Login
Login

Cathepsin W

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{cs1 config|name-list-style=vanc}}{{Infobox_gene}}

Cathepsin W is a protein that in humans is encoded by the CTSW gene.{{cite journal | vauthors = Linnevers C, Smeekens SP, Brömme D | title = Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes | journal = FEBS Lett | volume = 405 | issue = 3 | pages = 253–9 |date=May 1997 | pmid = 9108299 | doi = 10.1016/S0014-5793(97)00118-X| s2cid = 45420314 | doi-access = | bibcode = 1997FEBSL.405..253L }}{{cite journal | vauthors = Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D | title = Genomic structure, chromosomal localization, and expression of human cathepsin W | journal = Biochem Biophys Res Commun | volume = 248 | issue = 2 | pages = 255–61 |date=Aug 1998 | pmid = 9675123 | doi = 10.1006/bbrc.1998.8954 }}{{cite web | title = Entrez Gene: CTSW cathepsin W| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1521}}

The protein encoded by this gene, a member of the peptidase C1 family of cysteine cathepsins, is a cysteine protease cathepsin that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the cell membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
  • {{cite journal | vauthors=Meinhardt C, Peitz U, Treiber G |title=Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 4 |pages= 975–80 |year= 2004 |pmid= 15358123 |doi= 10.1016/j.bbrc.2004.07.056 |display-authors=etal}}
  • {{cite journal | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 |pmc=2286551}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Buhling F, Kellner U, Guenther D |title=Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract. |journal=Biol. Chem. |volume=383 |issue= 7–8 |pages= 1285–9 |year= 2003 |pmid= 12437118 |doi=10.1515/BC.2002.144 |s2cid=23389714 |display-authors=etal}}
  • {{cite journal | vauthors=Wex T, Bühling F, Wex H |title=Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum. |journal=J. Immunol. |volume=167 |issue= 4 |pages= 2172–8 |year= 2001 |pmid= 11490002 |doi= 10.4049/jimmunol.167.4.2172|display-authors=etal|doi-access=free }}
  • {{cite book | vauthors=Wex T, Levy B, Wex H, Brömme D |chapter=Human Cathepsins W and F form a New Subgroup of Cathepsins that is Evolutionary Separated from the Cathepsin B- and L-Like Cysteine Proteases |title=Cellular Peptidases in Immune Functions and Diseases 2 |series=Advances in Experimental Medicine and Biology |volume=477 |pages= 271–80 |year= 2000 |pmid= 10849754 |doi=10.1007/0-306-46826-3_29 |isbn=0-306-46383-0 }}
  • {{cite journal | vauthors=Brinkworth RI, Tort JF, Brindley PJ, Dalton JP |title=Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes. |journal=Int. J. Biochem. Cell Biol. |volume=32 |issue= 3 |pages= 373–84 |year= 2000 |pmid= 10716634 |doi=10.1016/S1357-2725(99)00129-6 }}
  • {{cite journal | vauthors=Wex T, Levy B, Wex H, Brömme D |title=Human cathepsins F and W: A new subgroup of cathepsins. |journal=Biochem. Biophys. Res. Commun. |volume=259 |issue= 2 |pages= 401–7 |year= 1999 |pmid= 10362521 |doi= 10.1006/bbrc.1999.0700 }}
  • {{cite journal | vauthors=Brown J, Matutes E, Singleton A |title=Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. |journal=Leukemia |volume=12 |issue= 11 |pages= 1771–81 |year= 1998 |pmid= 9823953 |doi=10.1038/sj.leu.2401164 |display-authors=etal|doi-access= |s2cid=31373986 }}

{{refend}}

External links

  • The MEROPS online database for peptidases and their inhibitors: [https://archive.today/20121223061005/http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=C01.037 C01.037]

{{Cysteine proteases}}

{{Enzymes}}

{{Portal bar|Biology|border=no}}

Category:Proteases

Category:EC 3.4.22

Category:Cathepsins

{{gene-11-stub}}