Carolyn Bertozzi
{{short description|American chemist (born 1966)}}
{{Use American English|date=October 2022}}
{{Use mdy dates|date=October 2022}}
{{Infobox person
| name = Carolyn Bertozzi
| image = Carolyn Bertozzi by Christopher Michel in 2022 4.jpg
| caption = Bertozzi in 2022
| birth_name = Carolyn Ruth Bertozzi
| birth_date = {{birth date and age|1966|10|10}}
| birth_place = Boston, Massachusetts, U.S.
| death_date =
| death_place =
| education = {{ubl|Harvard University (BA)|University of California, Berkeley (MS, PhD)}}
| known_for = Bioorthogonal chemistry
| relatives = Andrea Bertozzi (sister)
| awards = {{ubl|ACS Award in Pure Chemistry (2001)|Lemelson–MIT Prize (2010)|Heinrich Wieland Prize (2012)|Wolf Prize (2022)|Dickson Prize (2022)|Welch Award in Chemistry (2022)|Nobel Prize in Chemistry (2022)}}
| module = {{Infobox scientist
| child = yes
| fields = Chemistry
| workplaces = {{ubl|Stanford University|University of California, Berkeley|Lawrence Berkeley National Laboratory|University of California, San Francisco}}
| doctoral_advisor = Mark D. Bednarski
| thesis_title = Synthesis and biological activity of carbon-linked glycosides
| thesis_url = https://www.proquest.com/docview/304068526/
| thesis_year = 1993
| doctoral_students = {{Plainlist|
- Lisa Marcaurelle
- Howard Hang
- Mireille Kamariza
- Lara Mahal
- Jennifer Prescher{{Cite thesis |degree=PhD|last=Prescher |first=Jennifer Ann |id={{ProQuest|305348554}} |url=https://search.library.berkeley.edu/permalink/01UCS_BER/1thfj9n/alma991016646109706532 |title=Probing Glycosylation in Living Animals with Bioorthogonal Chemistries |publisher=University of California, Berkeley |date=2006 |language=English |oclc=892833679}}}}
}}
}}
{{external media | width = 210px | float = right | headerimage= |video1= [https://www.ted.com/talks/carolyn_bertozzi_what_the_sugar_coating_on_your_cells_is_trying_to_tell_you "What the sugar coating on your cells is trying to tell you"], TEDx Stanford |video2= [https://www.aaas.org/news/carolyn-r-bertozzi-wins-2022-aaas-lifetime-mentor-award?adobe_mc=MCMID%3D83613660772200808932157120907812278803%7CMCORGID%3D242B6472541199F70A4C98A6%2540AdobeOrg%7CTS%3D1667060068 "Carolyn R. Bertozzi Wins 2022 AAAS Lifetime Mentor Award"], AAAS, 10 February 2022 }}
Carolyn Ruth Bertozzi (born October 10, 1966) is an American chemist and Nobel laureate, known for her wide-ranging work spanning both chemistry and biology. She coined the term "bioorthogonal chemistry"{{Cite web|url=https://www.hhmi.org/scientists/carolyn-r-bertozzi|title=Carolyn R. Bertozzi|website=HHMI.org|language=en|access-date=February 5, 2020}} for chemical reactions compatible with living systems. Her recent efforts include synthesis of chemical tools to study cell surface sugars called glycans and how they affect diseases such as cancer, inflammation, and viral infections like COVID-19.{{Cite web |title=Carolyn Bertozzi {{!}} Department of Chemistry |url=https://chemistry.stanford.edu/people/carolyn-bertozzi |access-date=March 16, 2022 |website=chemistry.stanford.edu}} At Stanford University, she holds the Anne T. and Robert M. Bass Professorship in the School of Humanities and Sciences.{{cite news|last1=Adams|first1=Amy|title=Stanford chemist explains excitement of chemistry to students, the public|url=http://news.stanford.edu/news/2015/june/chemistry-bertozzi-qna-060515.html|accessdate=July 19, 2015|agency=Stanford News}} Bertozzi is also an Investigator at the Howard Hughes Medical Institute (HHMI){{cite news|title=Carolyn Bertozzi honored by GLBT organization|url=http://berkeley.edu/news/berkeleyan/2007/02/21_awards.shtml|accessdate=February 8, 2013|newspaper=UC Berkeley News|date=February 27, 2007}} and is the former director of the Molecular Foundry, a nanoscience research center at Lawrence Berkeley National Laboratory. Since 2024, she has served as a scientific advisory board member of Arc Institute.{{cite news |last1=Adkins |first1=Jessica |title=Arc Institute welcomes first Scientific Advisory Board members; appoints two new members to Board of Directors |url=https://arcinstitute.org/news/news/board-announcement-2024 |access-date=1 April 2025 |date=24 July 2024 |language=en}}
She received the MacArthur "genius" award at age 33.{{cite web|title=Carolyn Bertozzi, Organic Chemist|url=http://www.macfound.org/fellows/600/|website=MacArthur Foundation|accessdate=February 3, 2015}} In 2010, she was the first woman to receive the prestigious Lemelson–MIT Prize faculty award. She is a member of the National Academy of Sciences (2005), the Institute of Medicine (2011), and the National Academy of Inventors (2013). In 2014, it was announced that Bertozzi would lead ACS Central Science, the American Chemical Society's first peer-reviewed open access journal, which offers all content free to the public.{{Cite web|title = Carolyn Bertozzi To Lead ACS Central Science {{!}} Chemical & Engineering News|url = http://cen.acs.org/articles/92/web/2014/09/Carolyn-Bertozzi-Lead-ACS-Central.html|website = cen.acs.org|accessdate = August 19, 2015|first = Linda|last = Wang}} Since 2021 she has been a member of the Accademia dei Lincei.{{Cite web|url=https://www.lincei.it/en/node/9765|title=Alla lincea Carolyn Bertozzi uno dei Nobel per la Chimica 2022 |trans-title=Carolyn Bertozzi one of the 2022 Nobel Prize winners in Chemistry |publisher=Accademia Nazionale dei Lincei |website=www.lincei.it |language=it |access-date=October 7, 2022}}
