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CatSper1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

CatSper1, is a protein which in humans is encoded by the CATSPER1 gene.{{cite journal | vauthors = Quill TA, Ren D, Clapham DE, Garbers DL | title = A voltage-gated ion channel expressed specifically in spermatozoa | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 22 | pages = 12527–31 |date=October 2001 | pmid = 11675491 | pmc = 60087 | doi = 10.1073/pnas.221454998 | bibcode = 2001PNAS...9812527Q | doi-access = free }}{{cite journal | vauthors = Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE | title = A sperm ion channel required for sperm motility and male fertility | journal = Nature | volume = 413 | issue = 6856 | pages = 603–9 |date=October 2001 | pmid = 11595941 | doi = 10.1038/35098027 | bibcode = 2001Natur.413..603R | s2cid = 4424815 | pmc = 8462998 }}{{cite journal | vauthors = Clapham DE, Garbers DL | title = International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels | journal = Pharmacol. Rev. | volume = 57 | issue = 4 | pages = 451–4 |date=December 2005 | pmid = 16382101 | doi = 10.1124/pr.57.4.7 | s2cid = 35096827 }} CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.{{cite web | url = http://www.iuphar-db.org/IC/FamilyIntroductionForward?familyId=13 | title = CatSper and Two-Pore Channels: Introduction | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-16 | archive-date = 2012-09-05 | archive-url = https://web.archive.org/web/20120905080216/http://www.iuphar-db.org/IC/FamilyIntroductionForward?familyId=13 | url-status = dead }}

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.{{cite web | title = Entrez Gene: CatSper1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117144 }}

References

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Further reading

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  • {{cite journal |vauthors=Li HG, Liao AH, Ding XF |title=The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa |journal=Asian J. Androl. |volume=8 |issue= 3 |pages= 301–6 |year= 2006 |pmid= 16625279 |doi= 10.1111/j.1745-7262.2006.00132.x |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
  • {{cite journal |vauthors=Zhang D, Chen J, Saraf A |title=Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity |journal=J. Biol. Chem. |volume=281 |issue= 31 |pages= 22332–41 |year= 2006 |pmid= 16740636 |doi= 10.1074/jbc.M511288200 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Avenarius MR, Hildebrand MS, Zhang Y |title=Human Male Infertility Caused by Mutations in the CATSPER1 Channel Protein |journal=Am. J. Hum. Genet. |volume=84 |issue= 4 |pages= 505–10 |year= 2009 |pmid= 19344877 |doi= 10.1016/j.ajhg.2009.03.004 |pmc=2667975 |display-authors=etal}}
  • {{cite journal |author=Garbers DL |title=Ion channels. Swimming with sperm |journal=Nature |volume=413 |issue= 6856 |pages= 579, 581–2 |year= 2001 |pmid= 11595929 |doi= 10.1038/35098164 |bibcode=2001Natur.413..579G |s2cid=6099942 }}
  • {{cite journal |vauthors=Quill TA, Ren D, Clapham DE, Garbers DL |title=A voltage-gated ion channel expressed specifically in spermatozoa |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 22 |pages= 12527–31 |year= 2001 |pmid= 11675491 |doi= 10.1073/pnas.221454998 |pmc=60087 |bibcode=2001PNAS...9812527Q |doi-access=free }}
  • {{cite journal |vauthors=Clapham DE, Garbers DL |title=International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 451–4 |year= 2005 |pmid= 16382101 |doi= 10.1124/pr.57.4.7 |s2cid=35096827 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Nikpoor P, Mowla SJ, Movahedin M |title=CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility |journal=Hum. Reprod. |volume=19 |issue= 1 |pages= 124–8 |year= 2004 |pmid= 14688170 |doi=10.1093/humrep/deh043 |display-authors=etal|doi-access= }}
  • {{cite journal |vauthors=Ren D, Navarro B, Perez G |title=A sperm ion channel required for sperm motility and male fertility |journal=Nature |volume=413 |issue= 6856 |pages= 603–9 |year= 2001 |pmid= 11595941 |doi= 10.1038/35098027 |bibcode=2001Natur.413..603R |s2cid=4424815 |display-authors=etal|pmc=8462998 }}

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{{NLM content}}

{{Ion channels|g1}}

Category:Ion channels

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