Carlos Caldas
{{Infobox scientist
| name = Carlos Caldas
| honorific_suffix = {{post-nominals|country=GBR|FMedSci|size=100%}}
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| birth_name = Carlos Manuel Simão da Silva Caldas
| birth_date = 27 June 1960
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| workplaces = University of Cambridge
Addenbrooke's Hospital
Robinson College, Cambridge
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| alma_mater = University of Lisbon Medical School
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| awards = Fellow of the Academy of Medical Sciences
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| website = https://www.oncology.cam.ac.uk/directory/c-caldas
}}
Professor Carlos Caldas {{post-nominals|country=GBR|4=FMedSci}} is a clinician scientist and Professor of Cancer Medicine at the University of Cambridge. He is the Chair of Cancer Medicine at the University of Cambridge, an Honorary Consultant Medical Oncologist at Addenbrooke's Hospital and was the Founding Director of the Cambridge Breast Cancer Research Unit.{{Cite web|url=https://www.cuh.nhs.uk/cambridge-breast-unit/meet-team/oncologists/prof-c-caldas|title=Prof C Caldas {{!}} Cambridge University Hospitals|website=www.cuh.nhs.uk|access-date=2019-08-29}}{{Cite web|url=https://www.oncology.cam.ac.uk/directory/c-caldas|title=Professor Carlos Caldas — Department of Oncology|last=kla29@cam.ac.uk|website=www.oncology.cam.ac.uk|access-date=2019-08-29}} He is a fellow of Robinson College, Cambridge[https://www.robinson.cam.ac.uk/people/professor-carlos-caldas-fmedsci Caldas's Robinson College webpage] and an Emeritus Senior Investigator at the National Institute for Health Research (NIHR).{{Cite web|title=NIHR Senior Investigators 2020|url=https://www.nihr.ac.uk/documents/nihr-senior-investigators-2020-list-of-13th-round-appointments/24106|access-date=2022-02-09|website=NIHR}}
Education
Professor Carlos Caldas graduated from the University of Lisbon Medical School before training in Internal Medicine in University of Texas Southwestern, Dallas and Medical Oncology at Johns Hopkins Hospital, Baltimore. He then moved to the Institute of Cancer Research, London to complete a research fellowship.
Research and career
Caldas' research focuses on the functional genomics of breast cancer.{{Cite web|url=https://scholar.google.co.uk/citations?user=cWlqL14AAAAJ&hl=en|title=Carlos Caldas - Google Scholar Citations|website=scholar.google.co.uk|access-date=2019-08-29}}{{Cite web|url=https://www.cruk.cam.ac.uk/research-groups/caldas-group|title=Caldas Group|website=Cancer Research UK Cambridge Institute|access-date=2019-08-29}} Caldas led the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) study, analysing the genome and transcriptome of tumours from nearly 2,000 women and comparing this with long-term clinical information including survival, age and diagnosis. The METABRIC study concluded that breast cancer was at least ten different subtypes, characterised by distinct genomic drivers.{{Cite journal|last1=Aparicio|first1=Samuel|last2=Caldas|first2=Carlos|last3=Tavaré|first3=Simon|last4=Brenton|first4=James D.|last5=Børresen-Dale|first5=Anne-Lise|last6=Purushotham|first6=Arnie|last7=Ellis|first7=Ian|last8=Murphy|first8=Leigh|last9=Markowetz|first9=Florian|date=June 2012|title=The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups|journal=Nature|volume=486|issue=7403|pages=346–352|doi=10.1038/nature10983|pmid=22522925|issn=1476-4687|pmc=3440846|bibcode=2012Natur.486..346.}}{{Cite news|url=https://www.bbc.com/news/health-17740690|title=Breast cancer map 'a key moment'|last=Gallagher|first=James|date=2012-04-18|access-date=2019-08-29}} In 2019, the team published research showing the subtype a women's breast cancer is initially placed in could predict the likelihood of the tumour returning or metastasising over the next 20 years.