As an open lesbian in academia and science, Bertozzi has been a role model for students and colleagues.{{cite news|last1=Cassell|first1=Heather|title=Two Bay Area gay scientists honored |url=https://www.ebar.com/story.php?ch=news&sc=&sc2=&id=237708|accessdate=October 5, 2022|work=Bay Area Reporter|date=February 22, 2007}}{{cite web |title=NOGLSTP to Honor Bertozzi, Gill, Mauzey, and Bannochie at 2007 Awards Ceremony in February |accessdate=February 19, 2019 |url=https://www.noglstp.org/publications-documents/announcements/2007-01-21-noglstp-to-honor-bertozzi-gill-mauzey-and-bannochie-at-2007-awards-ceremony-in-february/ |publisher=NOGLSTP}}
Bertozzi was awarded the 2022 Nobel Prize in Chemistry, jointly with Morten P. Meldal and Karl Barry Sharpless, "for the development of click chemistry and bioorthogonal chemistry".{{r|nobelprize}}
Education
Carolyn Bertozzi received her B.A., summa cum laude, in chemistry from Harvard University, where she worked with Professor Joe Grabowski on the design and construction of a photoacoustic calorimeter.{{cite journal |pages=214–26 |doi=10.1016/0003-2697(92)90003-P |title=Fluorescence probes in biochemistry: An examination of the non-fluorescent behavior of dansylamide by photoacoustic calorimetry |year=1992 |last1=Grabowski |first1=Joseph J. |journal=Analytical Biochemistry |volume=207 |issue=2 |pmid=1481973 |last2=Bertozzi |first2=Carolyn R. |last3=Jacobsen |first3=John R. |last4=Jain |first4=Ahamindra |last5=Marzluff |first5=Elaine M. |last6=Suh |first6=Annie Y.}} Grabowski was impressed with her work and required Bertozzi to write a thesis on this project, which was submitted and Bertozzi won the Thomas T. Hoopes Undergraduate Thesis Prize. While an undergraduate, she played in several bands, notably Bored of Education with future Rage Against the Machine guitarist Tom Morello.{{cite web |title=Meet Carolyn Bertozzi |url=http://publications.nigms.nih.gov/chemhealth/chemist_bertozzi.htm |publisher=NIGMS |accessdate=February 8, 2013 |archive-date=October 5, 2017 |archive-url=https://web.archive.org/web/20171005223521/https://publications.nigms.nih.gov/chemhealth/chemist_bertozzi.htm |url-status=dead}}{{Cite web |last=Houlton |first=Sarah |date=January 12, 2018 |title=Carolyn Bertozzi |url=https://www.chemistryworld.com/features/carolyn-bertozzi/3008380.article |access-date=October 7, 2020 |website=Chemistry World |publisher=Royal Society of Chemistry}} After graduating from Harvard in 1988, she worked at Bell Labs with Chris Chidsey.{{Cite web|url=https://inchemistry.acs.org/content/inchemistry/en/acs-and-you/carolyn-bertozzi.html |title=Carolyn Bertozzi' s Winding Road to an Extraordinary Career |work=inChemistry |access-date=February 17, 2020 |first=Eric |last=Stewart |date=March 27, 2017 |publisher=American Chemical Society}}
Bertozzi completed her Ph.D. in chemistry at University of California, Berkeley in 1993 with Mark Bednarski, working on the chemical synthesis of oligosaccharide analogs.{{cite thesis |title=Synthesis and biological activity of carbon-linked glycosides |last=Bertozzi |first=Carolyn Ruth|institution=University of California, Berkeley |degree=Ph.D. |id={{ProQuest|304068526}} |oclc=30660316}}{{cite journal |title=Bertozzi: Infectious In Her Enthusiasm |journal=Chemical & Engineering News |date=January 31, 2000 |volume=78 |issue=5 |pages=26–35}} While at Berkeley, she discovered that viruses can bind to sugars in the body.{{Cite web|url=https://lemelson.mit.edu/winners/carolyn-bertozzi|title=Carolyn Bertozzi {{!}} Lemelson–MIT Program|website=lemelson.mit.edu|access-date=February 5, 2020|archive-date=August 10, 2020|archive-url=https://web.archive.org/web/20200810095535/https://lemelson.mit.edu/winners/carolyn-bertozzi|url-status=dead}} The discovery led to her field of research, glycobiology. During Bertozzi's third year of graduate school, Bednarski was diagnosed with colon cancer, which resulted in him taking a leave of absence and changing his career path by enrolling in medical school. This left Bertozzi and the rest of the lab to complete their Ph.D. work with no direct supervision.{{Cite magazine |last=Azvolunsky |first=Anna |date=May 31, 2016 |title=Carolyn Bertozzi: Glycan Chemist |url=https://www.the-scientist.com/profile/carolyn-bertozzi-glycan-chemist-33453 |access-date=October 7, 2020 |magazine=The Scientist}}{{cite news |last1=Baker |first1=Mitzi |title=Bednarski, pioneer of new cancer therapies, dies at 47 |url=https://news.stanford.edu/news/2006/march22/med-obit-032206.html |access-date=15 October 2022 |work=Stanford University |date=22 March 2006 |language=en}}
Career and research
After graduating from Berkeley with a Ph.D., Bertozzi was a postdoctoral fellow at University of California, San Francisco (UCSF) with Steven Rosen, where she studied the activity of endothelial oligosaccharides in promoting cell adhesion at inflammation sites.{{cite journal |last1=Davis|first1=T.|title=Profile of Carolyn Bertozzi|journal=Proceedings of the National Academy of Sciences|date=February 16, 2010 |volume=107 |issue=7|pages=2737–2739|doi=10.1073/pnas.0914469107 |pmid=20160128|pmc=2840349|bibcode=2010PNAS..107.2737D|doi-access=free}}{{cite journal|last1=Gardiner|first1=Mary Beth|title=The Right Chemistry |journal=HHMI Bulletin|date=Winter 2005 |pages=8–12 |url=https://www.hhmi.org/sites/default/files/Bulletin/2005/Winter/winter2005_fulltext.pdf|accessdate=October 24, 2015}} While working with Rosen at UCSF, Bertozzi was able to modify the protein and sugar molecules in the walls of living cells so that the cells accept foreign materials such as implants.{{cite web|url=http://www.chemheritage.org/discover/online-resources/chemistry-in-history/themes/biomolecules/proteins-and-sugars/bertozzi.aspx |title=Carolyn Bertozzi|website=Chemical Heritage Foundation |url-status=dead |archive-date=July 12, 2016 |archive-url=https://web.archive.org/web/20160712164415/http://www.chemheritage.org/discover/online-resources/chemistry-in-history/themes/biomolecules/proteins-and-sugars/bertozzi.aspx}}
