Castelsantangelo sul Nera

{{Infobox Italian comune

| name = Castelsantangelo sul Nera

| official_name = Comune di Castelsantangelo sul Nera

| native_name =

| image_skyline = Castelsantangelo sul Nera 2009.jpg

| imagesize =

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| image_caption =

| image_shield = Castelsantangelo sul Nera-Stemma.png

| shield_alt =

| image_map =

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| coordinates = {{coord|42|54|N|13|9|E|type:city(357)_region:IT|display=inline}}

| coordinates_footnotes =

| region = Marche

| province = Macerata (MC)

| frazioni = Gualdo, Macchie, Nocelleto, Nocria, Pian dell'Arco, Rapegna, Spina di Gualdo, Vallinfante

| mayor_party =

| mayor = Mauro Falcucci

| area_footnotes =

| area_total_km2 = 71.2

| population_footnotes = All demographics and other statistics: Italian statistical institute Istat.

| population_total = 281

| population_as_of = 31 December 2015

| pop_density_footnotes =

| population_demonym = Castellani

| elevation_footnotes =

| elevation_m = 760

| twin1 =

| twin1_country =

| saint = St. Stephen

| day = 26 December

| postal_code = 62030

| area_code = 0737

| website =

| footnotes =

}}

Castelsantangelo sul Nera is a comune (municipality) in the Province of Macerata in the Italian region of Marche, located about {{convert|90|km|mi}} southwest of Ancona and about {{convert|50|km|mi}} southwest of Macerata. The source of the Nera River is located in the communal territory.