Carboxyamidotriazole

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| verifiedrevid = 424714567

| ImageFile = Carboxyamidotriazole.svg

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| PIN = 5-Amino-1-{[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl}-1H-1,2,3-triazole-4-carboxamide

| OtherNames =

|Section1={{Chembox Identifiers

| CASNo_Ref = {{cascite|correct|??}}

| CASNo= 99519-84-3

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 6ST3ZF52WB

| PubChem= 108144

| EINECS = 804-580-3

| SMILES=C1=CC(=CC=C1C(=O)C2=C(C=C(C=C2Cl)CN3C(=C(N=N3)C(=O)N)N)Cl)Cl

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = 97232

| InChI = 1/C17H12Cl3N5O2/c18-10-3-1-9(2-4-10)15(26)13-11(19)5-8(6-12(13)20)7-25-16(21)14(17(22)27)23-24-25/h1-6H,7,21H2,(H2,22,27)

| InChIKey = WNRZHQBJSXRYJK-UHFFFAOYAY

| StdInChI_Ref = {{stdinchicite|changed|chemspider}}

| StdInChI = 1S/C17H12Cl3N5O2/c18-10-3-1-9(2-4-10)15(26)13-11(19)5-8(6-12(13)20)7-25-16(21)14(17(22)27)23-24-25/h1-6H,7,21H2,(H2,22,27)

| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}

| StdInChIKey = WNRZHQBJSXRYJK-UHFFFAOYSA-N

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|Section2={{Chembox Properties

| Formula=C17H12Cl3N5O2

| MolarMass=424.66848

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|Section3={{Chembox Hazards

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Carboxyamidotriazole is a calcium channel blocker that blocks voltage-gated and ligand-gated calcium channels and has been investigated as an anti-cancer drug in vitro.{{cite journal|pmid=9816048|year=1995|last1=Figg|first1=W. D.|last2=Cole|first2=K. A.|last3=Reed|first3=E.|last4=Steinberg|first4=S. M.|last5=Piscitelli|first5=S. C.|last6=Davis|first6=P. A.|last7=Soltis|first7=M. J.|last8=Jacob|first8=J.|last9=Boudoulas|first9=S.|last10=Goldspiel|first10=B.|title=Pharmacokinetics of orally administered carboxyamido-triazole, an inhibitor of calcium-mediated signal transduction|journal=Clinical Cancer Research |volume=1|issue=8|pages=797–803}}{{cite journal|pmid=30338034|pmc=6188062|year=2018|last1=Bonnefond|first1=M. L.|last2=Florent|first2=R.|last3=Lenoir|first3=S.|last4=Lambert|first4=B.|last5=Abeilard|first5=E.|last6=Giffard|first6=F.|last7=Louis|first7=M. H.|last8=Elie|first8=N.|last9=Briand|first9=M.|last10=Vivien|first10=D.|last11=Poulain|first11=L.|last12=Gauduchon|first12=P.|last13=n'Diaye|first13=M.|title=Inhibition of store-operated channels by carboxyamidotriazole sensitizes ovarian carcinoma cells to anti-BCLXL strategies through MCL-1 down-regulation|journal=Oncotarget|volume=9|issue=74|pages=33896–33911|doi=10.18632/oncotarget.26084}}

References