In 1996 Bertozzi became a faculty member in the UC Berkeley College of Chemistry{{cite news |last1=Sanders |first1=Robert |title=Chemistry Nobelist Carolyn Bertozzi's years at UC Berkeley |url=https://news.berkeley.edu/2022/10/05/chemistry-nobelist-carolyn-bertozzis-years-at-uc-berkeley/ |access-date=15 October 2022 |work=Berkeley News |date=5 October 2022}} and a faculty scientist at Lawrence Berkeley National Laboratory, where she served as the director of the Molecular Foundry.{{Cite web |url=https://newscenter.lbl.gov/2022/10/05/carolyn-bertozzi-wins-2022-nobel-chemistry| title= Former Berkeley Lab Scientist Carolyn Bertozzi Wins 2022 Nobel Prize in Chemistry| access-date=September 7, 2022 }} She has been an investigator with HHMI since 2000.{{cite web|title=Carolyn Bertozzi|url=http://www.hhmi.org/research/investigators/bertozzi_bio.html|publisher=HHMI|accessdate=February 8, 2013|archive-date=May 16, 2013|archive-url=https://web.archive.org/web/20130516204149/http://www.hhmi.org/research/investigators/bertozzi_bio.html|url-status=dead}} In 1999, while working with HHMI and at Berkeley, she founded the field of bioorthogonal chemistry and coined the term in 2003.{{Cite web|url=https://cen.acs.org/people/profiles/Carolyn-Bertozzis-glycorevolution/98/i5|title=Carolyn Bertozzi's glycorevolution|website=Chemical & Engineering News|language=en|access-date=February 12, 2020}}{{Cite web|url=https://www.invent.org/inductees/carolyn-bertozzi|title=NIHF Inductee Carolyn Bertozzi Invented Bioorthogonal Chemistry |website=www.invent.org |language=en|access-date=February 5, 2020}}{{Cite journal|last1=Sletten|first1=Ellen M.|last2=Bertozzi|first2=Carolyn R.|date=September 20, 2011|title=From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions |journal=Accounts of Chemical Research|volume=44|issue=9|pages=666–676|doi=10.1021/ar200148z|issn=0001-4842|pmc=3184615|pmid=21838330}} This new field and technique allows researchers to chemically modify molecules in living organisms and not interrupt the processes of the cell.{{Cite journal|last1=Sletten|first1=Ellen M.|last2=Bertozzi|first2=Carolyn R.|date=2009|title=Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality|journal=Angewandte Chemie International Edition in English|volume=48|issue=38|pages=6974–6998|doi=10.1002/anie.200900942|issn=1433-7851|pmc=2864149|pmid=19714693}} In 2015, Bertozzi moved to Stanford University to join the ChEM-H Institute.{{Cite web|url=https://bertozzigroup.stanford.edu/bio.htm|title=Carolyn R. Bertozzi|website=bertozzigroup.stanford.edu|access-date=April 13, 2018|archive-date=August 6, 2019|archive-url=https://web.archive.org/web/20190806163551/https://bertozzigroup.stanford.edu/bio.htm|url-status=dead}}
Bertozzi studies the glycobiology of underlying diseases such as cancer, inflammatory disorders such as arthritis, and infectious diseases such as tuberculosis. In particular, Bertozzi has advanced the understanding of cell surface oligosaccharides involved in cell recognition and inter-cellular communication. Bertozzi has applied the techniques of bioorthogonal chemistry to study glycocalyx, the sugars that surround the cell membrane. Her discoveries have advanced the field of biotherapeutics.{{Cite journal|last1=Xiao|first1=Han|last2=Woods|first2=Elliot C.|last3=Vukojicic|first3=Petar|last4=Bertozzi|first4=Carolyn R. |date=August 22, 2016|title=Precision glycocalyx editing as a strategy for cancer immunotherapy|journal=Proceedings of the National Academy of Sciences|language=en|volume=113|issue=37|pages=10304–10309|doi=10.1073/pnas.1608069113 |pmid=27551071|pmc=5027407|bibcode=2016PNAS..11310304X |issn=0027-8424|doi-access=free}} Her lab has also developed tools for research. One such development is creating chemical tools for studying glycans in living systems. Her lab's development of nanotechnologies which probe biological systems lead to the development of a fast point-of-care tuberculosis test in 2018.{{Cite journal |last1=Kamariza|first1=Mireille|last2=Shieh|first2=Peyton|last3=Ealand|first3=Christopher S.|last4=Peters|first4=Julian S.|last5=Chu|first5=Brian|last6=Rodriguez-Rivera|first6=Frances P.|last7=Babu Sait|first7=Mohammed R. |last8=Treuren|first8=William V.|last9=Martinson|first9=Neil|last10=Kalscheuer|first10=Rainer|last11=Kana|first11=Bavesh D.|date=2018|title=Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe|journal=Science Translational Medicine|volume=10|issue=430|pages=eaam6310 |doi=10.1126/scitranslmed.aam6310|issn=1946-6242|pmc=5985656|pmid=29491187}} In 2017, due to her lab's discovery of linking the sugars on the surface of cancer cells and their ability to avoid the immune system defenses, she was invited to speak at Stanford's TED talk, giving a talk entitled "What the sugar coating on your cells is trying to tell you".{{Cite web |url=https://www.ted.com/speakers/carolyn_bertozzi|title=Carolyn Bertozzi {{!}} Speaker {{!}} TED |last=Bertozzi|first=Carolyn|website=www.ted.com|language=en|access-date=February 5, 2020}}