{{Cite journal|last1=Curtis|first1=Christina|last2=Caldas|first2=Carlos|last3=Aparicio|first3=Samuel|last4=Rueda|first4=Cristina|last5=Pharoah|first5=Paul D.|last6=Ellis|first6=Ian O.|last7=Purushotham|first7=Arnie|last8=Murphy|first8=Leigh|last9=Green|first9=Andrew R.|date=March 2019|title=Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups|journal=Nature|volume=567|issue=7748|pages=399–404|doi=10.1038/s41586-019-1007-8|pmid=30867590|issn=1476-4687|pmc=6647838|bibcode=2019Natur.567..399R}}{{Cite news|url=https://www.bbc.com/news/health-47553534|title=Cancer's 'internal wiring' predicts relapse risk|last=Gallagher|first=James|date=2019-03-14|access-date=2019-08-29}}{{Cite web|url=https://www.independent.co.uk/news/health/breast-cancer-test-return-risk-calculator-genetic-cambridge-study-a8821476.html|title=Breast cancer test could predict chances of disease's return 20 years later, study shows|date=2019-03-13|website=The Independent|access-date=2019-08-29}}
Professor Caldas leads the Personalised Breast Cancer Programme in Cambridge, where woman diagnosed with breast cancer have a sample of their tumour and blood sent for DNA and RNA sequencing. The sequencing results help determine the best course of treatment for patients and can reveal if their tumour is developing resistance to treatment.{{Cite news|url=https://www.bbc.com/news/health-44455354|title=DNA 'barcode' can transform cancer care|last=Walsh|first=Fergus|date=2018-06-27|access-date=2019-08-29}}{{Cite web|url=https://www.cambridge-news.co.uk/news/health/breast-cancer-dna-barcode-addenbookes-14942750|title=Breast cancer DNA 'barcoding' programme set to expand|last=Pilgrim|first=Tom|date=2018-07-23|website=cambridgenews|access-date=2019-08-29}}{{Cite web|url=https://www.cuh.nhs.uk/news/breast-unit/pbcp-study-takes-breast-cancer-research-next-level-development-personalised-cancer-medicine|title=PBCP study takes breast cancer research to the next level in the development of personalised cancer medicine {{!}} Cambridge University Hospitals|website=www.cuh.nhs.uk|access-date=2019-08-29}}
Awards and honours
- Academy of Medical Sciences Fellow, 2004{{Cite web|url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-Carlos-Caldas-0006182|title=Professor Carlos Caldas {{!}} The Academy of Medical Sciences|website=acmedsci.ac.uk|access-date=2019-08-29}}
- European Academy of Cancer Sciences Fellow, 2010{{Cite web|url=https://www.europeancanceracademy.eu/content/directory.php|title=Fellows{{!}} European Academy of Cancer Sciences|website=www.europeancanceracademy.eu|access-date=2019-08-29|archive-date=2019-07-04|archive-url=https://web.archive.org/web/20190704091011/https://www.europeancanceracademy.eu/content/directory.php|url-status=dead}}
- EMBO member, 2015{{Cite web|url=https://people.embo.org/profile/carlos-caldas|title=Find people in the EMBO Communities|website=people.embo.org|access-date=2019-08-29}}{{Cite web|url=https://www.cruk.cam.ac.uk/2015/05/20/three-cruk-ci-group-leaders-elected-to-embo-membership|title=Three Group Leaders elected to EMBO Membership|date=2015-05-20|website=Cancer Research UK Cambridge Institute|access-date=2019-08-29}}
- European Society for Medical Oncology Hamilton Fairley Award, 2016{{Cite web|url=https://www.esmo.org/Press-Office/ESMO-Recognises-Carlos-Caldas-with-Hamilton-Fairley-Award|title=Press Release: ESMO Recognises Carlos Caldas with Hamilton Fairley Award {{!}} ESMO|website=www.esmo.org|access-date=2019-08-29}}
- European Society of Human Genetics ESHG Award Laureate, 2021{{Cite web|url=https://2021.eshg.org/eshg-award/|title=ESHG Award {{!}} ESHG|website=www.eshg.org|access-date=2021-03-25}}
- Susan G. Komen Brinker Award for Scientific Distinction in Basic Science, 2021
- 51st Fondation ARC Leopold Griffuel Award, 2023
References
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Category:Fellows of the Academy of Medical Sciences (United Kingdom)
Category:Members of the European Molecular Biology Organization