}}

Participants

Gallery

Image:Nci-vol-8226-300 bernard fisher.jpg|Dr. Bernard Fisher

Image:Dr. Siddhartha Mukherjee 2011.jpg|Dr. Siddhartha Mukherjee

Image:Sidney Farber nci-vol-1926-300.jpg|Dr. Sidney Farber

Image:Dr. Susan Love.jpg|Dr. Susan Love

Image:Mary Lasker.jpg|Mary Lasker

Critical response

According to a review in the Los Angeles Times, the film is "the single most personally relevant documentary of this or any year". According to a review in The New York Times, the series is "absorbing", is "structured as an ever-evolving medical detective story, but the filmmakers give it heart as well by juxtaposing the history lessons with present-day personal profiles of cancer patients", seems perhaps "too much like a promotional video for cancer researchers and hospitals", and "touches only briefly on the significant issue of costs" but "achieves its main goal, which is to show the human impact of cancer."

See also

References

{{reflist|2}}