=Biotechnology startups=
In 2001, Bertozzi and Steve Rosen co-founded Thios Pharmaceuticals in Emeryville, California, the first company to target sulfation pathways.{{Cite journal|last=McCarthy|first=Alice A.|date=February 2004|title=Thios Pharmaceuticals Targeting Sulfation Pathways|url=https://www.cell.com/cell-chemical-biology/pdf/S1074-5521(04)00040-7.pdf|journal=Chemistry & Biology|volume=11|issue=2|pages=147–148|doi=10.1016/j.chembiol.2004.02.008|pmid=15123271|doi-access=free}} Thios Pharmaceuticals dissolved in 2005.{{Cite web |title=Thios Pharmaceuticals {{!}} www.inknowvation.com |url=https://www.inknowvation.com/sbir/companies/thios-pharmaceuticals |access-date=2023-01-27 |website=www.inknowvation.com}}
In 2008, Bertozzi founded a startup of her own: Redwood Bioscience also in Emeryville, California.{{cite news|last1=McCook|first1=Alison|title=Women in Biotechnology: Barred from the Boardroom|url=http://www.scientificamerican.com/article/women-in-biotechnology-barred-from-the-boardroom/|accessdate=October 24, 2015|work=Scientific American|date=March 6, 2013}} Redwood Bioscience is a biotechnology company that uses [https://www.youtube.com/watch?v=1InC-VR1eNg SMARTag, a site-specific protein modification technology] that allows small drugs to attach to sites on the proteins and can be used to help fight cancers.{{Cite web|url=https://ipira.berkeley.edu/redwood-bioscience-inc|title=Redwood Bioscience Inc. {{!}} IPIRA|website=ipira.berkeley.edu|access-date=February 5, 2020}} Redwood Bioscience was acquired by [https://biologics.catalent.com/biologics/drug-substance/bioconjugate-development/precision-based-technology/ Catalent Pharma Solutions] in 2014. Bertozzi remains a part of the advisory board for the biologics sector of the company.
In 2014, she co-founded Enable Biosciences of South San Francisco, California.{{cite web |url=https://www.enablebiosciences.com/contact |title=Contact |publisher=Enable Biosciences |accessdate=October 13, 2022}} It focuses on biotechnologies for at-home diagnoses for type 1 diabetes, HIV, and other diseases.{{Cite web|url=https://ipira.berkeley.edu/enable-biosciences-inc|title=Enable Biosciences, Inc. {{!}} IPIRA|website=ipira.berkeley.edu|access-date=February 12, 2020}}
Bertozzi became a co-founder of Palleon Pharma of Waltham, Massachusetts, in 2015.{{Cite web|url=https://palleonpharma.com/leadership/|title=Palleon Pharma – Leadership|accessdate=October 5, 2022|archive-date=July 6, 2019|archive-url=https://web.archive.org/web/20190706121526/https://palleonpharma.com/leadership/|url-status=dead}} Palleon Pharma focuses on investigating glycoimmune checkpoint inhibitors as a potential treatment for cancer.{{Cite web|title=Palleon Pharma|url=https://www.massbio.org/members/palleon-pharma/|website=MassBio|language=en-US|access-date=May 28, 2020}}
In 2017, Bertozzi helped found InterVenn Biosciences, which uses mass spectrometry and artificial intelligence to enhance glycoproteomics for target and biomarker discovery, ovarian cancer diagnostics, and predicting the successes and failures of clinical trials.{{Cite web|url=http://intervenn.bio/|title=InterVenn Biosciences {{!}} AI-Driven Mass Spectrometry|website=intervenn.bio|access-date=February 12, 2020}}
She co-founded Grace Science Foundation in 2018. The foundation focuses on curing NGLY1 deficiency through developing therapeutics that are efficient and inexpensive.{{Cite web|url=https://rarediseases.info.nih.gov/organizations/3586|title=Grace Science Foundation|website=rarediseases.info.nih.gov|access-date=February 12, 2020|archive-date=October 22, 2020|archive-url=https://web.archive.org/web/20201022170634/https://rarediseases.info.nih.gov/organizations/3586|url-status=dead}}
In 2019, she co-founded both OliLux Biosciences and Lycia Therapeutics. OliLux Biosciences develops new methods for tuberculosis detection.{{Cite journal|last1=Dinkele|first1=Ryan|last2=Gessner|first2=Sophia|last3=Koch|first3=Anastasia S.|last4=Morrow|first4=Carl|last5=Gqada|first5=Melitta|last6=Kamariza|first6=Mireille|last7=Bertozzi|first7=Carolyn R.|last8=Smith|first8=Brian|last9=McLoud|first9=Courtney|last10=Kamholz|first10=Andrew|last11=Bryden|first11=Wayne|date=December 27, 2019|title=Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis bioaerosols|url=https://www.biorxiv.org/content/10.1101/2019.12.23.887729v1|journal=bioRxiv|language=en|pages=2019.12.23.887729|doi=10.1101/2019.12.23.887729|s2cid=213539003|doi-access=free}} The founding of Lycia Therapeutics occurred when Bertozzi's group discovered lysosome-targeting chimeras (LYTACs). The new molecule class may be able to degrade some cardiovascular disease and cancer targets.{{Cite journal|last1=Banik|first1=Steven|last2=Pedram|first2=Kayvon|last3=Wisnovsky|first3=Simon|last4=Riley|first4=Nicholas|last5=Bertozzi|first5=Carolyn|date=November 20, 2019|title=Lysosome Targeting Chimeras (LYTACs) for the Degradation of Secreted and Membrane Proteins|journal=Figshare|url=https://chemrxiv.org/articles/Lysosome_Targeting_Chimeras_LYTACs_for_the_Degradation_of_Secreted_and_Membrane_Proteins/7927061|language=en|doi=10.26434/chemrxiv.7927061.v2|s2cid=213002729 }} Lycia Therapeutics focuses on developing technology which utilizes lysosome-targeting chimeras (LYTACs).
Bertozzi also previously served on the research advisory board of several pharmaceutical companies including GlaxoSmithKline, and until 2021 Eli Lilly.{{Cite press release |title=Lilly Announces that Professor Carolyn Bertozzi has Resigned from its Board of Directors |url=https://www.prnewswire.com/news-releases/lilly-announces-that-professor-carolyn-bertozzi-has-resigned-from-its-board-of-directors-301362134.html |last=Lilly |first=Eli |access-date=October 12, 2024 |website=PR Newswire |language=en}} Bertozzi has served on the scientific advisory board of Colossal Biosciences since 2021.{{cite web|title=Dallas' Ben Lamm and Harvard's Dr. George Church Plan to 'De-Extinct' the Woolly Mammoth With Their Colossal New Startup|date=13 September 2021 |url=https://dallasinnovates.com/dallas-ben-lamm-and-harvards-dr-george-church-plan-to-de-extinct-the-woolly-mammoth-with-their-colossal-new-startup/}}
=Publications=
Bertozzi has over 600 publications on Web of Science; the most cited are:
- {{cite journal|pages=6974–98|doi=10.1002/anie.200900942|title=Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality|year=2009|last1=Sletten|first1=EM|journal=Angewandte Chemie International Edition in English|volume=48|issue=38|pmid=19714693|pmc=2864149|last2=Bertozzi|first2=CR}}
- {{cite journal |pages=2357–64 |doi=10.1126/science.1059820 |title=Chemical Glycobiology |year=2001 |last1=Bertozzi |first1=Carolyn R. |journal=Science |volume=291 |issue=5512 |pmid=11269316 |last2=Kiessling |first2=Laura L. |s2cid=9585674 |bibcode = 2001Sci...291.2357B }}
- {{cite journal |pages=2007–10 |doi=10.1126/science.287.5460.2007 |title=Cell Surface Engineering by a Modified Staudinger Reaction |year=2000 |last1=Saxon |first1=Eliana |journal=Science |volume=287 |issue=5460 |pmid=10720325 |last2=Bertozzi |first2=Carolyn R.|s2cid=19720277 |bibcode=2000Sci...287.2007S}}
- {{cite journal|pages=15046–15047|doi=10.1021/ja044996f|title=A Strain-Promoted [3 + 2] Azide−Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems|year=2005|last1=Agard |first1=Nicholas J. |last2=Prescher|first2=Jennifer A.|last3=Bertozzi|first3=Carolyn R.|journal=Journal of the American Chemical Society|volume=126|pmid=15547999|issue=46}}
- {{Cite journal|last1=Dube|first1=DH|last2=Bertozzi|first2=CR|title=Glycans in cancer and inflammation—potential for therapeutics and diagnostics|journal= Nature Reviews Drug Discovery|volume=4|issue=6|pages=477–88 |doi=10.1038/nrd1751|pmid=15931257|year=2005|s2cid=22525932}}
=Awards and honors=
File:Carolyn Bertozzi IMG 9372.jpg
- 1987 – Phi Beta Kappa{{Cite web|last=Chuang|first=Theodore D.|date=December 7, 1987|title=Harvard Phi Beta Kappa Inductees Announced {{!}} News {{!}} The Harvard Crimson|url=https://www.thecrimson.com/article/1987/12/7/harvard-phi-beta-kappa-inductees-announced/|url-status=live|access-date=June 1, 2021|website=www.thecrimson.com|archive-url=https://web.archive.org/web/20130910165402/http://www.thecrimson.com/article/1987/12/7/harvard-phi-beta-kappa-inductees-announced/ |archive-date=September 10, 2013 }}
- 1997 – Alfred P. Sloan Research Fellowship{{Cite web|date=November 4, 2002|title=Dr. Bertozzi to Speak at Drug Discovery Symposium|url=https://news.feinberg.northwestern.edu/2002/11/bertozzi_symposium/|access-date=June 1, 2021|website=News Center|language=en-US}}
- 1997 – Horace S. Isbell Award in Carbohydrate Chemistry{{Cite web|title=Horace S. Isbell Award|url=https://acscarb.org/awards/isbell-award/|access-date=June 1, 2021|website=ACS Carbohydrate|language=en-US}}
- 1998 – Glaxo Wellcome Scholars' Award
- 1998 – Beckman Young Investigators Award{{cite web |title=Carolyn R. Bertozzi |url=http://www.beckman-foundation.org/beckman-young-investigators/carolyn-r-bertozzi |website=Arnold and Mabel Beckman Foundation |accessdate=August 1, 2018 |archive-date=August 2, 2018 |archive-url=https://web.archive.org/web/20180802041126/http://www.beckman-foundation.org/beckman-young-investigators/carolyn-r-bertozzi |url-status=dead }}
- 1999 – Arthur C. Cope Scholar Award of the American Chemical Society{{Cite web|title=Arthur C. Cope Scholar Awards|url=https://www.acs.org/content/acs/en/funding-and-awards/awards/national/bytopic/arthur-cope-scholar-award.html|access-date=June 1, 2021|website=American Chemical Society|language=en}}
- 1999 – Camille Dreyfus Teacher-Scholar Award
- 1999 – MacArthur Fellowship{{Cite web|title=Major Awards & Honors {{!}} College of Chemistry|url=https://chemistry.berkeley.edu/awards-honors|access-date=June 1, 2021|website=chemistry.berkeley.edu}}
- 2000 – Presidential Early Career Award for Scientists and Engineers{{Cite web|url=https://clintonwhitehouse4.archives.gov/WH/EOP/OSTP/html/00413_2.html|title=President Honors Outstanding Young Scientists|website=clintonwhitehouse4.archives.gov|access-date=September 7, 2019}}
- 2000 – Merck Academic Development Program Award
- 2001 – UC Berkeley Distinguished Teaching Award
- 2001 – ACS Award in Pure Chemistry
- 2001 – Donald Sterling Noyce Prize for Excellence in Undergraduate Teaching
- 2001 – Fellow of the American Association for the Advancement of Science{{cite news |last1=Korte |first1=Andrea |title=AAAS Fellows Carolyn Bertozzi and K. Barry Sharpless Receive Nobel Prize in Chemistry {{!}} American Association for the Advancement of Science |url=https://www.aaas.org/news/aaas-fellows-carolyn-bertozzi-and-k-barry-sharpless-receive-nobel-prize-chemistry?et_rid=162180701&et_cid=4466269 |access-date=29 October 2022 |work=American Association for the Advancement of Science |date=5 October 2022 |language=en}}
- 2002 – Irving Sigal Young Investigator Award of the Protein Society{{Cite web|title=UC Berkeley chemist, biologist, entrepreneur awarded $500,000 Lemelson–MIT Prize {{!}} Research UC Berkeley|url=https://vcresearch.berkeley.edu/news/uc-berkeley-chemist-biologist-entrepreneur-awarded-500000-lemelson-mit-prize|access-date=June 1, 2021|website=vcresearch.berkeley.edu}}
- 2003 – Fellow of the American Academy of Arts and Sciences{{cite web|title=Book of Members, 1780–2010: Chapter B|url=http://www.amacad.org/publications/BookofMembers/ChapterB.pdf|publisher=American Academy of Arts and Sciences|accessdate=June 24, 2011}}
- 2003 – Havinga Medal, Univ. Leiden{{Cite web |title=Laureates |url=https://www.universiteitleiden.nl/en/havinga-foundation/laureates |access-date=2024-03-12 |website=www.universiteitleiden.nl |language=en}}
- 2004 – Agnes Fay Morgan Research Award of Iota Sigma Pi{{Cite web |title=2004 IOTA SIGMA PI AGNES FAY MORGAN RESEARCH AWARD |url=http://www.iotasigmapi.info/awards/agnesfaymorgan/2004.pdf |url-status=dead |archive-url=https://web.archive.org/web/20190501165437/http://www.iotasigmapi.info/awards/agnesfaymorgan/2004.pdf |archive-date=2019-05-01 |access-date= |website=Iota Sigma Pi}}
- 2005 – Member of the National Academy of Sciences
- 2005 – T.Z. and Irmgard Chu Distinguished Professorship in Chemistry{{Cite web|url=https://www.berkeley.edu/news/media/releases/2005/05/03_nas.shtml|title=05.03.2005 – Three UC Berkeley faculty named to National Academy of Sciences|website=www.berkeley.edu|access-date=September 7, 2019}}
- 2007 – Ernst Schering Prize{{Cite web|title=Ernst Schering Prize 2007 – Schering Stiftung|url=https://scheringstiftung.de/en/programm/lebenswissenschaften/ernst-schering-preis/ernst-schering-preis-2007/|access-date=June 1, 2021|language=en-US}}
- 2007 – LGBTQ Scientist of the Year Award – from the National Organization of Gay and Lesbian Scientists and Technical Professionals
- 2008 – Li Ka Shing Women in Science Award
- 2008 – Roy L. Whistler International Award in Carbohydrate Chemistry{{Cite journal|last=Kamerling|first=Johannis P.|date=March 1, 2008|title=The Roy L. Whistler International Award in Carbohydrate Chemistry 2008|url=https://academic.oup.com/glycob/article/18/3/209/1988289|journal=Glycobiology|language=en|volume=18|issue=3|pages=209|doi=10.1093/glycob/cwn005|pmid=18326004|issn=0959-6658|doi-access=free}}
- 2008 – Member of the German Academy of Sciences Leopoldina{{cite web|url=http://www.leopoldina.org/en/members/list-of-members/member/1308/|title=List of Members|website=www.leopoldina.org|accessdate=October 8, 2017}}
- 2008 – Willard Gibbs Award{{Cite web|url=https://archive.chicagoacs.net/meetings/08may.html|title=ACS May Gibbs Award Meeting|website=archive.chicagoacs.net|accessdate=October 5, 2022}}
- 2009 – William H. Nichols Medal{{Cite web|title=Nichols Medal|url=http://newyorkacs.online/nichols_medal/|access-date=June 1, 2021|website=newyorkacs.online|language=en}}
- 2009 – Harrison Howe Award{{Cite web|url=https://cen.acs.org/articles/87/i8/Carolyn-Bertozzi-Wins-Harrison-Howe.html?type=paidArticleContent|title=Carolyn Bertozzi Wins Harrison Howe Award {{!}} February 23, 2009, Issue – Vol. 87 Issue 8 {{!}} Chemical & Engineering News|website=cen.acs.org|access-date=September 7, 2019}}
- 2009 – Albert Hofmann Medal, Univ. Zurich{{Cite web |title=Carolyn R. Bertozzi awarded Nobel Prize in Chemistry |url=https://www.leopoldina.org/en/press-1/news/carolyn-r-bertozzi-awarded-nobel-prize-in-chemistry/ |access-date=2024-03-12 |website=Nationale Akademie der Wissenschaften Leopoldina |language=en-US}}
- 2010 – Lemelson–MIT Prize{{cite web|title=Carolyn Bertozzi 2010 Lemelson–MIT Prize|url=http://lemelson.mit.edu/winners/carolyn-bertozzi|publisher=MIT|accessdate=May 13, 2014|archive-date=August 10, 2020|archive-url=https://web.archive.org/web/20200810095535/https://lemelson.mit.edu/winners/carolyn-bertozzi|url-status=dead}}
- 2010 – Royal Society of Chemistry – Organic Division, Bioorganic Chemistry Award
- 2011 – Member of the Institute of Medicine{{Cite web|url=https://news.berkeley.edu/2011/10/17/two-uc-berkeley-faculty-elected-to-iom/|title=Two UC Berkeley faculty named to Institute of Medicine|website=Berkeley News|language=en-US|access-date=February 10, 2020|date=November 30, 2001}}
- 2011 – Tetrahedron Young Investigator Award for Bioorganic and Medicinal Chemistry{{Cite web|url=https://www.sciencedirect.com/journal/bioorganic-and-medicinal-chemistry-letters/vol/21/issue/17|title=Bioorganic & Medicinal Chemistry Letters {{!}} Tetrahedron Young Investigator Award 2011: Carolyn R. Bertozzi {{!}} ScienceDirect.com|website=www.sciencedirect.com|language=en-us|access-date=September 7, 2019}}
- 2011 – Emanuel Merck Lectureship{{Cite web|title=EM Lectureship – Research {{!}} Merck KGaA, Darmstadt, Germany|url=https://www.emdgroup.com/en/research/grants-and-awards/emanuel-merck-lectureship.html|access-date=June 1, 2021|website=www.emdgroup.com|language=en}}
- 2012 – Honorary Doctorate of Science from Brown University{{cite web|title=Simmons among nine honorary degree recipients|url=http://news.brown.edu/pressreleases/2012/05/hdcitations#Bertozzi|publisher=Brown University|accessdate=May 28, 2014|date=May 16, 2012}}
- 2012 – Heinrich Wieland Prize{{cite web|title=Heinrich Wieland Prize 2012 goes to Carolyn R. Bertozzi |url=http://www.heinrich-wieland-preis.de/index/getnews/id/15 |archive-url=https://archive.today/20140702042822/http://www.heinrich-wieland-preis.de/index/getnews/id/15 |url-status=dead |archive-date=July 2, 2014 |publisher=Boehringer Ingelheim Foundation |accessdate=June 30, 2014 |date=October 18, 2012 }}
- 2013 – Elected Fellow of the National Academy of Inventors{{Cite web|url=https://vcresearch.berkeley.edu/news/carolyn-bertozzi-and-george-smoot-elected-national-academy-inventors|title=Carolyn Bertozzi and George Smoot Elected to National Academy of Inventors {{!}} Research UC Berkeley|website=vcresearch.berkeley.edu|access-date=September 7, 2019}}
- 2013 – Hans Bloemendal Award{{Cite web|url=http://www2.rimls.nl/symposia/frontiers-2013/bloemendal-medal/|title=Bloemendal Medal|website=www2.rimls.nl|access-date=September 7, 2019|archive-date=June 16, 2021|archive-url=https://web.archive.org/web/20210616043303/http://www2.rimls.nl/symposia/frontiers-2013/bloemendal-medal/|url-status=dead}}
- 2015 – UCSF 150th Anniversary Alumni Excellence Awards{{Cite web|url=https://bertozzigroup.stanford.edu/carolyn-bertozzi|title=Carolyn Bertozzi|website=Bertozzi Group|accessdate=October 5, 2022}}
- 2017 – Arthur C. Cope Award{{cite web|title=Arthur C. Cope Awards|date=August 25, 2016 |url=https://www.organicdivision.org/cope}}
- 2018 – Foreign Member of the Royal Society (ForMemRS){{cite web|url=https://royalsociety.org/news/2018/05/distinguished-scientists-elected-fellows-royal-society-2018/|title=Distinguished scientists elected as Fellows and Foreign Members of the Royal Society |publisher=The Royal Society|date=May 9, 2018|accessdate=May 10, 2018 }}
- 2020 – John J. Carty Award for the Advancement of Science{{Cite web|url=http://www.nasonline.org/programs/awards/2020-awards/Bertozzi.html|title=Carolyn Bertozzi|website=www.nasonline.org|access-date=January 22, 2020}}
- 2020 – Chemistry for the Future Solvay Prize{{Cite web|url=https://www.solvay.com/en/innovation/encourage-science/chemistry-future-solvay-prize/2020-laureate|title=Chemistry for the Future Solvay Prize – The 2020 Laureate|website=Solvay|language=en|access-date=February 5, 2020}}
- 2020 – F. A. Cotton Medal for Excellence in Chemical Research{{Cite web|url=https://www.chem.tamu.edu/medals+lectureships/cotton-medal/|title=F.A. Cotton Medal|website=chem.tamu.edu|access-date=June 9, 2020}}
- 2022 – Wolf Prize in Chemistry{{Cite web|url=https://wolffund.org.il/2022/02/08/carolyn-r-bertozzi/|title=Carolyn R. Bertozzi|date=February 8, 2022|accessdate=October 5, 2022|archive-date=March 13, 2022|archive-url=https://web.archive.org/web/20220313054324/https://wolffund.org.il/2022/02/08/carolyn-r-bertozzi/|url-status=dead}}
- 2022 – Dr H. P. Heineken Prize for Biochemistry and Biophysics{{cite web|url=https://www.theheinekencompany.com/newsroom/winners-of-heineken-prizes-2022-announced/|title=Winners of Heineken Prizes 2022 announced|publisher=Heineken|date=June 8, 2022|accessdate=October 3, 2022}}
- 2022 – Dickson Prize in Medicine[http://www.dicksonprize.pitt.edu/recipients/2022-bertozzi.php Dickson Prize 2022]
- 2022 – Welch Award in Chemistry{{Cite web|url=https://welch1.org/awards/welch-award-in-chemistry|title=Welch Award in Chemistry|website=Welch|accessdate=October 5, 2022}}
- 2022 – Bijvoet Medal of the Bijvoet Centre for Biomolecular Research of Utrecht University{{cite web|url=https://www.uu.nl/en/news/bijvoet-medals-awarded-to-carolyn-bertozzi-and-vishva-dixit|title=Bijvoet Medals awarded to Carolyn Bertozzi and Vishva Dixit|publisher=Utrecht University|date=October 3, 2022|accessdate=October 3, 2022}}
- 2022 – Lifetime Mentor Award, American Association for the Advancement of Science.{{cite news |last1=Jilani |first1=Zaid |title=Carolyn R. Bertozzi Wins 2022 AAAS Lifetime Mentor Award {{!}} American Association for the Advancement of Science |url=https://www.aaas.org/news/carolyn-r-bertozzi-wins-2022-aaas-lifetime-mentor-award?adobe_mc=MCMID%3D83613660772200808932157120907812278803%7CMCORGID%3D242B6472541199F70A4C98A6%2540AdobeOrg%7CTS%3D1667060068 |access-date=29 October 2022 |work=American Association for the Advancement of Science |date=10 February 2022 |language=en}}
- 2022 – Nobel Prize in Chemistry
- 2023 – Roger Adams Award{{Cite web|url=https://www.organicdivision.org/adamsaward/|title=Roger Adams Award|website=www.organicdivision.org|accessdate=February 28, 2023}}
- 2023 – AACR Award for Outstanding Achievement in Chemistry in Cancer Research{{Cite web |title=Nobel Laureate Carolyn R. Bertozzi, PhD, to Receive 2023 AACR Award for Outstanding Achievement in Chemistry in Cancer Research |url=https://www.aacr.org/about-the-aacr/newsroom/news-releases/nobel-laureate-carolyn-r-bertozzi-phd-to-receive-2023-aacr-award-for-outstanding-achievement-in-chemistry-in-cancer-research/ |access-date=2024-01-06 |website=American Association for Cancer Research (AACR) |language=en}}
- 2024 – Priestley Medal, American Chemical Society{{Cite web |title=Carolyn Bertozzi named 2024 Priestley medalist |url=https://cen.acs.org/people/awards/Carolyn-Bertozzi-named-2024-Priestley-medalist/101/web/2023/06 |access-date=2024-08-28 |website=Chemical & Engineering News |language=en}}
Personal life
Bertozzi grew up in Lexington, Massachusetts, the daughter of the late Norma Gloria (Berringer) and William Bertozzi.{{cite web | url=https://www.legacy.com/us/obituaries/bostonglobe/name/norma-bertozzi-obituary?id=30733422 | title=NORMA GLORIA BERTOZZI Obituary (2021) Boston Globe | website=Legacy.com }} Her father was of Italian descent.{{Cite web|url=https://lavocedinewyork.com/en/news/2022/10/05/italian-american-scientist-carolyn-bertozzi-wins-the-nobel-prize-in-chemistry|title=Italian American Scientist Carolyn Bertozzi Wins the Nobel Prize in Chemistry|date=October 5, 2022 }}{{cite web|title=Il Nobel per la chimica 2022 a Bertozzi, Meldal e Sharpless |url=https://www.rainews.it/tgr/piemonte/articoli/2022/10/attesa-per-lassegnazione-del-nobel-per-la-chimica-2022-7e183214-ce64-4cf4-b5b4-a1fac3bccbd8.html}} Her maternal grandparents were from Nova Scotia, Canada.{{cite web | url=https://digital.sciencehistory.org/works/3xomins | title=Oral history interview with Carolyn R. Bertozzi }} She has two sisters, one of whom, Andrea Bertozzi, is on the mathematics faculty at the University of California, Los Angeles.{{cite web|url=https://www.math.ucla.edu/~bertozzi/|title=UCLA Math Department Faculty|accessdate=June 4, 2012}} Her father was a physics professor at the Massachusetts Institute of Technology.{{cite web|url=http://web.mit.edu/physics/people/faculty/bertozzi_william.html|title=MIT Physics Department Faculty|accessdate=June 4, 2012}}
Bertozzi and her two sisters grew up around science. Because their father was a physics professor, when asked what she and her sisters wanted to be when they grew up, the answer was unanimous: a nuclear physicist. The three girls would attend MIT camps, as their father dreamt that they would attend MIT due to a "mixture of pride and the promise of free tuition". To William's dismay, Carolyn attended Harvard instead because the school offered strengths outside of just science.
Bertozzi briefly considered a career in music. In high school, she won several awards for music compositions and musical accomplishments. Her talent on the keyboard earned her offers as a music major from several university rock bands, but she felt that she was "always centered on the sciences". Bertozzi is a lesbian and has been out since the late 1980s.{{Cite journal|last=Navals|first=Pauline|date=April 5, 2022|title=ONE ON ONE WITH CAROLYN BERTOZZI|journal=Chemical & Engineering News|language=en|url=https://cen.acs.org/biological-chemistry/One-on-one-with-Carolyn-Bertozzi/100/i12}}
References
External links
{{Scholia}}
- {{official website|https://bertozzigroup.stanford.edu/}} of Bertozzi Research Group
- [https://www.ted.com/talks/carolyn_bertozzi_what_the_sugar_coating_on_your_cells_is_trying_to_tell_you/up-next What the sugar coating on your cells is trying to tell you] – TED Talk
{{Commons category|Carolyn Bertozzi}}
- {{nobelprize}}
- [https://oa.mg/author/A2248816173 Bertozzi's] et al. publication list
- {{Cite journal |vauthors=Hardcastle M |title=QnAs with Carolyn R. Bertozzi |journal=Proceedings of the National Academy of Sciences of the United States of America |year=2023 |volume=120 |issue=1 |pages=e2220665120|doi=10.1073/pnas.2220665120 |doi-access=free |pmid=36584297 |pmc=9910447 |bibcode=2023PNAS..12020665H }}
{{ACS Chemical Biology Lectureship}}
{{FRS 2018}}
{{Nobel Prize in Chemistry Laureates 2001–2025}}
{{2022 Nobel Prize winners}}
{{Authority control}}
{{DEFAULTSORT:Bertozzi, Carolyn}}
Category:21st-century American women
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Category:American people of Italian descent
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Category:Members of the German National Academy of Sciences Leopoldina
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Category:Nobel laureates in Chemistry
Category:Recipients of the Presidential Early Career Award for Scientists and Engineers
Category:Stanford University Department of Chemistry faculty
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Category:UC Berkeley College of Chemistry faculty
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